Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma

Unilateral adult malignant optic nerve glioma

“…Until now, 44 cases have been described, not including the present case [1,3,4,5,6,7,9,10,11,12,13,14,15,16,17,18,20,22,23,25,26,27,28,29]. They are summarised in Table 1.…”

“…Only one case of adult malignant optic nerve glioma developed 8 years after radiotherapy for a recurrent prolactinoma [13]. In all other cases, no radiotherapy or other potentially tumour-promoting events were noted.…”

Unilateral adult malignant optic nerve glioma

“…Until now, 44 cases have been described, not including the present case [1,3,4,5,6,7,9,10,11,12,13,14,15,16,17,18,20,22,23,25,26,27,28,29]. They are summarised in Table 1.…”

“…Only one case of adult malignant optic nerve glioma developed 8 years after radiotherapy for a recurrent prolactinoma [13]. In all other cases, no radiotherapy or other potentially tumour-promoting events were noted.…”

A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis?

“…It is known that irradiation of the pituitary fossa may induce the development of a sellar or parasellar tumour of non-pituitary origin, such as an osteogenic sarcoma (6), fibrosarcoma (7,8) or glioma (9). Apart from such radiation oncogenesis, it is commonly held that most, if not all, recurrent pi¬ tuitary tumours are expected to show the same histopathological and endocrine features as did the original tumours.…”

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

“…After articles were excluded based on our present inclusion and exclusion criteria, finally 87 articles with a total of 137 (48 neuroepithelial tumors, 37 meningiomas, 52 sarcomas) patients in the 1959–2017 period were included in this review, although data is missing regarding overall survival and type of irradiation in a significant proportion of the reports (Figure 1, Table 1, Supplementary Table S1) [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,…”

Unilateral adult malignant optic nerve glioma

“…Until now, 44 cases have been described, not including the present case [1,3,4,5,6,7,9,10,11,12,13,14,15,16,17,18,20,22,23,25,26,27,28,29]. They are summarised in Table 1.…”

“…Only one case of adult malignant optic nerve glioma developed 8 years after radiotherapy for a recurrent prolactinoma [13]. In all other cases, no radiotherapy or other potentially tumour-promoting events were noted.…”

A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis?

“…It is known that irradiation of the pituitary fossa may induce the development of a sellar or parasellar tumour of non-pituitary origin, such as an osteogenic sarcoma (6), fibrosarcoma (7,8) or glioma (9). Apart from such radiation oncogenesis, it is commonly held that most, if not all, recurrent pi¬ tuitary tumours are expected to show the same histopathological and endocrine features as did the original tumours.…”

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

“…After articles were excluded based on our present inclusion and exclusion criteria, finally 87 articles with a total of 137 (48 neuroepithelial tumors, 37 meningiomas, 52 sarcomas) patients in the 1959–2017 period were included in this review, although data is missing regarding overall survival and type of irradiation in a significant proportion of the reports (Figure 1, Table 1, Supplementary Table S1) [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,…”

Unilateral adult malignant optic nerve glioma

“…Until now, 44 cases have been described, not including the present case [1,3,4,5,6,7,9,10,11,12,13,14,15,16,17,18,20,22,23,25,26,27,28,29]. They are summarised in Table 1.…”

“…Only one case of adult malignant optic nerve glioma developed 8 years after radiotherapy for a recurrent prolactinoma [13]. In all other cases, no radiotherapy or other potentially tumour-promoting events were noted.…”

A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis?

“…It is known that irradiation of the pituitary fossa may induce the development of a sellar or parasellar tumour of non-pituitary origin, such as an osteogenic sarcoma (6), fibrosarcoma (7,8) or glioma (9). Apart from such radiation oncogenesis, it is commonly held that most, if not all, recurrent pi¬ tuitary tumours are expected to show the same histopathological and endocrine features as did the original tumours.…”

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

“…After articles were excluded based on our present inclusion and exclusion criteria, finally 87 articles with a total of 137 (48 neuroepithelial tumors, 37 meningiomas, 52 sarcomas) patients in the 1959–2017 period were included in this review, although data is missing regarding overall survival and type of irradiation in a significant proportion of the reports (Figure 1, Table 1, Supplementary Table S1) [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,…”