Malignant fibrous histiocytoma in the right portion of the mandible with metastasis in pancreas

Abstract

HighlightsThere is no reported evidence in the literature of malignant fibrous histiocytoma having metastasized in pancreas and stomach.The incidence of Malignant fibrous histiocytoma (MFH) in the mandible is not frequent and incidence risk is only 3% of all MFHs in bones.Metastasis in extrapulmonary locations are not frequent.

Secondary undifferentiated pleomorphic sarcoma of the mandible in a HIV patient who underwent radiotherapy for oral carcinoma

“…tumor size, surgical margins, histopathological grade and tumor presentations (primary or secondary). 3,7,12 RAS have shown 5-year survival rate significantly worse than primary sarcomas, 52% and 73%, respectively. 9 Moreover, UPS of the mandible, regardless of the treatment modality, has an overall 5-year survival rate of 45%.…”

“…4 The oral cavity is rarely affected, and, among bone-deriving UPS, the mandible represents the 3% of localizations. 1,3,4,12,13 From an histopathological point of view, UPS is a highgrade sarcoma with no specific line of differentiation. 6 Multiple immunohistochemical stainings are necessary for excluding any other potential diagnosis such as melanoma (protein S100), Kaposi's sarcoma (D2-40 and HHV-8), lymphoma (CD45), multiple myeloma, bone metastases and other types of mesenchymal tumors (such as osteosarcoma and leiomyosarcoma).…”

“…9 Moreover, UPS of the mandible, regardless of the treatment modality, has an overall 5-year survival rate of 45%. 3,7 A close and lifetime follow-up of UPS localized at the head and neck region is highly recommended, in order to detect early local recurrences, secondary lesions or distant metastases. The latter commonly occur via hematogenous or lymphatic spreading 4 and have been reported in about 25-35% of cases: the lung is the most frequently affected site (90% of cases), followed by bone and liver.…”

“…2 © 2021 Special Care Dentistry Association and Wiley Periodicals LLC UPS is more commonly localized at arms and legs' soft tissues, but can also affect bone, mainly femur, tibia and homer, causing pain, swelling and, in some cases, pathological fractures. 3 UPS rarely affects the head and neck region and it is even more sporadic in the jaw bones. 4,5 UPS of the head and neck usually appears as a painless and firm growing-mass, which infiltrates the surrounding tissues in the absence of pathognomonic signs and symptoms.…”

“…6 Considering the histopathological appearance, five different subtypes have been described: storiform/ pleomorphic, myxoid, giant cell, inflammatory, and angiomatoid. 1,3,7 Angiomatoid and myxoid subtypes are associated to better prognosis, while the giant cell subtype presents the highly aggressive behavior with local growth, local recurrence and distant metastasis. 1 The storiform/ pleomorphic is the most common subtype representing up to 70% of all reported cases.…”