Malignant Melanoma Arising in a Radiotherapy Field: Report of Two Cases and Review of the Literature

Trefzer, Uwe; Voit, Christiane; Milling, Annett; Audring, Heike; Sterry, Wolfram

doi:10.1159/000068891

Cited by 15 publications

(12 citation statements)

References 39 publications

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“…In Austria, routine health data are usually available per district and UVR dose data only for nine locations. In the current study, we assumed a latency period for melanoma of at least 10 years based on the respective literature, with altitude and inter-annual variability as main predictors of melanoma risk-associated UVR exposure [27,28,29,30,31]. …”

Section: Instructionmentioning

confidence: 99%

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Haluza

Simic

Moshammer

2014

IJERPH

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Annual solar ultraviolet radiation (UVR) is mostly determined by latitude and altitude. Over the last decades, increasing UVR ground levels have been observed. Exposure to UVR is associated with a life-time risk to develop melanoma, a malign skin cancer. Thus, we hypothesized that melanoma incidence in Austria is associated with altitude of place of living and time of diagnosis. We investigated this hypothesis in an ecological study by district and year for Austrian melanoma incidence (1990–2010) and mortality (1970–2011) data. As expected, incidence rates increased with altitude (about 2% per 10 m) and year (about 2%). Additionally, melanoma incidence rates were about 50% higher in urban than in rural districts. In contrast, mortality rates decreased with altitude (for males: 0.4% per 10 m, for women: 0.7% per 10 m, respectively). The observed discrepancy between incidence and mortality data could partly be explained by melanoma diagnosis at earlier tumor stage in districts with higher altitude. Possible reasons for this finding include higher awareness of patients, better diagnostic performance of medical professionals working at higher altitudes, or slower tumor growth due to protective effects of sun light-associated vitamin D synthesis.

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Section: Instructionmentioning

confidence: 99%

Temporal and Spatial Melanoma Trends in Austria: An Ecological Study

Haluza

Simic

Moshammer

2014

IJERPH

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“…In general, exposure categories with elevated risks of leukemia had an elevated risk for melanoma [9]. Trefzer et al reported two patients that developed melanoma or melanoma metastases within a radiated field, six and forty-three years after radiation therapy [10]. Similarly, Miracco et al reported two cases of unusual neoplasms secondary to radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Melanoma Arising in a Long-Standing Irradiated Keloid

Fish

Duncan

Gray

et al. 2012

Case Reports in Surgery

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Ionizing radiation has been used therapeutically for a variety of clinical conditions, including treatment of hypertrophic keloids. Keloids may rarely be associated with malignancy, but the use of low-dose ionizing radiation is associated with an increased risk of cutaneous malignancies. We describe a case in which a primary desmoplastic melanoma arose in a long-standing, previously irradiated keloid.

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“…However, it is necessary to continue observations on the clinical course with attention paid to the development of secondary skin cancer [8] .…”

Section: Discussionmentioning

confidence: 99%