Male circumcision for prevention of homosexual acquisition of HIV in men

Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China

“…A meta-analysis of 20 observational studies with 65,784 participants showed a weaker, also marginally significant association (OR, 0.86; 95% CI, 0.70-1.06). 6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1).…”

“…6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1). Chinese MSM do not have risk indices quite as high as in other MSM populations; the magnitude of risk in other populations could conceivably overwhelm the biological protective effects of circumcision.…”

Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China

“…A meta-analysis of 20 observational studies with 65,784 participants showed a weaker, also marginally significant association (OR, 0.86; 95% CI, 0.70-1.06). 6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1).…”

“…6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1). Chinese MSM do not have risk indices quite as high as in other MSM populations; the magnitude of risk in other populations could conceivably overwhelm the biological protective effects of circumcision.…”

Anal Sex Role Segregation and Versatility Among Men Who Have Sex With Men

“…However, in the same review, circumcision was found to significantly reduce HIV acquisition by 73% among circumcised MSM who reported exclusively or predominantly insertive anal sex roles. 30 Given that male circumcision is likely to be effective in preventing HIV infection only among MSM who are mainly insertive, 30,31 our finding that merely 16.7% were exclusively insertive during UAS over 30 months suggests that promoting male circumcision may be of limited value as an HIV prevention strategy for MSM in the U.S.…”

Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review

“…The limited assessment of circumcision status and sex positioning may lead to misclassification that would tend to under/overestimate VMMC benefits. 11,14 When misclassification bias is eliminated by conducting direct penile examination as well as by including detailed sexual position data, promise in VMMC as a tool to reduce HIV risk among MSM than previously assumed. 14 Third, the nature of cross-sectional study designs may limit the inference of the association between VMMC and HIV.…”

Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China

“…A meta-analysis of 20 observational studies with 65,784 participants showed a weaker, also marginally significant association (OR, 0.86; 95% CI, 0.70-1.06). 6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1).…”

“…6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1). Chinese MSM do not have risk indices quite as high as in other MSM populations; the magnitude of risk in other populations could conceivably overwhelm the biological protective effects of circumcision.…”

Anal Sex Role Segregation and Versatility Among Men Who Have Sex With Men

“…However, in the same review, circumcision was found to significantly reduce HIV acquisition by 73% among circumcised MSM who reported exclusively or predominantly insertive anal sex roles. 30 Given that male circumcision is likely to be effective in preventing HIV infection only among MSM who are mainly insertive, 30,31 our finding that merely 16.7% were exclusively insertive during UAS over 30 months suggests that promoting male circumcision may be of limited value as an HIV prevention strategy for MSM in the U.S.…”

Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review

“…The limited assessment of circumcision status and sex positioning may lead to misclassification that would tend to under/overestimate VMMC benefits. 11,14 When misclassification bias is eliminated by conducting direct penile examination as well as by including detailed sexual position data, promise in VMMC as a tool to reduce HIV risk among MSM than previously assumed. 14 Third, the nature of cross-sectional study designs may limit the inference of the association between VMMC and HIV.…”

Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China

“…A meta-analysis of 20 observational studies with 65,784 participants showed a weaker, also marginally significant association (OR, 0.86; 95% CI, 0.70-1.06). 6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1).…”

“…6 As expected, the protective odds were strongest among circumcised MSM who practiced insertive anal sex, 31 which is consistent with the finding from that meta-analysis (OR, 0.27; 95% CI, 0.17-0.44). 6 The stronger association in our population of uncircumcised status and higher HIV odds may be partially explained by our objective assessment of male circumcision status through genital examination, which eliminated misclassification in our study (Table 1). Chinese MSM do not have risk indices quite as high as in other MSM populations; the magnitude of risk in other populations could conceivably overwhelm the biological protective effects of circumcision.…”

Anal Sex Role Segregation and Versatility Among Men Who Have Sex With Men

“…However, in the same review, circumcision was found to significantly reduce HIV acquisition by 73% among circumcised MSM who reported exclusively or predominantly insertive anal sex roles. 30 Given that male circumcision is likely to be effective in preventing HIV infection only among MSM who are mainly insertive, 30,31 our finding that merely 16.7% were exclusively insertive during UAS over 30 months suggests that promoting male circumcision may be of limited value as an HIV prevention strategy for MSM in the U.S.…”

Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review

“…The limited assessment of circumcision status and sex positioning may lead to misclassification that would tend to under/overestimate VMMC benefits. 11,14 When misclassification bias is eliminated by conducting direct penile examination as well as by including detailed sexual position data, promise in VMMC as a tool to reduce HIV risk among MSM than previously assumed. 14 Third, the nature of cross-sectional study designs may limit the inference of the association between VMMC and HIV.…”