Malignant syphilis in an immunocompetent female patient

Requena, Camila Bueno; Orasmo, Cínthia Rosane; Ocanha, Juliana Polizel; Barraviera, Silvia Regina Catharino Sartore; Marques, Mariângela Esther Alencar; Marques, Silvio Alencar

doi:10.1590/abd1806-4841.20143155

Cited by 26 publications

(31 citation statements)

References 8 publications

(13 reference statements)

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“…Early malignant syphilis (EMS) was described by Bazin in 1859 and Dubuc in 1864 as a nodular variant of secondary syphilis with aggressive development. 6 , 8 - 10 Its diagnosis was common in the seventeenth century, but its incidence has subsequently declined. 4 Years before the discovery of penicillin, in times of war and famine, EMS was observed in cachectic patients with tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

“…Although the current treatment for secondary syphilis consists of two penicillin G benzathine injections at a dose of 2,400,000 IU at weekly intervals, in our case we chose the total dose of 7,200,000 IU, as some authors recommend increasing the dose in case of HIV coinfection or in cases of immunosuppression. 1 - 4 , 6 , 8 , 10 For resistant cases or relapses, prolonged therapy with high doses of penicillin is suggested. 6…”

Section: Discussionmentioning

confidence: 99%

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Early malignant syphilis

Ortigosa

Bendazzoli²,

Barbosa³

et al. 2016

An. Bras. Dermatol.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early malignant syphilis

Ortigosa

Bendazzoli²,

Barbosa³

et al. 2016

An. Bras. Dermatol.

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“…Congenital Syphilis may be recent or late, with mean, can have less or more than two years of evolution, respectively. Infection acquired when untreated, up to 35% will evolve to cure, 35% to latent form, and the remainder will progress to the tertiary stage [4] [5] [6]. Congenital syphilis is responsible for high rates of neonatal death, fetal death and miscarriage.…”

Section: Introductionmentioning

confidence: 99%

Secondary Syphilis in Man: Prozone Effect

Anjos¹,

Costa²,

Miguel³

et al. 2018

JBM

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Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.

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“…The exact mechanism of malignant syphilis is not yet known. Before the outbreak of HIV infection, the frequency was 0.12% to 0.36% and now about 7% . It seems that the pathogenic interaction between HIV and T. pallidum may reduce the immunologic response to treponemal infection .…”

mentioning

confidence: 99%

“…Before the outbreak of HIV infection, the frequency was 0.12% to 0.36% 3 and now about 7%. 4 It seems that the pathogenic interaction between HIV and T. pallidum may reduce the immunologic response to treponemal infection. 5 However, it has also been described in immunocompetent patients.…”

mentioning

confidence: 99%