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Cited by 373 publications
(78 citation statements)
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References 96 publications
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“…The higher affinity of DHT in association with enhanced activity of the enzyme 5α-reductase leads to the development of DHT-dependent structures, i.e. prostate, prostatic utricle, scrotum, penis with male-type urethra and the glans penis [2, 3, 4, 5, 6]. …”
Section: Introductionmentioning
confidence: 99%
“…The higher affinity of DHT in association with enhanced activity of the enzyme 5α-reductase leads to the development of DHT-dependent structures, i.e. prostate, prostatic utricle, scrotum, penis with male-type urethra and the glans penis [2, 3, 4, 5, 6]. …”
Section: Introductionmentioning
confidence: 99%
“…From studies of inherited 5␣-reductase-deficient patients, investigators have concluded that T is able to stimulate psychosexual behavior and the development of Wolffian duct, muscle, voice deepening, spermatogenesis, and axillary as well as pubic hair growth (7,8). DHT seems to be necessary for the development of prostate and external genitalia, the male pattern hair growth, and male-form baldness (9). From 5␣-reductase insufficiency and the complete form of testicular feminization, in which no trace of androgen function is detected due to a nonfunctional androgen receptor (AR) gene mutation (10), it has been generally accepted that only one AR is responsible for both T and DHT stimulation.…”
mentioning
confidence: 99%
“…At birth, these individuals have ambiguous external genitalia, indicating the important role for DHT in male sexual development (6,7). At puberty, when plasma levels of T increase, virilization of these individuals occurs.…”
mentioning
confidence: 99%