A 80-year-old woman was hospitalized due to anemia and fever. Computed tomography depicted a solitary concentric, sharply marginated lesion of the spleen. Laparotomy identifi ed a creamy-white soft tumor. Histopathological examination confi rmed the diagnosis of non-Hodgkin B-cells anaplastic lymphoma. Extended range of pathological manifestations explains the variety of radiological appearances and diffi culty in accurate diagnostic process of primary splenic lymphoma.