Malaria in a holoendemic area of Burkina Faso: a cross-sectional study

Stich, August; Oster, Nadja; Abdel-Aziz, Inas Z.; Stieglbauer, Gabriele; Coulibaly, Boubacar; Wickert, Hannes; McLean, Jeremy E.; Kouyaté, Bocar; Becher, Heiko; Lanzer, Michael

doi:10.1007/s00436-005-0104-9

Cited by 9 publications

(14 citation statements)

References 17 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2007, when transmission was highest, several well established risk factors correlated with infection, including younger age [23], presence of anaemia [24], using open water sources [4], sleeping without a bed net [3-5,8], rainy season [5,7], and self-reported or documented symptoms [2]. However, in 2008 and 2009, when the prevalence of malaria was substantially lower, only self-reported or documented fever correlated with infection.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous prior studies identified individual-level risk factors for malaria, but many were conducted in areas of high endemicity [2] and among high-risk groups, such as children [3-5] and pregnant women [6,7]. However, in regions with declining malaria transmission as a result of accelerated control efforts, these well-characterized, individual-level risk factors for malaria may not be valid [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study

Sutcliffe

Tamaki

Hamapumbu

et al. 2011

Malar J

View full text Add to dashboard Cite

BackgroundMalaria elimination will require that both symptomatic- and asymptomatic-infected persons be identified and treated. However, well-characterized, individual-level risk factors for malaria may not be valid in regions with declining malaria transmission. Changes in individual-level correlates of malaria infection were evaluated over three years in a region of declining malaria transmission in southern Zambia.MethodsMalaria surveys were conducted in two study areas within the catchment area of Macha Hospital, Zambia in 2007 and 2008/2009. A random sample of households was identified from a digitized satellite image of the study areas. Cross-sectional surveys were conducted approximately five times throughout the year in each of the two study areas. During study visits, adults and caretakers of children were administered questionnaires and a blood sample was obtained for a rapid diagnostic test (RDT) for malaria.ResultsIn the 2007 study area, 330 individuals were surveyed. 40.9% of participants lived in a household with at least one insecticide-treated bed net (ITN); however, only 45.2% reported sleeping under the ITN. 23.9% of participants were RDT positive. Correlates of RDT positivity included younger age, the presence of symptoms, testing during the rainy season, using an open water source, and not sleeping under an ITN. In the 2008 study area, 435 individuals were surveyed. 77.0% of participants lived in a household with at least one ITN; however, only 56.4% reported sleeping under the ITN. 8.1% of participants were RDT positive. RDT positivity was negatively correlated with the presence of symptoms within the last two weeks but positively correlated with documented fever. In 2009, 716 individuals were surveyed in the same area as 2008. 63.7% of participants lived in a household with at least one ITN; however, only 57.7% reported sleeping under the ITN. 1.5% of participants were RDT positive. Only self-reported fever was significantly correlated with RDT positivity.ConclusionsWith declining malaria prevalence, few individual-level characteristics were correlated with RDT positivity. This lack of correlation with individual characteristics hampers identification of individuals infected with malaria. Strategies based on ecological or environmental risk factors may be needed to target control efforts and achieve further reductions and elimination.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study

Sutcliffe

Tamaki

Hamapumbu

et al. 2011

Malar J

View full text Add to dashboard Cite

show abstract

“…Malaria is a frequent cause of clinically apparent anemia in Nouna and infection with Plasmodium species is highly prevalent after the rainy season (approximately 80% as detected by microscopic examination of thick blood films and more than 90% by PCR techniques) [12]. The persistence of submicroscopic Plasmodium gametocyte carriage which has been shown to be common in an area of low and seasonal transmission [13] may lead to increased hemolysis and clearance of uninfected erythrocytes and have also have a negative impact on hematopoesis [14].…”

Section: Resultsmentioning

confidence: 99%

Gender-Specific Distribution of Hematological Parameters in Adults Living in Nouna, Burkina Faso

Böhler

Kynast‐Wolf²,

Coulibaly³

et al. 2008

TOHJ

View full text Add to dashboard Cite

show abstract

“…The complete details of the protocol of each study have been described elsewhere (17, 18, 26–28) and shorter summaries are presented here. Briefly, the ITN study was a randomized controlled trial to assess the long-term effects of ITN protection during early infancy among 3,387 children from 41 villages in CRSN (27).…”

Section: Methodsmentioning

confidence: 99%

“…The Environment and Weather Malaria (EWM) study was an observational study among 867 children to determine the prevalence of malaria among the cohort children, the incidence of malaria, and the effect of temperature, rainfall, and relative humidity on Plasmodium falciparum infection risk (18). The Bourasso study was a cross-sectional study to evaluate the prevalence of malaria infections, chloroquine related resistance, and proportion of moderate to severe anemia in all residents of Bourasso village (including 355 children) near Nouna, Burkina Faso (28).…”

Section: Methodsmentioning

confidence: 99%

Decreasing childhood mortality and increasing proportion of malaria deaths in rural Burkina Faso

Ramroth

Ndugwa

Müller

et al. 2009

Global Health Action

Self Cite

View full text Add to dashboard Cite

BackgroundMalaria is the leading cause of death among children less than five years of age in sub-Saharan Africa (SSA), however, precise estimates on the burden of malaria are lacking. The aim of this study was to describe temporal trends for malaria and all-cause mortality by combining a series of clinical and intervention studies conducted in Burkina Faso.MethodsData from a demographic surveillance system was used to follow-up children under five years who participated in five observational and intervention studies between June 1999 and December 2004 in rural north-western Burkina Faso. Mortality data was analyzed with cause-specific mortality ascertained using the verbal autopsy method. Person-years (PY) of observations were computed and age-standardized mortality rates (MR) for all-causes and malaria (adjusted for missing causes of death) were calculated. Rate ratios to investigate mortality variations over years were calculated using multivariate Poisson regression.ResultsThe study followed 6,387 children aged less than five years (mean follow-up: 2.8 years; 16,099 PY). During the study period, 443 deaths were registered with malaria accounting for 49% of all deaths. All-cause and malaria-specific MR were 26.7 (95% CI: 24.2–29.2) and 15.8 (95% CI: 14.217.7) per 1,000 PY. All-cause MR declined over years of follow-up (from 31.2 to 16.3 per 1,000 PY in 1999/2000 to 2004, respectively) but malaria MR remained relatively stable (from 15.8 to 12.1 per 1,000 PY in 1999/2000 to 2004, respectively) resulting in an increasing relative effect of malaria on all-cause mortality. Variations in all-cause and malaria-specific mortality were observed with increasing age and across village town clusters.ConclusionThe findings of this study support the continuously decreasing trend of all-cause mortality in most of SSA, but call for more efforts to comprehensively address malaria with existing control tools such as insecticide-treated bed nets and effective first-line combination therapies.

show abstract

Malaria in a holoendemic area of Burkina Faso: a cross-sectional study

Cited by 9 publications

References 17 publications

Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study

Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study

Gender-Specific Distribution of Hematological Parameters in Adults Living in Nouna, Burkina Faso

Decreasing childhood mortality and increasing proportion of malaria deaths in rural Burkina Faso

Contact Info

Product

Resources

About