Male fertility: Genome integrity and sperm DNA methylation

Abstract

Male infertility is a complex multifactorial pathology that correlates in some extent with semen parameters including sperm counts, motility, morphology, viability and nucleus integrity. The large debate surrounding global decline of semen parameters motivated numerous studies dealing with this important issue. The present article reviews different factors shown to impact on male fertility by affecting semen parameters, namely, epigenetics and sperm genome integrity.To cite this article: Debbie Montjean, et al. Male fertility: Genome integrity and sperm DNA methylation. Stem Cell Epigenet 2016; 3: e1106.