Makroporöse Styrol-Divinylbenzol-Copolymere und ihre Verwendung in der Chromatographie und zur Darstellung von Ionenaustauschern

Seidl, Josef; Malinský, J.; Dušek, Karel; Heitz, Walter

doi:10.1007/bfb0051281

Cited by 320 publications

(126 citation statements)

References 77 publications

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“…6 In this process, the porous matrices may be obtained by using diluents as extensively Polymer beads are widely used as carrier matrices studied for polystyrene, polymethymethacrylate, in various medical and biological applications, and polyacrylamide. [7][8][9][10][11][12][13][14] The type and concentrasuch as drug delivery systems, scintigraphic imtion of diluent in the monomer phase and the exaging, affinity chromatograpy, enzyme immobilitent of crosslinking control the porosity of the mization, and cell culturing.…”

Section: Introductionmentioning

confidence: 99%

Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads

Şenel

Çiçek

Tuncel

1998

J. Appl. Polym. Sci.

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Nonswellable and swellable poly(ethyleneglycol dimethacrylate)-based microbeads that could react directly with the biological molecules were produced by a suspension polymerization procedure. For this purpose, ethyleneglycol dimethacrylate (EGDMA) was copolymerized with glycidyl methacrylate (GMA) in an aqueous suspension medium. Benzoyl peroxide and poly(vinyl alcohol) were used as the initiator and the stabilizer, respectively. The copolymerization provided nonswellable, tranparent, and spherical copolymer microbeads in the size range of 100-300 mm. On the other hand, swellable copolymer microbeads in the aqueous medium were obtained by using toluene as a diluent in the same copolymerization recipe. In a separate group of polymerizations, styrene (St) monomer was also included within the monomer phase to regulate the hydrophobicity of resulting microbeads. Nonswellable and swellable poly-(EGDMA-St-GMA) microbeads were obtained by changing the type and concentration of the ingredients within the monomer phase. The effects of glycidyl methacrylate, styrene, and toluene concentrations on the microbead yield, the average size, and the swellability of microbeads were investigated. In the second part of the study, the interaction of produced microbeads with a selected enzyme (i.e., chymotrypsin) was investigated. The most stable chymotrypsin immobilization was achieved with the swellable poly(EGDMA)-based microbeads including styrene.

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Section: Introductionmentioning

confidence: 99%

Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads

Şenel

Çiçek

Tuncel

1998

J. Appl. Polym. Sci.

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“…1,4 The phase separation takes place at a lower monomer conversion for systems with a high fraction of crosslinker. Both the absorption of monomers in the nuclei and the coalescence of the nuclei are limited as a result of their crosslinking.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Porous structures are typically formed during the copolymerization of mixtures containing a divinyl monomer and inert porogens. [1][2][3][4] Polymer beads are usually produced by suspension polymerization in which stirring provides some control of the average size of the droplets and the resulting beads. 5 This technique affords beads with a broad particle size distribution.…”

Section: Introductionmentioning

confidence: 99%

Characterization of crosslinked, macroporous, monosized polymer particles

Nyhus¹,

Hagen²,

Berge³

2000

J. Appl. Polym. Sci.

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Macroporous, monosized poly(meta-divinylbenzene) and poly(para-divinylbenzene) beads have been prepared by the two-step activated swelling method with toluene or 2-ethylhexanoic acid as pore-forming agents. The type of divinylbenzene isomer as well as the type of porogen has a large effect on both physical and chemical properties of the monodisperse beads. Large pores are obtained with 2-ethylhexanoic acid as porogen while beads prepared in the presence of toluene consist of only small pores and exhibit a shrinking behavior upon drying. The beads have considerable amounts of residual vinyl groups at the end of polymerization, as determined by bromination and Fourier transform IR analysis. The morphology and texture of the particles have been investigated by scanning electron microscopy and atomic force microscopy.

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“…The term macroporous copolymers designate materials prepared in the presence of a pore-forming agent (inert component, porogen), having a permanent well-developed porous structure even in the dry state (Seidl et al, 1967). As proposed by Kun and Kunin (1968), the beads present agglomerate of microspheres (100-200 nm).…”

Section: Supportsmentioning

confidence: 99%

Immobilization of biocatalysts for enzymatic polymerizations: Possibilities, advantages, applications

Miletić¹,

Nastasović

Loos

2012

Bioresource Technology

182

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a b s t r a c tBiotechnology also holds tremendous opportunities for realizing functional polymeric materials. Biocatalytic pathways to polymeric materials are an emerging research area with not only enormous scientific and technological promise, but also a tremendous impact on environmental issues. Many of the enzymatic polymerizations reported proceed in organic solvents. However, enzymes mostly show none of their profound characteristics in organic solvents and can easily denature under industrial conditions. Therefore, natural enzymes seldom have the features adequate to be used as industrial catalysts in organic synthesis. The productivity of enzymatic processes is often low due to substrate and/or product inhibition. An important route to improving enzyme performance in non-natural environments is to immobilize them.In this review we will first summarize some of the most prominent examples of enzymatic polymerizations and will subsequently review the most important immobilization routes that are used for the immobilization of biocatalysts relevant to the field of enzymatic polymerizations.

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Makroporöse Styrol-Divinylbenzol-Copolymere und ihre Verwendung in der Chromatographie und zur Darstellung von Ionenaustauschern

Cited by 320 publications

References 77 publications

Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads

Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads

Characterization of crosslinked, macroporous, monosized polymer particles

Immobilization of biocatalysts for enzymatic polymerizations: Possibilities, advantages, applications

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