Malaria in Sub-Saharan Africa

Evaluation of Blood Smears, Quantitative Buffy Coat and Rapid Diagnostic Tests in the Diagnosis of Malaria

“…Malaria is a well-known disease and it continues to be a major public health problem at the start of new millennium. Reliable diagnosis of malaria requires laboratory confirmation of the presence of malaria parasites in the blood of a febrile patient [7]. Although microscopic examination of blood smear continues to be the gold standard, it has a drawback that it is time consuming and requires an expert microscopist and less sensitive in cases of low parasitemia [8].…”

Evaluation of Blood Smears, Quantitative Buffy Coat and Rapid Diagnostic Tests in the Diagnosis of Malaria

“…Malaria is a well-known disease and it continues to be a major public health problem at the start of new millennium. Reliable diagnosis of malaria requires laboratory confirmation of the presence of malaria parasites in the blood of a febrile patient [7]. Although microscopic examination of blood smear continues to be the gold standard, it has a drawback that it is time consuming and requires an expert microscopist and less sensitive in cases of low parasitemia [8].…”

Nanomedicines in the pediatric therapy: Tribulation and road ahead

“…Malaria is the parasite illness that causes the most morbidity and mortality worldwide [53]. In 2011, nearly 3.3 billion people contracted malaria, with 80% of cases and 90% of fatalities occurring in Sub-Saharan Africa [54]. The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers.…”

“…The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers. Malaria can be prevented and cured, but it resulted in the death of more than 6 million children in 2010 [54], which comprised 20% of the paediatric deaths in Africa [55]. Artemisinin-based combination treatments (ACTs) are the first-line therapy for simple falciparum malaria in children, which come in difficult-to-swallow tablets [56].…”

Comparison of five methods of malaria detection in the outpatient setting.

“…In eastern Africa, where 90% of the malaria is due to Plasmodium falciparum, accuracy of malaria diagnosis at the outpatient level is becoming increasingly important due to emerging drug resistance and the use of alternative, costly antimalarial drugs. 4 Laboratory confirmation of malaria infection requires the availability of a rapid, sensitive, and specific test at an affordable cost. Conventional methods of laboratory diagnosis for malaria use microscopic examination of stained thick blood films.…”

Evaluation of Blood Smears, Quantitative Buffy Coat and Rapid Diagnostic Tests in the Diagnosis of Malaria

“…Malaria is a well-known disease and it continues to be a major public health problem at the start of new millennium. Reliable diagnosis of malaria requires laboratory confirmation of the presence of malaria parasites in the blood of a febrile patient [7]. Although microscopic examination of blood smear continues to be the gold standard, it has a drawback that it is time consuming and requires an expert microscopist and less sensitive in cases of low parasitemia [8].…”

Nanomedicines in the pediatric therapy: Tribulation and road ahead

“…Malaria is the parasite illness that causes the most morbidity and mortality worldwide [53]. In 2011, nearly 3.3 billion people contracted malaria, with 80% of cases and 90% of fatalities occurring in Sub-Saharan Africa [54]. The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers.…”

“…The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers. Malaria can be prevented and cured, but it resulted in the death of more than 6 million children in 2010 [54], which comprised 20% of the paediatric deaths in Africa [55]. Artemisinin-based combination treatments (ACTs) are the first-line therapy for simple falciparum malaria in children, which come in difficult-to-swallow tablets [56].…”

Comparison of five methods of malaria detection in the outpatient setting.

“…In eastern Africa, where 90% of the malaria is due to Plasmodium falciparum, accuracy of malaria diagnosis at the outpatient level is becoming increasingly important due to emerging drug resistance and the use of alternative, costly antimalarial drugs. 4 Laboratory confirmation of malaria infection requires the availability of a rapid, sensitive, and specific test at an affordable cost. Conventional methods of laboratory diagnosis for malaria use microscopic examination of stained thick blood films.…”

Evaluation of Blood Smears, Quantitative Buffy Coat and Rapid Diagnostic Tests in the Diagnosis of Malaria

“…Malaria is a well-known disease and it continues to be a major public health problem at the start of new millennium. Reliable diagnosis of malaria requires laboratory confirmation of the presence of malaria parasites in the blood of a febrile patient [7]. Although microscopic examination of blood smear continues to be the gold standard, it has a drawback that it is time consuming and requires an expert microscopist and less sensitive in cases of low parasitemia [8].…”

Nanomedicines in the pediatric therapy: Tribulation and road ahead

“…Malaria is the parasite illness that causes the most morbidity and mortality worldwide [53]. In 2011, nearly 3.3 billion people contracted malaria, with 80% of cases and 90% of fatalities occurring in Sub-Saharan Africa [54]. The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers.…”

“…The most severely affected subpopulations are children under the age of 5 years, as well as pregnant mothers. Malaria can be prevented and cured, but it resulted in the death of more than 6 million children in 2010 [54], which comprised 20% of the paediatric deaths in Africa [55]. Artemisinin-based combination treatments (ACTs) are the first-line therapy for simple falciparum malaria in children, which come in difficult-to-swallow tablets [56].…”

Comparison of five methods of malaria detection in the outpatient setting.

“…In eastern Africa, where 90% of the malaria is due to Plasmodium falciparum, accuracy of malaria diagnosis at the outpatient level is becoming increasingly important due to emerging drug resistance and the use of alternative, costly antimalarial drugs. 4 Laboratory confirmation of malaria infection requires the availability of a rapid, sensitive, and specific test at an affordable cost. Conventional methods of laboratory diagnosis for malaria use microscopic examination of stained thick blood films.…”