Malignant transformation arising from mature cystic teratoma of the ovary: A report of six cases

Ülker, Volkan; Numanoğlu, Ceyhun; Akbayır, Özgür; Akyol, Alpaslan; Tunçel, Ayça; Akça, Aysu; Aydın, Övgü

doi:10.1111/j.1447-0756.2011.01797.x

Cited by 44 publications

(41 citation statements)

References 16 publications

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“…In two-thirds of cases, mature elements reflecting differentiation into normally derived cells from all three embryonic germ layers are present. However, any of these constituents has the potential to undergo malignant transformation and the incidence of such cases was reported to be 1–2% in mature ovarian teratomas (6, 7). The most common histologic type of malignant transformation in ovarian teratoma is squamous-cell carcinoma, reported in 70–80% of cases; other types of differentiation including adenocarcinoma, melanoma, and carcinoid tumor, are relatively rare (7, 8).…”

Section: Introductionmentioning

confidence: 99%

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case

et al. 2014

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We report a case of adenocarcinoma arising from a sacrococcygeal mature teratoma in an adult female. A 62-year-old female was diagnosed with a presacral tumor 10 years ago. Pelvic computed tomography (CT) demonstrated a presacral heterogeneous tumor, containing multiloculated cystic area and enhanced solid component with calcification. Percutaneous needle biopsy for the solid component of the tumor identified an adenocarcinoma and the patient was diagnosed as having a sacrococcygeal teratoma with malignant transformation. Abdomino-sacral rectal resection with sacral amputation at the upper edge of the S5 was performed. The pathological diagnosis was adenocarcinoma derived from a mature teratoma. The tumor cells had infiltrated the rectal wall. After 7 months, a follow-up CT demonstrated swelling of the right inguinal lymph nodes and a right inguinal lymphadenectomy was performed. Pathological examination showed metastatic lymph nodes. The patient is doing well 21 months after the second surgery, with no signs of recurrence.

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Section: Introductionmentioning

confidence: 99%

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case

et al. 2014

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“…Kist içeriğinin batın içerisine dökülmesinde korkulan diğer bir durum malign olabilecek bir dermoid kist te bu hücrelerin batına yayılması ve evreyi yükseltmesidir. Bundan dolayı da kist içeriğinin rüptüre edilmemesi için özen gösterilmelidir (14). Fertilitesini tamamlamış perimenapozal dönemdeki hastalarda yada postmenapozal hastalarda ooferektomi uygulanabilir.…”

Section: Discussionunclassified

“…Fertilitesini tamamlamış perimenapozal dönemdeki hastalarda yada postmenapozal hastalarda ooferektomi uygulanabilir. Ayrıca hızlı büyüyen kistlerde malign olma olasılığı dikkatle değerlendirilmeli ve gerekirse ooferektomi uygulanmalıdır (14). Malign teratomlar daha çok postmenapozal dönemde görülebilmelerine rağmen nadirde olsa genç hastalarda da görülebileceği unutulmamalıdır.…”

