2018
DOI: 10.1002/jlb.3ri1018-400r
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Abstract: Invasive bacterial disease is well described in immunocompromised hosts, including those with malaria infection. One bacterial infection frequently observed in children with Plasmodium falciparum infection is nontyphoidal salmonella (NTS) infection, in which a typically intestinal infection becomes systemic with serious, often fatal, consequences. In this review, we consider the role of malaria‐induced immunoregulatory responses in tipping the balance from tissue h… Show more

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Cited by 35 publications
(36 citation statements)
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References 121 publications
(202 reference statements)
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“…Bacterial super-infection is well described in acute malaria, and low-density asymptomatic malaria infections are a risk factor for non-typhi salmonella bacteraemia in children [56] and young adults in Burkina Faso [57]. Salmonella typhimurium during malaria may facilitate bacterial colonization [58], and experimental studies in animals indicate shifts in enteric microbiota and increase in susceptibility to intestinal colonization by S. typhimurium [59]. In vivo evidence indicates that S. typhimurium benefits from iron availability during malaria infection [60].…”
Section: Resultsmentioning
confidence: 99%
“…Bacterial super-infection is well described in acute malaria, and low-density asymptomatic malaria infections are a risk factor for non-typhi salmonella bacteraemia in children [56] and young adults in Burkina Faso [57]. Salmonella typhimurium during malaria may facilitate bacterial colonization [58], and experimental studies in animals indicate shifts in enteric microbiota and increase in susceptibility to intestinal colonization by S. typhimurium [59]. In vivo evidence indicates that S. typhimurium benefits from iron availability during malaria infection [60].…”
Section: Resultsmentioning
confidence: 99%
“…It has been postulated that Plasmodium -induced immune suppression and susceptibility to invasive bacterial infections is not attributed to a parasite-specific factor. Rather, it is due to Plasmodium -induced hemolysis, and subsequent activation of HO-1 and IL-10 that inhibit neutrophil functions lead to weakened immune responses to invasive bacterial infections (Mooney et al, 2019 ). Yet, we demonstrate that Py-induced immune suppression lasts up to 2-months post clearance of Py infected RBCs, when the effects of hemolysis are likely no longer in play.…”
Section: Discussionmentioning
confidence: 99%
“…A combination of an impaired immune system and tissue damage increases the chance of a severe complication (38,39). Diminished innate immune function can cause uncontrolled bacterial growth and lead to pneumonia or death (40). Current therapies for T2DM focus on lowering blood glucose, insulin sensitization and weight loss.…”
Section: Discussionmentioning
confidence: 99%