Malignant Melanoma with Pseudocarcinomatous Hyperplasia—An Entity That Can Simulate Squamous Cell Carcinoma

Kamino, Hideko; Tam, Sam; Alvarez, L

doi:10.1097/00000372-199010000-00003

Cited by 38 publications

(28 citation statements)

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“…The exact etiology of bidirectional/dual differentiation is unclear although several hypotheses have been proposed. 13 Our case showed no evidence of pseudoepitheliomatous hyperplasia. 10 Other proposed theories include aberrant expression of immunohistochemical markers by the neoplastic cells.…”

Section: Discussionmentioning

confidence: 47%

Squamomelanocytic Tumor

Jour

Paniz‐Mondolfi²,

Reidy

et al. 2014

The American Journal of Dermatopathology

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We report a case of combined squamomelanocytic tumor of the skin. Clinically, the lesion was felt to be a squamous cell carcinoma. Histologically, it was characterized by large epithelioid cells admixed with basaloid cells with central squamous differentiation. Immunohistochemical staining showed both cell populations to be reactive with Melan A, BEREP4, and Pan Keratins. Ultrastructural studies revealed simultaneous features of squamous differentiation (dense cytoplasmic tonofilaments with well-developed desmosomes) and melanocytic differentiation (mature/pigmented melanosomes) in the same cell population. This is the second reported case in the English literature with documented biphenotypic or divergent differentiation at the ultrastructural level. The behavior of squamomelanocytic tumor is uncertain given the rarity of reported cases.

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Section: Discussionmentioning

confidence: 47%

Squamomelanocytic Tumor

Jour

Paniz‐Mondolfi²,

Reidy

et al. 2014

The American Journal of Dermatopathology

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“…Malignant melanoma with pseudocarcinomatous hyperplasia (MMPH) is another tumor to consider in the differential diagnosis, since it shares with PSCC an abnormal proliferation of keratinocytes and melanocytes. The tumors differ however, in that the epithelial proliferation (pseudocarcinomatous hyperplasia) in MMPH is reactive in nature and occurs in response to an underlying malignant melanoma, 20 whereas the epidermal component in PSCC is frankly malignant admixed with benign dendritic melanocytes. It is important to make this distinction, since these tumors have significantly different prognoses.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Squamous Cell Carcinoma

Satter

2007

The American Journal of Dermatopathology

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Although dendritic, melanin-containing melanocytes can be seen in a variety of epithelial neoplasms, only 0.01% to 7% of all squamous cell carcinomas (SCC) are pigmented. Furthermore, most reported cases have occurred in the oral and ocular mucosa, with relatively few cases reported to originate in the skin. Herein we report a case of a 61-year-old Caucasian male who presented with a large blue-black nodule on his left cheek, clinically suspicious for a melanoma; however, histological evaluation revealed an acantholytic pigmented squamous cell carcinoma. Previous cases are reviewed and the clinical and histological differential diagnoses are discussed.

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“…In these 2 retrospective clinicopathological studies, the contradictory epidemiologic data that were found probably reflects an insufficient number of cases because this is not a common type of melanoma. To date, only extremely rare additional cases have been reported, such as melanomas associated with pseudocarcinomatous hyperplasia 9,10 or other entities that combine biphenotypic characteristics in the same neoplasm. [11][12][13] The histopathological appearance of our case obviously differs from verrucous-hyperkeratotic melanoma, since the lack of epidermal hyperplasia and hyperkeratosis is evident.…”

Section: Commentmentioning

confidence: 99%