Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease

Chen, Liling; Huang, Zhidong; Li, Weiguo; He, Yibo; Liang, Jingjing; Lu, Jin Song; Yang, Yanfang; Huang, Haozhang; Lin, Yihang; Lin, Rongwen; Lin, Min; Hu, Yunzhao; Ye, Jianfeng; Hu, Yuying; Liu, Jin; Liu, Yong; Yong, Fang; Chen, Kaihong; Chen, Shiqun

doi:10.1007/s11255-021-02915-6

Cited by 5 publications

(8 citation statements)

References 22 publications

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“…The characteristics of the included studies are summarized in Table 1 . A total of 273,315 individuals were included in three cross-sectional studies [ 12 , 15 , 16 ], five prospective cohort studies [ 17 – 21 ], and nine retrospective cohort studies [ 10 , 11 , 22 – 28 ]. The population of the original studies was mainly from China [ 10 – 12 , 17 – 21 , 23 , 25 , 28 ]; three were from Turkey [ 16 , 22 , 24 , 26 , 27 ], and one was from America [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis

Xiang,

Zhu,

Zhang

2023

International Journal of Clinical Practice

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Background. Acute kidney injury (AKI) is a complex clinical syndrome of hospitalization that may be affected by undernutrition and metabolic changes. The aim of this meta-analysis was to systematically assess the association between malnutrition and the risk of prevalent AKI. Materials and Methods. We searched PubMed, Embase, Ovid MEDLINE, Web of Science, and Chinese databases (WANFANG, VIP, and CKI) from database inception until May 1, 2023, for studies evaluating the association of malnutrition with the risk of AKI. Summary odds ratios (ORs) were estimated using a random-effects model. Results. We identified 17 observational studies, which included 273,315 individuals. Compared with patients with normal nutritional status, those with malnutrition had a 125% increased risk of prevalent AKI (pooled ORs, 2.25; 95% confidence interval, 1.80–2.82). Malnutrition was also significantly associated with prevalent AKI across all subgroups when subgroup analyses were performed on covariates such as region, study design, age, sample size, malnutrition assessment method, patient characteristics, covariate adjustment degree, and risk of bias. Meta-regression models demonstrated no significant differences in AKI risk between patients with malnutrition and without malnutrition. Conclusions. Our results suggest that malnutrition may be a potential target for AKI prevention. However, well-designed studies with ethnically or geographically diverse populations are needed to evaluate strategies and interventions to prevent or slow the development and progression of AKI in malnourished individuals.

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Section: Resultsmentioning

confidence: 99%

Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis

Xiang,

Zhu,

Zhang

2023

International Journal of Clinical Practice

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“…Additionally, recent studies have suggested that malnutrition, like inflammation, may play an important role in the development of CIN [16,17]. Chen and colleagues showed that malnutrition is associated with a twofold increased risk of CIN in patients with chronic artery disease undergoing coronary angiography [17]. Therefore, we thought that PNI, which contains information about both inflammation and nutritional status, may be useful in predicting CIN.…”

Section: Discussionmentioning

confidence: 97%

“…Also, Yuan et al evaluated the predictive value of relevant inflammatory factors on CIN development including; white blood cell count, NLR, CRP level, hs-CRP level, and endothelin-1 level on CIN development, in patients undergoing an emergency PCI and the results had shown that inflammatory factors were all associated with an increased risk of CIN development in patient group [14]. Additionally, recent studies have suggested that malnutrition, like inflammation, may play an important role in the development of CIN [16,17]. Chen and colleagues showed that malnutrition is associated with a twofold increased risk of CIN in patients with chronic artery disease undergoing coronary angiography [17].…”

Section: Discussionmentioning

confidence: 99%

The predictive value of the prognostic nutritional index for contrast-induced nephropathy

et al. 2022

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This study aims to evaluate the association between prognostic nutritional index (PNI) and contrast-induced nephropathy (CIN).Material and methods: A total of 251 patients who were at high risk for contrast nephropathy were included in the study. The patients were grouped according to their PNI score (PNI score <45 or PNI score ≥45). CIN was defined as a 25% relative increase, or 0.5 mg/dL absolute increase in serum creatinine level above baseline within 72 hours of contrast exposure, in the absence of an alternative explanation.Results: Two groups were assigned according to the PNI score. The first group consists of 111 patients (PNI<45) and the second group has 140 patients (PNI≥45). CIN developed in 162 (%64.8) patients. C-reactive protein was higher in the low-PNI group. Also, the patients with the low-PNI group had lower ejection fraction, lower serum albumin levels, and lower hemoglobin levels. CIN, postprocedure renal replacement therapy requirement and in-hospital mortality were higher in the low PNI group. Multivariable logistic regression analysis revealed that advanced age (p=0.012, [OR] = 1.044 [1.009-1.079]), low baseline GFR (p=0.033, [OR]= 1.022 [1.002-1.043]), high amount of contrast media (p=0.022, [OR]= 1.017 [1.002-1.031]), and low PNI score (p=0.033 , [OR]= 2.069 [1.060-4.039]) were independent predictors of CIN.Conclusion: Our study demonstrated that the PNI score was an independent risk factor for the development of CIN.

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Section: Discussionmentioning

confidence: 99%

“…13 In CAD patients undergoing PCI, malnutrition defined by the CONUT score was associated with higher risk of contrast-associated acute kidney injury even after adjustment for confounders. [26][27][28] Several scoring systems, such as the geriatric nutritional risk index (GNRI), CONUT score, nutritional risk index (NRI), and prognostic nutritional index (PNI), have been developed to estimate nutritional status. 29 Currently, there is no consensus regarding which scoring systems has the best predictive value in CAD patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Controlling Nutritional Status Score With Adverse Outcomes in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

Huang

Sun

et al. 2022

Angiology

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This systematic review and meta-analysis sought to examine the association between the controlling nutritional status (CONUT) score and adverse outcomes in patients with coronary artery disease (CAD). PubMed and Embase databases were searched for eligible studies from their inceptions to December 12, 2021 to identify studies investigating the association of the CONUT score with major adverse cardiovascular events (MACEs) and all-cause mortality in CAD patients. Twelve studies (36,198 CAD) patients satisfied the criteria. Comparison of the high with low CONUT score, the pooled multivariate adjusted risk ratios (RR) was 1.78 (95% confidence intervals [CI] 1.36-2.32) for MACEs and 1.45 (95% CI 1.27–1.66) for all-cause mortality, respectively. When compared with patients with normal nutrition, malnourished (defined by the CONUT score ≥2) patients conferred a 52% increased risk of MACEs. Additionally, per point CONUT score increment was associated with 15% and 11% higher risk of MACEs and all-cause mortality, respectively. Higher CONUT score independently predicts the MACEs all-cause mortality in CAD patients. Estimation of nutritional status using the CONUT score could be helpful for improving risk classification of CAD.

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Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease

Cited by 5 publications

References 22 publications

Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis

Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis

The predictive value of the prognostic nutritional index for contrast-induced nephropathy

Association of Controlling Nutritional Status Score With Adverse Outcomes in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis

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