Malignant Teratoid Medulloepithelioma in an Adult

Abstract

A 50-year-old man presented with a reddish, well-vascularized mass in the region of a nasal iridodialysis of his left eye, pushing the whole iris in this sector forwards; the mass had a pinkish, partly cystic appearance in the pupil. The tumour was transparent on diaphanoscopy. A-scan sonography revealed a solid tumour of the ciliary body with partial retinal detachment suggesting a malignant melanoma. Fluorescein biomicroscopy did not confirm this suspicion. The enucleated eye demonstrated a malignant teratoid medulloepithelioma of the whole nasal and lower ciliary body, infiltrating the deep iris stroma, the anterior choroid, the neighbouring vitreous body and spreading along the inner retinal surface back to the equator of the eye. The occurrence of medulloepithelioma in adult and senior persons is rather exceptional and this is the reason for this publication.

Malignant Ocular Medulloepithelioma Diagnosed in an Adolescent Female at a Tertiary Health Facility in Southwestern Nigeria: A Case Report and Review of the Literature

“…About 75-90% of the tumours manifest in the first decade of life [20]. However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24].…”

“…However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24]. There appears to be no gender or racial predilection [9,12,20,21].…”

Malignant Ocular Medulloepithelioma Diagnosed in an Adolescent Female at a Tertiary Health Facility in Southwestern Nigeria: A Case Report and Review of the Literature

“…About 75-90% of the tumours manifest in the first decade of life [20]. However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24].…”

“…However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24]. There appears to be no gender or racial predilection [9,12,20,21].…”

Characteristics, management, and outcome of ocular medulloepithelioma: systematic review of literature and case report

“…Kaliki et al [10], in an analysis of 41 cases of OM from the USA and India, found that 85% of patients were children; similarly, in our systematic review of 177 patients including the 41 patients described in that study, the mean age at diagnosis was nine years, which is older than the age of diagnosis of retinoblastoma. However, the possibility of medulloepithelioma still exists in adults [10,[15][16][17][18]. It is not known if this later diagnosis of OM compared to retinoblastoma is due to delayed *For the sake of calculating the percentage for any outcome in this analysis when the outcome measure was not available for group of the patients, we referred the percentage to the number of patients with known outcome, excluding those with unknown outcome; **Others: cryotherapy in 5 cases, palliative chemotherapy in 5 cases, and exenteration in 7 cases; ***NA -these outcome data were not reported in the original article reporting about these patients www.journals.viamedica.pl/ophthalmology_journal event of tumour initiation or due to delayed diagnosis.…”

Intraocular malignant teratoid medulloepithelioma in an adult: clinicopathological case report and review of the literature

“…In the majority of these cases, a significant delay between the onset of first symptoms and final diagnosis was reported (Zimmerman et al 1972; Broughton & Zimmerman 1978; Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996; Jumper et al 1999). A possible explanation for the late presentation of medulloepithelioma, a tumour considered to be congenital, might be that a benign version of embryonal tumour is present from early life, but its transformation into an aggressive, symptomatic form occurs later (Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996). In our patient, an unexplained retinal detachment was observed at the age of 16 years, causing the loss of vision in the left eye, and 28 years later malignant teratoid medulloepithelioma was diagnosed.…”

Malignant Ocular Medulloepithelioma Diagnosed in an Adolescent Female at a Tertiary Health Facility in Southwestern Nigeria: A Case Report and Review of the Literature

“…About 75-90% of the tumours manifest in the first decade of life [20]. However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24].…”

“…However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24]. There appears to be no gender or racial predilection [9,12,20,21].…”

Characteristics, management, and outcome of ocular medulloepithelioma: systematic review of literature and case report

“…Kaliki et al [10], in an analysis of 41 cases of OM from the USA and India, found that 85% of patients were children; similarly, in our systematic review of 177 patients including the 41 patients described in that study, the mean age at diagnosis was nine years, which is older than the age of diagnosis of retinoblastoma. However, the possibility of medulloepithelioma still exists in adults [10,[15][16][17][18]. It is not known if this later diagnosis of OM compared to retinoblastoma is due to delayed *For the sake of calculating the percentage for any outcome in this analysis when the outcome measure was not available for group of the patients, we referred the percentage to the number of patients with known outcome, excluding those with unknown outcome; **Others: cryotherapy in 5 cases, palliative chemotherapy in 5 cases, and exenteration in 7 cases; ***NA -these outcome data were not reported in the original article reporting about these patients www.journals.viamedica.pl/ophthalmology_journal event of tumour initiation or due to delayed diagnosis.…”

Intraocular malignant teratoid medulloepithelioma in an adult: clinicopathological case report and review of the literature

“…In the majority of these cases, a significant delay between the onset of first symptoms and final diagnosis was reported (Zimmerman et al 1972; Broughton & Zimmerman 1978; Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996; Jumper et al 1999). A possible explanation for the late presentation of medulloepithelioma, a tumour considered to be congenital, might be that a benign version of embryonal tumour is present from early life, but its transformation into an aggressive, symptomatic form occurs later (Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996). In our patient, an unexplained retinal detachment was observed at the age of 16 years, causing the loss of vision in the left eye, and 28 years later malignant teratoid medulloepithelioma was diagnosed.…”

Malignant Ocular Medulloepithelioma Diagnosed in an Adolescent Female at a Tertiary Health Facility in Southwestern Nigeria: A Case Report and Review of the Literature

“…About 75-90% of the tumours manifest in the first decade of life [20]. However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24].…”

“…However, there are well-documented cases of medulloepithelioma occurring in aduldhood [22][23][24][25]. The age of presentation has been known to vary between 6 months and 79 years [9,12,[22][23][24]. There appears to be no gender or racial predilection [9,12,20,21].…”

Characteristics, management, and outcome of ocular medulloepithelioma: systematic review of literature and case report

“…Kaliki et al [10], in an analysis of 41 cases of OM from the USA and India, found that 85% of patients were children; similarly, in our systematic review of 177 patients including the 41 patients described in that study, the mean age at diagnosis was nine years, which is older than the age of diagnosis of retinoblastoma. However, the possibility of medulloepithelioma still exists in adults [10,[15][16][17][18]. It is not known if this later diagnosis of OM compared to retinoblastoma is due to delayed *For the sake of calculating the percentage for any outcome in this analysis when the outcome measure was not available for group of the patients, we referred the percentage to the number of patients with known outcome, excluding those with unknown outcome; **Others: cryotherapy in 5 cases, palliative chemotherapy in 5 cases, and exenteration in 7 cases; ***NA -these outcome data were not reported in the original article reporting about these patients www.journals.viamedica.pl/ophthalmology_journal event of tumour initiation or due to delayed diagnosis.…”

Intraocular malignant teratoid medulloepithelioma in an adult: clinicopathological case report and review of the literature

“…In the majority of these cases, a significant delay between the onset of first symptoms and final diagnosis was reported (Zimmerman et al 1972; Broughton & Zimmerman 1978; Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996; Jumper et al 1999). A possible explanation for the late presentation of medulloepithelioma, a tumour considered to be congenital, might be that a benign version of embryonal tumour is present from early life, but its transformation into an aggressive, symptomatic form occurs later (Carrillo & Streeten 1979; Litricin & Latkovic 1985; Shields et al 1996). In our patient, an unexplained retinal detachment was observed at the age of 16 years, causing the loss of vision in the left eye, and 28 years later malignant teratoid medulloepithelioma was diagnosed.…”