1982
DOI: 10.1001/archderm.118.7.512
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Malignant angioendotheliomatosis proliferans treated with doxorubicin

Abstract: An 84-year-old man was examined for progressive pain, edema, and infiltrating skin lesions on his lower extremities. A skin biopsy specimen confirmed the suspected diagnosis of angioendotheliomatosis proliferans. The clinical course and histologic changes suggested the malignant form of this disease. Treatment with intravenous doxorubicin hydrochloride caused a complete clinical remission.

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Cited by 11 publications
(15 citation statements)
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“…Intravascular lymphoma (IVL) was described first in 1959 by Pfleger and Tappeiner under the designation 'Angioendotheliomatosis proliferans systemisata'. 1 The disease was for long considered to be a malignant neoplasm of endothelial differentiation [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] but immunohistochemical studies finally revealed the lymphocytic differentiation of the proliferations of atypical cells within vessels. 19,20 Histopathological findings are stereotypical and consist of infiltrates of large blasts within vessels of the superficial and deep plexus in the dermis sometimes also involving vessels in the upper part of the subcutaneous fat ( Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Intravascular lymphoma (IVL) was described first in 1959 by Pfleger and Tappeiner under the designation 'Angioendotheliomatosis proliferans systemisata'. 1 The disease was for long considered to be a malignant neoplasm of endothelial differentiation [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] but immunohistochemical studies finally revealed the lymphocytic differentiation of the proliferations of atypical cells within vessels. 19,20 Histopathological findings are stereotypical and consist of infiltrates of large blasts within vessels of the superficial and deep plexus in the dermis sometimes also involving vessels in the upper part of the subcutaneous fat ( Fig.…”
Section: Discussionmentioning
confidence: 99%
“…15 More recent data suggest that modern combination chemotherapy regimens may improve outcome. Combination chemotherapy with or without radiation has resulted in clinical disease remission, 6,7,15,16,[30][31][32][33][34][35][36] some of which are durable. 8,13,16,37 At last follow-up the patient presented in the current study had been recurrence free for Ͼ 4 years, and hopefully has been cured of her disease.…”
Section: Discussionmentioning
confidence: 99%
“…10 Superficial telangectasias overlying the indurated areas have occasionally been described. 10,11 In our patient, induration was a minor feature while telangectases were marked. Unusual skin findings have included generalized telangectasia, 12 asymptomatic purpuric patches, 13 panniculitis-like lesions with spontaneous regression, 14 and Kaposi sarcoma-like lesions.…”
Section: Discussionmentioning
confidence: 52%
“…17 Including our patient, an additional 15 cases treated with chemotherapy have been reported. 2,10,11,14,[18][19][20][21][22][23][24] In these more recent reports, CHOP was the standard treatment. Eight patients showed complete remission; one woman was disease free seven years after treatment.…”
Section: Discussionmentioning
confidence: 99%