Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis

Trüeb, Ralph M.; Meyer, J

doi:10.1159/000018368

Cited by 16 publications

(5 citation statements)

References 9 publications

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“…We concluded that an increased conversion of testosterone to 17β‐oestradiol, and andros‐ tendione to oestrone, takes place in hair follicles derived from the occiput under the influence of estradiol. In theory, this pathway may diminish the amount of intrafollicular testosterone available for conversion to DHT 39 …”

Section: Aromatasementioning

confidence: 99%

Male androgenetic alopecia

Hoffmann

2002

Clinical and Experimental Dermatology

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Androgenetic alopecia (AGA) is the most common type of hair loss in men. The relative strong concordance of the degree of baldness in fathers and sons is not consistent with a smiple Mendelian trait and a polygenic basis is considered to be most likely. So far the predisposing genes for AGA are unknown and we do not understand the molecular steps involved in androgen-dependent beard growth versus androgen-dependent hair loss, but AGA can be defined as a DHT-dependent process with continuous miniaturization of sensitive hair follicles. The type 2 5aR plays a central role by the intrafollicular conversion of T to DHT. Due to the inceasing knowledge in this field, this article shall privide an critical overwiew of recent discoveries.

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Section: Aromatasementioning

confidence: 99%

Male androgenetic alopecia

Hoffmann

2002

Clinical and Experimental Dermatology

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“…22 We conducted a survey of patients with XRI showing that this is not the case, since these men also showed advanced PHL. 23 …”

Section: Role Of Sexual Hormonesmentioning

confidence: 99%

Understanding Pattern Hair Loss—Hair Biology Impacted by Genes, Androgens, Prostaglandins and Epigenetic Factors

Trüeb¹

2021

Indian J Plast Surg

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Pattern hair loss (PHL) is the most frequent cause of hair loss in men and women, accounting for 65% of consultations in a hair referral center. PHL is understood to represent a hereditary, age-dependent progressive thinning of the scalp hair, which follows distinct clinical patterns with notable differences depending on sex and age of onset. Clinical and investigative advances have helped us to understand some of the pathogenic steps, leading to PHL. Besides genetic factors and peculiarities of androgen metabolism, additional pathogenic factors that are suspected include microbiomata, oxidative stress, and microinflammation. While further suspects are likely to be exposed, individual diversity of causal agents, as well as of the sequence of events, or combined factors, must be kept in mind. A large number of therapeutic molecules claimed to be active and patented in this field, and their limited efficacy in offering a definitive cure of PHL confirm the complexity of PHL. The aim of therapy is to retard progression of hair thinning and increase hair coverage of the scalp. As yet, two FDA-approved drugs are available for this purpose, oral finasteride, and topical solution of minoxidil. Variations in posology and formulation allow for an enhancement of patient comfort and treatment efficacy. Antiandrogen treatments in women with normal androgen levels have questionable efficacy while having health risks.

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“…Andere systematische Untersuchungen legen nahe,dass der Insulin-like Growth Factor (IGF-1) und das Insulin-like Growth Factor Binding Protein-(ILGBP-)3 als mögliche Faktoren bei der AGA-Entstehung eine Rolle spielen [64,78]. Eine Untersuchung auf molekularer Ebene steht für IGF-1 noch aus, obwohl wir wissen, dass das Insulingen [22] und auch das Gen der Steroidsulfatase [30,87] und das "hairless-Gen" [81] nicht für die Erblichkeit der AGA verantwortlich sind. Ein Fallbericht [49] diskutiert die Bedeutung des für die Adrenoleukodystrophie verantwortlichen Genes (PTS1 receptor gene,PXR1; 600414) oder des Peroxin-1-Gens (PEX1; 602136), da Adrenoleukodystrophiepatienten eine erheblich stärkere AGA aufweisen als die Normalbevölkerung.…”

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Androgenetische Alopezie

Hoffmann¹

2004

Der Hautarzt

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Androgenetic alopecia is the most common form of hair loss in men and women. Although the clinical manifestations are different in men and women, the pathogenetic pathways leading to this type of hair loss are similar in both sexes. In short genetically predestined hair follicles show an increased sensitivity to androgens. In recent years, much new data concerning the pathophysiology, management and therapy of androgenetic alopecia has been gathered. This article gives a critical overview of these new findings and assesses their practical relevance.

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Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis

Cited by 16 publications

References 9 publications

Male androgenetic alopecia

Male androgenetic alopecia

Understanding Pattern Hair Loss—Hair Biology Impacted by Genes, Androgens, Prostaglandins and Epigenetic Factors

Androgenetische Alopezie

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