Malignant glioma in laboratory workers.

Rutty, Guy N.; Honavar, Mrinalini; Doshi, Bhavesh

doi:10.1136/jcp.44.10.868

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…The choice of the total French population as a reference was justified, since rare forms of cancer were involved. Nevertheless, our results are consistent with those of previous studies as regards the mortality from cancer among scientists potentially exposed to mixtures of chemicals, such as chemists or biologists (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The statistical power of the study only allowed the detection of high risks.…”

Section: Discussionsupporting

confidence: 82%

“…Nevertheless, certain specific cancer sites have repeatedly been found to occur more frequently in these cohorts. They include lymphatic and hematopoietic cancer in general (2, 4, 6, 8, 9, 1 1-14) and lymphosarcoma in particular, as well as brain tumors (5, 9-1 1, 13, 15), for which findings have been supported by case reports of brain tumor clusters among laboratory workers (16,17). Less consistent excesses have also been observed for pancreatic cancer (2,4,13,14) and melanoma (3,12) and bone cancer (11).…”

supporting

confidence: 62%

“…The cases were all subjects identified as having had one of the following diagnoses: non- These types of cancer were chosen a priori as having been linked in some instances with the work environment of chemists and laboratory workers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Cases of decedents (N = 17) were identified from death certificates, and incident cases (N = 6) were gathered from the answers the questionnaire, or from occupational medical records for those who had a file in 1987 but had not answered the questionnaire.…”

Section: Nested Case-referent Studymentioning

confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (I), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158-1144], as was the number of brain cancer cases (SMR 239, 95% CI 48-696). Among the men, mortality from bone cancer was greater than expected (SMR 553,95% CI 62-2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5-331 and microbial genetics (OR 6.7, 95% CI 1.3-35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). C O~~C~U S~O~~S As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested casereferent study.

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Section: Discussionsupporting

confidence: 82%

supporting

confidence: 62%

Section: Nested Case-referent Studymentioning

confidence: 99%

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Cancer risk among workers in biomedical research

Cordier¹,

Mousel²,

Goaster³

et al. 1995

Scand J Work Environ Health

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show abstract

“…Although the toxicity and immediate risks resulting from the manipulation of certain substances are well known, the issue of occupational cancer risk for laboratory workers has only been quite recently explored [Sasco, 1989[Sasco, , 1992. Several studies have been motivated by the observation of cancer clusters [Pleven, 1984;Rutty et al, 1991] in various research institutes during the 1980s.…”

Section: Introductionmentioning

confidence: 99%

Cancer risk in laboratory workers: An emphasis on biological research

et al. 2000

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“…The excess of deaths where the SEG was not known at death (SEG Y), has been divided proportionately in the last column of table 4. Because relatively few farmers or farmers relatives retire from their farms in Ireland, most of the deaths in SEG Y (occupation unknown) were of people living in Dublin or other towns.…”

Section: Resultsmentioning

confidence: 99%