Section: Discussionunclassified

Analysis of Laparoscopic Treatment of Dermoid Cysts in Our Clinic

Salman¹,

Yumru²,

Duman³

et al. 2014

JAREM

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ÖZETAmaç: Bizim bu çalışmadaki amacımız, laparoskopik olarak tedavi edilen matür kistik teratom olgularının retrospektif olarak değerlendirip sunmak ve kist içerği batına dökülen hastalarda ne gibi komplikasyonlar gelişebileceğini irdelemektiYöntemler: Kliniğimizde 2008 ile 2014 yılları arasında laparoskopik olarak tedavi edilen matür kistik teratom olguları retrospektif olarak analiz edildi. Laparoskopi sırasında kistektomi yada ooferektomi yapıldığı ve hangi hastalarda kist rüptürü oluştuğuna bakıldı. Kist rüptürü oluşan hastalarda posoperatif komplikasyon oluşup oluşmadığına bakıldı. Postoperatif komlikasyonların nasıl yönetldiğine bakıldı.Bulgular: Toplam 22 hastanın 15'ine laparoskopik kistektomi yapılırken 7 hastaya laparoskopik ooferektomi uygulandı. Laparoskopik kist eksizyonu yapılan toplam 8 hastanın kist içeriği batına döküldü, bu hastalardan Sadece 1 tanesinde postoperatif komplikasyon gelişti, bu hasta hospitalize edilip medikal olarak tedavi edildi.Sonuç: Laparoskopik yöntem dermoid kist vakalarında tercih edilecek tedavi yöntemidir. Bizim çalışmamızda 15 hastaya laparoskopik kist eksizyonu uygulanırken 7 hastaya laparoskopik ooferektomi uygulandı. Kistektomi uygulanan 8 hastada kist rüptürü oluştu. Kist rüptürü oluşan 1 hastada postoperatif komplikasyon gelişti ve medikal olarak tedavi edildi. Kist içeriği batına dökülecek olursa iyice temizlenmelidir ve batın serum fizyolojik ile yıkanmalıdır. Eksize edilen kistin endobag kullanarak dışarıya çıkarılması kist içeriğinin batın içine dökülmesine engel olabilir. Laparoskopik yöntem matür kistik teratomların tedavisinde seçilecek ilk yöntem olmalıdır. Genç hastalarda overler mümkün olduğunca korunmaya çalışılmalıdır. İnfertilitesini tamamlamış perimenapozal hastalarda ooferektomi yapılabilir. (JAREM 2014; 2: 55-7) Anahtar Sözcükler: Laparoskopi, dermoid kist, kist rüptürü ABSTRACT Objective: Our aims are to present patient data in the laparoscopic management of mature cystic teratomas; 22 cases of mature cystic teratoma were managed laparoscopically, 15 cases of mature cystic teratomas were managed by laparoscopic cystectomy, and 7 patients with mature cystic teratomas were managed by laparoscopic oophorectomy.Methods: Review of cases of women with mature cystic teratoma who underwent laparoscopic surgery in our clinic from 2008 to 2014. The medical records were searched for age, presenting symptoms, investigations, operative reports, postoperative hospital stay, and complications. Surgery was performed using a laparoscopic approach with a 10-mm port placed in the umbilicus through which a 10 mm 0-degree telescope was used. Two 10-mm and 5-mm working ports were used in the right and left iliac fossae. Initially, the whole peritoneal cavity was inspected as a whole to confirm the diagnosis, exclude malignancy, and inspect the contra-lateral ovary. If the ovary was twisted, it was untwisted, and after stabilizing the ovary, a superficial incision was made with diathermy on the anti-mesenteric border. The incision was gently enlarged to separate the c...

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“…[8] . Due to the high density of ectoderm in these tumors, not surprisingly the most common malignant tumor arising from them is squamous cell carcinoma(SCC), [2,7] while various adenocarcinomas, carcinoid tumors, melanomas and various soft tissue sarcomas have also been reported. [2,4,9] CASE REPORT: A 36 years old female presented with the complaints of abdominal pain, abdominal fullness and difficulty in periods since 6 months.…”

Section: Introductionmentioning

confidence: 99%

“…[1,3] The potential of undergoing malignant transformation(one or more of the three different mature elements of MCTs) is present, typically in postmenopausal women, with a frequency of 0.17-3%. [6,7] Most of MCTs are detected 10-15 years before secondary malignant transformation possibly as a result of exposure in different pelvic carcinogens which trigger malignant changes in mature tissue. [8] .…”

Section: Introductionmentioning

confidence: 99%

Adeno - Squamous Carcinoma Ar Ising in Mature Cystic Teratoma: A Rare Case Report

Shukla¹,

Nigám²,

Rai³

et al. 2015

jemds

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ABSTRACT:The most frequent ovarian germ cell tumours are mature cystic teratoma (MCTs), comprising 10-25% of all ovarian neoplasms. Malignant transformation in a mature cystic teratoma of the ovary is a rare complication. Squamous cell carcinoma is the most common transformation followed by adenocarcinoma. CASE REPORT: A 36 year old female presented with abdominal pain, fullness, difficulty in periods since 6 months. According to examination and CECT abdomen 13.5x13cm mass is found on the left adnexal region. Patient underwent oophrectomy. According to histopathological diagnosis, adenosquamous carcinoma arising in mature cystic teratoma is diagnosed as a reason for the mass in the left adnexa of the patient.

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Malignant transformation arising from mature cystic teratoma of the ovary: A report of six cases

Cited by 44 publications

References 16 publications

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case

Adenocarcinoma Arising from Sacrococcygeal Mature Teratoma in an Adult Female: Report of a Case

Analysis of Laparoscopic Treatment of Dermoid Cysts in Our Clinic

Adeno - Squamous Carcinoma Ar Ising in Mature Cystic Teratoma: A Rare Case Report

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