Malignant melanoma revealed by testicular metastasi.

Dusaud, M.; Adjadj, Lucille; Debelmas, Alexandre; Souraud, Jean Baptiste; Durand, Xavier

doi:10.1016/j.ijscr.2015.05.026

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Noteworthy, testicular metastases do not appear to be associated with the presence of clinical symptoms in human patients, representing an incidental finding during postmortem investigation [ 19 ]. Indeed, malignant melanomas that metastasise to the testis are the most aggressive and life-threatening, representing an advanced stage of neoplastic disease with a generally poor prognosis [ 20 ]. Mortality appears extremely high and rapid, with survival of less than 12 months, which explains why most of the data derive from postmortem investigations [ 19 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Malignant Melanoma with Testicular Metastases in a Wild Rabbit (Oryctolagus cuniculus)

Abbate,

Palazzolo,

Ieni

et al. 2023

Veterinary Sciences

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Melanocytic skin tumours have been rarely described in pet rabbits, and exposure to UV light in sparsely haired areas has been hypothesised to play a cancerogenic role. Here, we describe a case of cutaneous malignant melanoma arising from the skin of the scrotum in an 8-year-old male wild rabbit, with testicular metastases as an unusual metastatic site for melanoma reported in humans to date. The tumour was nearly 5 cm in size, firm, and highly pigmented, with multifocal superficial ulcerations and large areas of intratumoural necrosis. The adjacent testis was 1.5 cm, multinodular, and black, obscuring tissue morphology. Histologically, the dermis was expanded by an infiltrative, densely cellular neoplasm composed of nests and sheets of polygonal to spindle neoplastic melanocytes, supported by scant fibrovascular stroma. Neoplastic cells showed intermediate N/C ratio, moderate basophilic cytoplasm, often obscured by abundant brownish granular pigment, and eccentric nuclei with prominent nucleoli. Cellular pleomorphism and nuclear atypia were severe, and high mitotic activity was observed. Diffuse dermal lymphovascular invasion was also observed. The testis was delimited by a thin tunica albuginea, and the parenchyma was largely obscured in its morphology by densely packed neoplastic cells. Seminiferous tubules, lined with a thin basement membrane and containing neoplastic and scattered spermatogenic cells, were occasionally observed. Neoplastic cells within the skin and the testis were positive for HMB-45, Melan-A, and S-100. The growing popularity of rabbits as pets allows for a greater ability to accumulate data on the spontaneous occurrence of tumours in these animals. Furthermore, descriptions of the biological aspects of spontaneously occurring tumours may serve to improve current knowledge in animal species and humans in which the same neoplasm may occur.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Malignant Melanoma with Testicular Metastases in a Wild Rabbit (Oryctolagus cuniculus)

Abbate,

Palazzolo,

Ieni

et al. 2023

Veterinary Sciences

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“…The testicle is a rare site for the metastatic localization of other tumors. Some literature reports include prostate [141], lung [142], gastrointestinal tumors [143,144], melanoma [145], pancreas [146], kidneys [147], bladder [148], thyroid [149], and neuroblastoma [150].…”

Section: Metastasesmentioning

confidence: 99%

Multiparametric Ultrasound for Diagnosing Testicular Lesions: Everything You Need to Know in Daily Clinical Practice

Pozza,

Tenuta,

Sesti

et al. 2023

Cancers

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Background: Ultrasonography (US) represents the gold standard imaging method for the assessment of testicular lesions (TL). The gray-scale (GSUS) and color-Doppler (CDUS) ultrasound examination allow sonographers to investigate the size, margins, echotexture, and vascular features of TLs with the aim to differentiate benign from malignant lesions. Recently, the use of contrast-enhanced US (CEUS) and sonoelastography (SE) has led to further improvements in the differential diagnosis of TL. Although GSUS and CDUS are often sufficient to suggest the benign or malignant nature of the TL, CEUS can be decisive in the differential diagnosis of unclear findings, while SE can help to strengthen the diagnosis. The contemporary combination of GSUS, CDUS, CEUS, and SE has led to a new diagnostic paradigm named multiparametric US (mp-US), which is able to provide a more detailed characterization of TLs than single techniques alone. This narrative and pictorial review aimed to describe the mp-US appearance of several TLs. Methods: An extensive Medline search was performed to identify studies in the English language focusing on the mp-US evaluation of TLs. Results: A practical mp-US “identity card” and iconographic characterization of several benign and malignant TLs is provided herein. Conclusions: The mp-US characterization of TL reported herein can be useful in daily clinical practice.

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“…In addition, the nonspecific characteristics of the primary tumor of testicular metastases pose a challenge for diagnosis. According to previously reported cases of testicular metastases, the tumors usually occur in men with prostate cancer [ 4 ], malignant melanoma [ 5 ], renal cell carcinoma [ 6 ], colonic carcinoma [ 7 ], lung carcinoma [ 8 ], etc. However, the specific mechanisms of testicular metastasis in these tumors are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Ascending colon cancer metastasized to the right testicle: a case report

Gao,

Li,

Zhu

2024

J Med Case Reports

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Background Testicular metastasis from malignant solid tumors is extremely rare. It is usually found by chance during autopsy or pathological examination of testicular specimens. Therefore, we consider it necessary to report our patient’s case of testicular metastasis from colon cancer. Case presentation We report a 61-year-old Han Chinese male patient who presented to our clinic with progressive painless swelling of the right testicle for 2 years. Positron emission tomography–computed tomography scans showed increased 18F-fluorodeoxyglucose metabolism in the right testicle, possibly owing to distant metastasis. His previous medical history suggested that he had undergone laparoscopic-assisted right hemicolectomy for ascending colon cancer 4 years ago. Considering the ascending colon cancer metastasis to the right testicle, we performed a right radical testicular resection through an inguinal approach. Postoperative histological examination showed intestinal metastatic adenocarcinoma. Conclusion Colon cancer metastasis to the testes is uncommon. The clinical and imaging manifestations of this tumor are nonspecific, so the diagnosis relies on postoperative pathology. If testicular metastasis is found, treatment principles for advanced colon cancer should be followed.

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Malignant melanoma revealed by testicular metastasi.

Abstract: HighlightsTesticular tumor epidemiology after 65 years old is different than in young adult.Testicular metastasis of malignant melanoma is rare.Testicular metastasis of a malignant melanoma demonstrate the severity of the disease.

Cited by 5 publications

References 11 publications

Cutaneous Malignant Melanoma with Testicular Metastases in a Wild Rabbit (Oryctolagus cuniculus)

Cutaneous Malignant Melanoma with Testicular Metastases in a Wild Rabbit (Oryctolagus cuniculus)

Multiparametric Ultrasound for Diagnosing Testicular Lesions: Everything You Need to Know in Daily Clinical Practice

Ascending colon cancer metastasized to the right testicle: a case report

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