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Cited by 6 publications
(7 citation statements)
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“…Current understanding on a role of VSELs/OSCs resulting in neo-oogenesis and follicular assembly was recently reviewed [ 119 , 120 ]. We have reported similar findings in the testis including that testicular niche (Sertoli cells) gets compromised after chemotherapy and transplanting mesenchymal cells restores spermatogenesis [ 26 , 55 ].…”
Section: Making Oocytes In a Dishmentioning
confidence: 74%
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“…Current understanding on a role of VSELs/OSCs resulting in neo-oogenesis and follicular assembly was recently reviewed [ 119 , 120 ]. We have reported similar findings in the testis including that testicular niche (Sertoli cells) gets compromised after chemotherapy and transplanting mesenchymal cells restores spermatogenesis [ 26 , 55 ].…”
Section: Making Oocytes In a Dishmentioning
confidence: 74%
“…However, as the initial cells were not purified, it was possible that few mature stem/germ cells including SSCs existed in the initial cultures that could have differentiated into sperm. The approaches of in vitro differentiation of mouse VSELs by our group [ 54 ] and mES cells by Zhou et al [ 44 ] were compared and discussed [ 55 ].…”
Section: Making Sperm In a Dishmentioning
confidence: 99%
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“…We have recently reported that even mouse bone marrow VSELs can differentiate into germ cells in vitro 22 . Choosing between ES/iPS/VSELs to make gametes has been debated 23 24 .…”
Section: Making Gametes From Hes and Ips Cells Versus Vselsmentioning
confidence: 99%
“…The complexity of the systemic and testicular microenvironment makes it difficult to study SSCs in vivo; SSCs may thus be well studied in an in vitro microenvironment where the investigator can carefully regulate the composition of the microenvironment.The establshment of stable human SSCs in vitro would create a useful stem cell model for studying the proliferation and differentiation of SSCs [Liu et al 2011]. Recently very small embryoniclike stem cells (VSELs) have been identified in the testis, which are more primitive stem cells that can give rise to SSCs in vitro [Bhartiya et al 2016].…”
Section: Introductionmentioning
confidence: 99%