Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

“…In contrast, others have shown that rapamycin reduces LPL gene expression and activity in the retroperitoneal adipose tissue of rats treated with the drug (Blanchard et al, 2012;Houde et al, 2010). Important differences between the present study and the previous ones include duration of treatment and the species studied.…”

Lipoprotein lipase: From gene to atherosclerosis

“…PPARs and retinoic acid receptor (RXR) can form a PPAR-RXR heterodimer so as to bind to the PPRE in the LPL promoter and up-regulates the expression of LPL in a tissuespecific manner [54]. PPARg predominantly influences adipocyte differentiation and lipid storage [55,56]. PPARa and PPARd are closely associated with lipid accumulation in hepatocytes and macrophages [57].…”

A comparative perspective on lipid storage in animals

“…2). The increase in adiposity found upon high-fat feeding, leptin deficiency or pharmacological PPARc activation is associated with a marked activation of mTORC1 in adipose tissue (Um et al, 2004;Blanchard et al, 2012). Furthermore, pharmacological or genetic inhibition of mTORC1 is associated with a reduction in adipose tissue mass due to both reduced adipocyte size and number (Polak et al, 2008;Houde et al, 2010).…”