Malignant melanoma of mucous membranes. A clinicopathologic study of 13 cases in Japanese patients

Kato, Taizo

doi:10.1001/archderm.123.2.216

Cited by 27 publications

(15 citation statements)

References 1 publication

(1 reference statement)

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“…17 In a smaller series of 13 mucosal melanomas from similarly diverse anatomic sites, the authors reported more varied histology, including 58% lentiginous, 23% NM, and 15% SSM. 23 A similar distribution was found among 198 melanomas isolated to the vulvar region, in which 57% were lentiginous, 22% NM, 12% unclassified, and 4% SSM. 24 Lentigo maligna melanoma does not occur on sun-protected mucosal surfaces but may occur on the keratinized sun-exposed surface of the lip, although the incidence is not well documented.…”

Section: Histologicalsupporting

confidence: 57%

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Merkel

Gerami

2017

Laboratory Investigation

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In most cases of cutaneous melanoma, ultraviolet (UV) radiation is recognized as a prominent risk factor. Less is known regarding the mechanisms of mutagenesis for melanoma arising in sun-protected sites, such as acral and mucosal melanoma. Acral and mucosal melanoma share many common features, including a late age of onset, a broad radial growth phase with prominent lentiginous growth, the presence of field cancerization cells, and, in most cases, lack of a precursor nevus. In addition to early chromosomal instability, many of the same genes are also involved in these two distinct melanoma subtypes. To better understand non-UV-mediated pathogenesis in melanoma, we conducted a joint literature review of clinical, histological, and molecular features in acral and mucosal melanoma. We also reviewed the current literature regarding aberrations in KIT, PDGFRA, TERT, and other commonly involved genes. By comparing common features of these two subtypes, we suggest potential mechanisms underlying acral and/or mucosal melanoma and offer direction for future investigations.

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Section: Histologicalsupporting

confidence: 57%

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Merkel

Gerami

2017

Laboratory Investigation

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“…Previous reports indicate that the incidence of malignant melanoma in Japanese has increased recently and that the proportion of acral and mucosal melanomas in malignant melanoma of Japanese is higher than that in Caucasians [35][36][37]. However identification of genetic alterations including KIT in the distinct melanoma subtype among different ethnic groups has rarely been evaluated.…”

Section: Discussionmentioning

confidence: 99%

Anorectal melanoma with a KIT-activating mutation, which is a target for tyrosine kinase inhibitor

et al. 2010

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Recent advances in our understanding of the genetic mutations associated with melanoma have led to the classification of distinct melanoma subtypes. A number of reports have consistently demonstrated that mucosal and acral melanomas more commonly harbor KIT-activating mutations than do other subtypes. Success in treating gastrointestinal stromal tumors with imatinib has led to speculation that KIT-mutated melanoma might also be effectively managed using this approach. A 78-year-old woman presented with a 4-month history of rectal bleeding. A colonoscopy revealed a black polypoid mass, 30 mm in diameter, originating near the dentate line, and a biopsy revealed malignant melanoma. Computed tomography showed multiple liver and lung metastases. A KIT mutation analysis showed the L576P mutation in exon 11. The patient did not want to undergo chemotherapy including a tyrosine-kinase inhibitor, so palliative radiotherapy for rectal symptoms was performed, but the patient died 4 months later due to disease progression. We describe the first case of anorectal melanoma with a KIT-activating mutation in Japan and summarize findings from the literature regarding the efficacy of KIT kinase inhibitors on this melanoma subtype.

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“…Some studies reported similarities between OMM and acral lentiginous melanoma (ALM) with a radial growth phase both clinically and histologically [26,34]. Others regarded OMM separately from cutaneous melanoma because of the difference in the prognosis [13]. Nevertheless, WESTOP has stated that OMM appeared similar to ALM and less frequently to nodular melanoma when no in situ component was evident [1].…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma

et al. 2005

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The basement membrane (BM) is mainly composed of type IV collagen, which is composed of triple combinations of six distinct alpha (alpha) chains in a tissue-specific manner. The six collagen chain-specific antibodies (alpha1-alpha6) were used to examine the BMs of the oral epithelium (OE) and tumor clusters in oral mucosal melanoma (OMM). Eight OMM cases were examined. Results showed that the alpha1 and alpha2 chains were constantly detected at the BM of the normal OE as well as at the OE with atypical melanocytic proliferation and in invasive melanoma with nodular nests. The alpha1 and alpha2 chains were intermittently detected in in situ OMM, early invasive OMM and advanced invasive OMM with sheet-like nests. Gradual loss of alpha5 and alpha6 from the OE with atypical melanocyte through in situ OMM and early invasive OMM was observed. These findings suggest that changes in the immunolocalization and distribution patterns of type IV collagen alpha chains are associated with the progression of OMM. The distribution pattern of type IV collagen alpha chain varies depending on the architecture of the nest.

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Malignant melanoma of mucous membranes. A clinicopathologic study of 13 cases in Japanese patients

Cited by 27 publications

References 1 publication

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Anorectal melanoma with a KIT-activating mutation, which is a target for tyrosine kinase inhibitor

Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma

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