1980
DOI: 10.1001/archderm.116.6.696
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Malignant melanoma originating from intradermal nevi. A clinicopathologic entity

Abstract: Two cases of malignant melanoma arising in preexisting intradermal nevi without a junctional element are described. These cases and the two known to have been reported previously demonstrate similar clinical and morphologic findings. These include an innocuous gross appearance, a nodular growth pattern, and deep levels of invasion. It appears that the origin of the tumor in the dermis conceals malignant transformation. The consequent time lapse and the dermal position of the lesion favor deep penetration of th… Show more

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Cited by 10 publications
(11 citation statements)
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“…Sixty percent of the esophageal melanomas described by Kreuser [27] failed to fulfill this criterion, and he relied instead on the presence of concomitant benign melanocytosis as evidence of their primary nature. It is well known that some malignant melanomas arise purely intradermally from a congenital nevus or blue nevus [28][29][30].…”
Section: Discussionmentioning
confidence: 99%
“…Sixty percent of the esophageal melanomas described by Kreuser [27] failed to fulfill this criterion, and he relied instead on the presence of concomitant benign melanocytosis as evidence of their primary nature. It is well known that some malignant melanomas arise purely intradermally from a congenital nevus or blue nevus [28][29][30].…”
Section: Discussionmentioning
confidence: 99%
“…This may be specific in cases with malignant melanoma from an intradermal nevus, but the reason remains unclear. In 3 of the 4 previous reports, malignant melanomas developed beneath nests of nevus cells [1, 2, 3], while in the fourth report, it was shown that nevus cells were scattered throughout the nodule and blended with melanoma cells [5]. In the present case, melanoma developed upward from the nest of the intradermal nevus, and no junctional activity was seen.…”
Section: Discussionmentioning
confidence: 44%
“…In the cases reported, the melanoma cells were usually located beneath the intradermal nevus cells [1, 2, 3]. However, in the case described here, melanoma cells were located above the intradermal nevus without showing junctional activity, and a transitional zone was detected between nevus and melanoma cells.…”
Section: Introductionmentioning
confidence: 58%
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