Mali Acroangiodermatitis in Homozygous Activated Protein C Resistance

Scholz, Susanne; Schuller‐Petrovič, Sanja; Kerl, Helmut

doi:10.1001/archderm.141.3.396

Cited by 9 publications

(6 citation statements)

References 4 publications

(4 reference statements)

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“…There are two main clinical variants of AAD—the Mali-type, associated with venous hypertension, and the Stewart-Bluefarb type, associated with arteriovenous malformation (AVM) or acquired arteriovenous fistula (iatrogenic as in patients with chronic renal failure or traumatic). It is also described as being linked with paralysis of the affected limb, congenital myopathy, 4 amputation stumps, 5 the use of poorly fitting suction-type prosthesis, 6 20210A mutation in the prothrombin gene, 7 activated protein c resistance, 8 and syndromes such as the Prader-Labhart-Willi and Klippel-Trenaunay syndrome. 9 A case of idiopathic pseudo–Kaposi sarcoma is recently reported.…”

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confidence: 99%

Pseudo-Kaposi sarcoma worsening after leg vein harvest for coronary artery bypass grafting

Alshihry

Chisti

Hamadah

2014

Annals of Saudi Medicine

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Acroangiodermatitis (AAD) (synonym, pseudo-Kaposi sarcoma) is a term that encompasses 2 different conditions: (1) AAD of Mali, which refers to skin lesions that mainly develop bilaterally on the lower extremities of patients with chronic venous insufficiency and is an extreme form of stasis dermatitis and (2) Stewart–Bluefarb syndrome, which consists of an arteriovenous malformation that mainly affects the limbs of young patients unilaterally. We present a case of a 68-year-old lady with progressive skin lesions on both lower limbs (right > left) as a result of chronic venous insufficiency that became worse after the leg-vein harvest for coronary artery bypass grafting was taken from the right leg. Up to our knowledge this is the first case of its kind to be reported.

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confidence: 99%

Pseudo-Kaposi sarcoma worsening after leg vein harvest for coronary artery bypass grafting

Alshihry

Chisti

Hamadah

2014

Annals of Saudi Medicine

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“…The histological features include capillary proliferations and perivascular inflammation characterized by eosinophils in the dermis with minimal epidermal pathology. 9 The patch stage of Kaposi’s sarcoma is characterized by perivascular infiltrate of plasma cells and lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

A Case of Patch Stage of Kaposi's Sarcoma and Discussion of the Differential Diagnosis

et al. 2016

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A 55 year old HIV positive male had a skin lesion biopsy which showed atypical vascular proliferation within the superficial and deep dermis with mild atypia of lining endothelial cells. A sparse lymphoplasmacytic infiltrate surrounding the irregular vascular channels was noted. Immunohistochemistry highlighted the atypical blood vessels with the vascular markers CD31, CD34 and Factor VIII. The differential diagnosis included unusual vascular or lymphatic proliferations, stasis dermatitis, kaposiform hemangioendothelioma, progressive lymphangioma and angiosarcoma with focal Kaposi’s sarcoma features. Characteristic human herpes virus-8 positive staining helped support the diagnosis of patch stage of Kaposi’s sarcoma. Herein, we discuss the case findings, differential diagnosis and characteristic histological findings associated with the patch stage of Kaposi’s sarcoma which can be an elusive diagnosis.

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“…Acroangiodermatitis may be associated with chronic venous insufficiency, thrombophilic disorders, stump dermatosis in amputees, and with some vascular abnormalities such as Klippel–Trenaunay syndrome, or arteriovenous malformations . Impairment in the venous flow and a disturbed vascular innervation has been hypothesized playing a possible role in its development …”

Section: Discussionmentioning

confidence: 99%