Male factor infertility and ART

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

“…In conjunction with this are reports that indicate a significant decrease in the quality of human semen [2][3][4] . It is estimated that male-related disorders are probably present in up to 40% to 50% of childless couples, alone or in combination with female factors [5,6] . Environmental chemical contaminants, including pesticides such as organophosphates (OP) insecticides have been largely implicated in this reproductive deficit [7] .…”

Overcoming male factor infertility with intracytoplasmic sperm injection

“…16 Overall, the use of ICSI has not been shown to cause any more negative effects than those seen with IVF. 9,17 ICSI actually enhances normal fertilization rate, since the requirement for cumulus cells removal allowed a better visualization of oocytes structure and maturity, and led to a better oocyte selection. 18 Moreover, spermatozoa selection made ICSI the preferred line of treatment regardless of the infertility cause.…”

The Next Frontier: The Promise of in vitro Spermatogenesis Coupled with Intracytoplasmic Sperm Injection

“…Now, two decades and over 10,000 births since that initial publication, ICSI is commonly used in fertility clinics in cases when the quantity or quality of spermatozoa are too low to generate embryos through traditional in vitro fertilization (IVF). While many questions linger as to the long-term outcome of ICSI from a genetic and epigenetic perspective, thus far no measurable abnormalities in offspring conceived by this technique have been observed [2]. Now just one spermatozoon is required for reproductive success.…”