Malignant chondroid syringoma. Report of a case with widespread metastasis and review of pertinent literature

Ishimura, Eiji; Iwamoto, Hajime; Kobashi, Yoichiro; Yamabe, Hirohiko; Ichijima, Kunio

doi:10.1002/1097-0142(19831115)52:10<1966::aid-cncr2820521032>3.0.co;2-7

Cited by 81 publications

(39 citation statements)

References 13 publications

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“…Only supportive therapy was continued. 7 In our case, the primary tumor recurred after resection and metastasized during a long clinical course. Liver and kidney metastases were discovered 14 and 15 years after removal of the primary tumor, respectively.…”

Section: Discussionmentioning

confidence: 59%

“…Bone and widespread metastases are less common. 7,17,22 Involvement of the spinal column is extremely rare. Ishimura et al reported a case of a 73-year-old man who died of complications associated with compression of the upper thoracic spinal cord, 13 years after the initial diagnosis of malignant chondroid syringoma in his back.…”

Section: Discussionmentioning

confidence: 99%

“…15 Although most reported cases of chondroid syringoma have been benign, several cases of malignancy have been reported. [1][2][3][7][8][9]11,14,17,18,[20][21][22] Malignant chondroid syringoma is the least common variety of sweat gland carcinoma. 10,22 In contrast to its benign counterpart, the malignant form occurs predominantly in women of any age and is observed more commonly in the trunk and extremities.…”

mentioning

confidence: 99%

“…1,8,16,21 Bone and widespread metastases are less common. 7,17,22 We identified only one other report describing spinal cord compression secondary to the metastasis of a malignant chondroid syringoma, but the definitive diagnosis was made by autopsy. 7 To our knowledge, ours is the first case in the MRI era that was diagnosed, treated, and observed in follow-up studies.…”

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confidence: 99%

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Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

Menéndez¹,

Erice²,

Bas³

et al. 2015

SPI

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The authors describe a case of spinal cord compression due to an epidural metastasis of malignant chondroid syringoma. Chondroid syringoma is a rare mixed tumor of the skin composed of both epithelial and mesenchymal elements. Although most are benign, malignant forms have been reported. Malignant chondroid syringoma may progress very slowly and the metastatic spread occurs late, appearing years after the original diagnosis. There is only one other report of spinal cord compression secondary to metastasis of malignant chondroid syringoma, which was finally diagnosed by microscopic examination of an autopsy specimen. This 63-year-old woman presented with a 4-week history of progressive paraparesis. Admission MRI of the thoracic spine showed an extradural mass arising from the posterior elements and left pedicle of T-9, which caused posterior compression of the spinal cord. Surgical decompression resulted in resolution of the neurological impairments. The histological results were consistent with metastasis of malignant chondroid syringoma. The patient underwent adjuvant radiotherapy and a favorable outcome was noted at the 2-year follow-up visit. This represents the first reported case of spinal cord compression from a metastasis of a malignant chondroid syringoma histologically confirmed in vivo. The authors' experience in this case suggests that resection followed by radiotherapy might be an acceptable means for achieving short-term, progression-free survival.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

Menéndez¹,

Erice²,

Bas³

et al. 2015

SPI

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“…143,[291][292][293][294][295][296][297][298][299][300][301][302] Carcinosarcoma has been reported to arise in a patient with multiple cylindromas. 303 …”

Section: Introductionmentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Recurrent Facial Nodule

Picascia¹

1989

Arch Dermatol

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A 44-year-old man presented with a recurrent asymptomatic solitary facial lesion (Fig 1). One year prior to presentation, the lesion was removed by surgical excision at another institution. It recurred 8 months later and was slowly enlarging. The patient was otherwise in good health. On physical examination, the nodule was firm, nontender, and well circumscribed. It measured 1.4 cm in diameter and was not adherent to the labial mucosa. Results of the rest of the physical examination were normal, including the absence of lymphadenopathy. Results of a laboratory workup, consisting of a complete blood cell count with differential, measurement of serum electrolytes, hepatic and renal profiles, and a chest roentgenogram, were normal.

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Malignant chondroid syringoma. Report of a case with widespread metastasis and review of pertinent literature

Cited by 81 publications

References 13 publications

Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report

Malignant adnexal neoplasms

Recurrent Facial Nodule

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