Malignant angioendothelioma

Mehregan, A. H.

doi:10.1001/archderm.112.11.1565

Cited by 6 publications

(7 citation statements)

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“…The tumors were divided into three groups-those that were well differentiated, the less well differentiated, and a poorly differentiated group (in scoring the histologic difnc. 5. Multiple nodules of temple region consisting of h skin colored nodules lacking a vascular appearance.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

Angiosarcoma of the face and scalp, prognosis and treatment

Holden

Spittle

Jones

1987

Cancer

488

353

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72 patients with angiosarcoma (AS) of the face and scalp have been analyzed with respect of various prognostic factors and the effects of different treatment regimes. This disease predominantly occurs in the elderly (age range, 56-92 years), and affects men rather more frequently than women (men: 44, women: 28). The clinical presentation varied, and included bruise-like lesions, dusky plaques, chronic edema or cellulitis, ulcerated nodules, pyoderma, and infected conditions. Due to lack of clinical awareness and problems with histologic assessment, delays in diagnosis were frequent. The majority of the tumors arose in the upper part of the face or scalp. Less commonly, the central part of the face was affected while only three tumors developed in the mandibular region. Overall the prognosis was poor; one half of the patients died within 15 months of presentation. Only 12% of the patients survived 5 years or more. Patients with lesions that were less than 10 cm in diameter responded better to treatment and statistically survived longer than those with larger lesions, emphasizing the crucial importance of early diagnosis. There is some indication that men, younger patients, patients with lesions on the central part of the face survived longer, but this was not of statistical significance. The histologic differentiation of the tumors at presentation also was of doubtful prognostic significance. Despite the overall poor prognosis, radical radiotherapy (mostly wide-field electron-beam therapy) in seven patients resulted in the apparent eradication of the local skin disease and prolonged survival of the patients. Pulmonary metastases developed 10 years later in two of those patients, however, but the face and scalp remained tumor-free.

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Section: Histopathologic Findingsmentioning

confidence: 99%

Angiosarcoma of the face and scalp, prognosis and treatment

Holden

Spittle

Jones

1987

Cancer

488

353

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“…Wide surgical excision is the treatment of choice followed by radiation therapy. 12 These tumors have shown a propensity to metastasize, and long‐term survival (>2 y) is uncommon. Malignant angioendothelioma is distinctly different pathologically from the other dermatological malignancies that can cause purpura: angiosarcoma, lymphangiosarcoma, cutaneous T‐cell lymphoma, and Kaposi's hemorrhagic sarcoma.…”

Section: Discussionmentioning

confidence: 99%

Facial Purpura

et al. 2001

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“…130 This disease has become increasingly more common and noticeable due to its association with acquired immune deficiency syndrome. 131 Other vascular tumors that may appear as purpuric phenomena include hemangiopericytoma, 132 angiosarcoma, 133 angioendothelioma, 134 and proliferating angioendotheliomatosis. 135…”

Section: Purpura Associated With Vascular Malignancymentioning

confidence: 99%

The Purpuric Disorders

Kitchens¹

1984

Semin Thromb Hemost

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Malignant angioendothelioma

Cited by 6 publications

References 0 publications

Angiosarcoma of the face and scalp, prognosis and treatment

Angiosarcoma of the face and scalp, prognosis and treatment

Facial Purpura

The Purpuric Disorders

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