Malakoplakia of the Omentum and Endometrium

Koetsawang, Amorn; Senapad, S; Boriboonhiransarn, Dittakarn; Robertson, Donald Ian

doi:10.1111/j.1447-0756.1992.tb00307.x

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…In conclusion, the diagnosis of malacoplakia is based on a combination of clinical presentation; imaging studies, such as ultrasound; and histological examination of affected tissues. Endometrial malacoplakia typically presents with postmenopausal bleeding, abnormal uterine bleeding in menstruating women, or a suspicious uterine mass [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Our case is the first of malacoplakia presenting with abundant vaginal sero-hematic secretions months after surgery for a cesarean section.…”

Section: Table 1: Summary Of the Previous Cases Reported In Literatur...mentioning

confidence: 99%

“…This is likely due to defective lysosomal function, leading to the formation of von Hansemann cells, a characteristic histological finding in malakoplakia [3][4][5][6][7][8][9][10][11][12][13][14]. Involvement of the female genital tract is rare, with less than 40 cases reported to date, of which only 15 cases of endometrium malacoplakia [4][5][6][7][8][9][10][11][12][13][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Tracking Endometrial Malacoplakia Through the Evolution of 2D and 3D Ultrasound and Histopathological Features

Vimercati,

Cirignaco,

De Nola

et al. 2024

Cureus

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Malacoplakia is an uncommon disease characterized by chronic and granulomatous inflammation, which rarely involves the female genital tract. We describe the ecographic and histological evolution of the first case of a patient developing endometrial malacoplakia as a complication after a cesarean section. The patient, a 43-year-old woman, presented with pelvic pain one month after delivering by cesarean section and the initial suspicion was of retention of placental rests. We discuss the diagnostic challenges for this rare disease, highlighting the importance of considering endometrial malacoplakia as a possible diagnosis in patients with similar clinical presentations and the important role of 2D and 3D ultrasound in the diagnostic pathway. In literature, ultrasound findings in cases of endometrial malacoplakia are represented by hypoechoic thickening of the endometrial lining; hyperechoic thickening of the myometrium, and the presence of masses, nodules, cystic areas, or anechoic fluid within the endometrium. For the first time, we describe the evolution of endometrial malacoplakia through both ultrasound, 2D and 3D, and histopathological findings, from the acute to chronic stage of the disease.

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Section: Table 1: Summary Of the Previous Cases Reported In Literatur...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tracking Endometrial Malacoplakia Through the Evolution of 2D and 3D Ultrasound and Histopathological Features

Vimercati,

Cirignaco,

De Nola

et al. 2024

Cureus

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Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Voort

Velden²,

Wassenaar³

et al. 1996

Archives of Internal Medicine

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Malacoplakia is a rare infectious disease that has been almost exclusi vely reported in urology and pathology journals. We studied two cases of malacoplakia that were primarily referred to the department of internal medicine because of fever and abdominal masses. In one patient, malacoplakia was diagnosed in the unusual ovarian location, while in the other patient a large renal mass was found and ciprofloxacin therapy failed because of bacterial resistance. The clinical and radiologic appearance of malacoplakia often mimics that of a malignant tumor. The principal disorder is probably a monocytic-macrophagic bactericidal defect. A definitive diagnosis depends on microscopic detection of Michaelis-Gutmann bodies by means of von Kossa stain. We outlined treatment strategies on the basis of a review of the literature since 1981, which included 140 cases. If possible, immunosuppressive drugs should be stopped. Quinolone antibiotic treatment and surgical excision or incision and drainage lead to the highest cure rates (90% and 81%, respectively). Specific intracellular penetration of quinolone antibiotics is a possible reason for the higher cure rate achieved with these antibiotics. Bethanechol has been suggested to correct the supposed fundamental disturbance by increasing the intrecellular cyclic guanosine monophosphate concentration, but there is still no convincing evidence of its clinical efficacy.

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Malakoplakia of the Endometrium: A Rare Unexpected Disease Raising Clinical Concern for Malignancy

Fischer,

Jones,

et al. 2024

Int J Surg Pathol

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Malakoplakia is a rare disease that manifests as a histiocytic inflammatory process and most often occurs in the urinary bladder. It is caused by an impaired capacity of histiocytes to kill and digest bacteria. The typical histopathologic findings are sheets of histiocytes with granular eosinophilic cytoplasm and characteristic Michaelis–Gutmann bodies, spherical bodies with a targetoid appearance. Malakoplakia is even rarer in the gynecologic tract, and our literature search found only 21 published patients of malakoplakia involving the endometrium. Here we report a 60-year-old female patient who presented with recurrent pelvic infections and postmenopausal bleeding, which raised concern for an endometrial malignancy. Hysterectomy with salpingo-oophorectomy revealed malakoplakia involving the endometrium and also the right ovary. Michaelis–Gutmann bodies were visible on the intraoperative frozen section that was performed to rule out an endometrial malignancy. We summarize the clinicopathologic findings of the published patients of endometrial malakoplakia.

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Malakoplakia of the Omentum and Endometrium

Abstract: A rare case of malakoplakia involving the omentum and endometrium is presented. This is the first documented case of malakoplakia in the Thai population.

Cited by 4 publications

References 9 publications

Tracking Endometrial Malacoplakia Through the Evolution of 2D and 3D Ultrasound and Histopathological Features

Tracking Endometrial Malacoplakia Through the Evolution of 2D and 3D Ultrasound and Histopathological Features

Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review

Malakoplakia of the Endometrium: A Rare Unexpected Disease Raising Clinical Concern for Malignancy

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