Malignant cutaneous mixed tumor

Devine, P.

doi:10.1001/archderm.120.5.576b

Cited by 12 publications

(4 citation statements)

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“…Given the infiltrative nature of the tumour and presence of satellite nodules, MMS is likely a promising treatment option and should be considered. 12 Our results did not demonstrate a significant positive impact on concomitant RT for the primary tumour, though only three cases used this treatment. RT was more commonly used after metastasis had occurred.…”

Section: Discussioncontrasting

confidence: 54%

“…One primary tumour was treated with MMS and there was no local recurrence or metastasis of this lesion. Given the infiltrative nature of the tumour and presence of satellite nodules, MMS is likely a promising treatment option and should be considered 12 . Our results did not demonstrate a significant positive impact on concomitant RT for the primary tumour, though only three cases used this treatment.…”

Section: Discussionmentioning

confidence: 52%

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Malignant chondroid syringoma: A systematic review

Zufall

Mark

Gru

2022

Skin Health and Disease

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Malignant Chondroid Syringomas (MCS) are very rare malignant tumours arising from cutaneous sweat glands, with only 51 reported cases in the literature. These tumours can metastasize and cause death if not treated adequately. While there are histological criteria to diagnose MCS tumours, there are no established criterion to determine which tumours are more or less likely to metastasize. A systematic review was performed to establish if any features of the primary MCS tumour are associated with risk of metastasis or patient mortality, as well as the efficacy of common treatment options. The literature search was performed using the Ovid Medline and Web of Science databases from inception through March 2020. This yielded 47 case reports corresponding to 51 unique patients. Statistical analysis of the collected data revealed none of the commonly accepted malignant histopathologic findings (including nuclear atypia and/or pleomorphism, mitotic figures, an infiltrative growth pattern, presence of satellite nodules, necrosis, and vascular and/or perineural invasion) of the primary tumour to be significantly more associated with metastatic risk or death. However, gross characteristics of the tumour, including size (greater than 5 cm) and truncal location of the primary lesion, were found to be associated with a higher risk of metastasis. The most effective treatment modality was wide local excision. Overall, primary MCS tumours, especially those greater than 5 cm or located on the trunk, should be treated with a wide local excision and followed closely to confirm no lesion recurrence or distant metastasis.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 52%

Malignant chondroid syringoma: A systematic review

Zufall

Mark

Gru

2022

Skin Health and Disease

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“…Benign cutaneous mixed tumor occurs most commonly in the head-and-neck region, but other reported sites include the scrotum, eyelid, and brain [3][4][5][6]. The malignant variety most often involves the lower extremities of females [7].…”

Section: Discussionmentioning

confidence: 99%

Benign chondroid syringoma: Report of a case clinically mimicking a malignant neoplasm

2000

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“…2 Unlike CMTs, there is an approximately 2:1 female predominance, and tumors are more common on the extremities. [2][3][4][5][6] Most cases of cutaneous MMT occur in the fifth decade of life, although an age range of 9-92 has been reported. 2 Clinically similar to CMTs, these tumors are typically asymptomatic without overlying cutaneous changes but tend to be larger in size and associated with more rapid growth.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Malignant Mixed Tumor With Pulmonary Metastasis: A Case Report and Literature Review

Haberecht,

Tekin,

Warren

et al. 2024

The American Journal of Dermatopathology

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Background: Cutaneous malignant mixed tumor (MMT) is a rare sweat gland–derived tumor characterized by admixed malignant epithelial cells and chondromyxoid stroma. Approximately 50 cases have been described in the literature. Metastasis, which may occur in more than one-third of cases, is most common in the lung. Methods: We summarized the clinicopathologic features of a patient with cutaneous MMT metastatic to the lungs. A literature review of similar cases was completed using Web of Science, Scopus, and PubMed databases. Results: A woman in her 70s presented with an enlarging mass on her left eyebrow; histopathologic examination showed large islands of atypical cells with increased mitotic activity, admixed with necrosis on a background of fibrotic and chondromyxoid stroma. Multiple lung nodules were identified during follow-up. Examination of a pulmonary core needle biopsy specimen was consistent with metastatic cutaneous MMT. Literature review identified 10 cases published between 1980 and 2017. Most primary tumors were large (≥4 cm). Local recurrence was uncommon, and the lung was the only metastatic site in 5 cases. Histopathologically, metastatic tumors were described as more cellular, with diminished stromal tissue compared with the primary lesion. Conclusion: This is 1 of the 11 reports of cutaneous MMT with metastasis to the lungs found in the English-language literature published after 1980. Of note, most reports were published before 1990, making this case study one of the few contemporary descriptions of cutaneous MMT with pulmonary metastases. We think that the present case report will increase the awareness of this rare tumor.

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Malignant cutaneous mixed tumor

Cited by 12 publications

References 0 publications

Malignant chondroid syringoma: A systematic review

Malignant chondroid syringoma: A systematic review

Benign chondroid syringoma: Report of a case clinically mimicking a malignant neoplasm

Cutaneous Malignant Mixed Tumor With Pulmonary Metastasis: A Case Report and Literature Review

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