volume 191, issue 12, P6200-6207 2013
DOI: 10.4049/jimmunol.1300744
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Michal Marzec, Krzysztof Halasa, Xiaobin Liu, Hong Y. Wang, Mangeng Cheng, Donald Baldwin, John W. Tobias, Stephen J. Schuster, Anders Woetmann, Qian Zhang, Suzanne D. Turner, Niels Ødum, Mariusz A. Wasik

Abstract: Anaplastic lymphoma kinase (ALK) physiologically expressed only by nervous system cells displays remarkable capacity to transform CD4+ T lymphocytes and other types of non-neural cells. Here we report that activity of nucleophosphmin (NPM)/ALK chimeric protein, the dominant form of ALK expressed in T-cell lymphomas (ALK+TCL), closely resembles cell activation induced by interleukin 2 (IL-2), the key cytokine supporting growth and survival of normal CD4+ T lymphocytes. Direct comparison of gene expression by A…

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