Major Depression in Chinese Medicine Outpatients with Stagnation Syndrome: Prevalence and the Impairments in Well‐Being

Ng, Siu-Man; Leng, Ling-Li

doi:10.1155/2018/7234101

Cited by 4 publications

(7 citation statements)

References 36 publications

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“…Western drugs effectively manage PDD but are associated with side effects and decreased quality of life [ 13 – 15 ]. TCM can be combined with western drugs for depressive disorders [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Medication is still the primary treatment method [ 1 , 11 , 12 ]. Traditional Chinese medicine (TCM) can also be used to manage PDD [ 13 – 15 ]. Both TCM and western medicine have certain curative effects, but each has advantages and disadvantages [ 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) can also be used to manage PDD [ 13 – 15 ]. Both TCM and western medicine have certain curative effects, but each has advantages and disadvantages [ 13 , 16 ]. Simple western medication has stable and lasting effects.…”

Section: Introductionmentioning

confidence: 99%

“…However, many patients can hardly persist or stop taking drugs due to the strong side effects. Although TCM's side effects are milder than western medicine, the effect onset is slow, and the effect cannot be stable and lasting [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial

Gong

et al. 2022

Contrast Media & Molecular Imaging

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Background. Western drugs effectively manage persistent depressive disorder (PDD) but are associated with side effects. Objective. To observe the efficacy and safety of modified Xiaochaihu Decoction combined with mirtazapine in treating PDD. Methods. Patients with PDD were enrolled at the Naval General Hospital (06/2018–02/2019) and randomized to modified Xiaochaihu Decoction and modified Xiaochaihu Decoction with mirtazapine. The self-rating depression scale (SDS) and traditional Chinese medicine (TCM) scale were assessed at baseline and after 12 weeks. The overall clinical efficacy (primary outcome) and adverse reactions were observed. Results. Sixty-four participants completed the trial in the combined and control groups (30 and 28), respectively. In controls, the total effective rate was 78.6%, compared with 96.7% in the combined group ( P = 0.035 ). The scores of the SDS and TCM syndrome scale in the two groups were lower after treatment ( P < 0.001 ) but without difference between groups ( P = 0.077 ). The combined group showed higher improvement rates regarding insomnia (96.4% vs. 44.0%, P < 0.001 ), bitter taste (90.5% vs. 52.6%, P = 0.007 ), languid (72.0% vs. 31.8%, P = 0.006 ), and belching/anorexia (100% vs. 52.6%, P < 0.001 ). The combined group showed a higher frequency of adverse events (73.3% vs. 3.6%) ( P < 0.001 ). Conclusion. Modified Xiaochaihu Decoction combined with mirtazapine effectively treats PDD, and its curative effect is better than that of TCM alone. Trial Registration. This trial was registered with https://www.chictr.org.cn/index.aspx/ChiCTR2100048188.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial

Gong

et al. 2022

Contrast Media & Molecular Imaging

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“…Stagnation Syndrome includes depression, restlessness, emotional changes, lack of energy, frequent sighing, and poor appetite (97,98). Leng et al (99,100) suggested that Stagnation Syndrome was related to MDD and functional somatic syndrome, because Stagnation Syndrome showed various bodily symptoms and psychological problems.…”

Section: Necessity For New Anger Disordermentioning

confidence: 99%

How Suppressed Anger Can Become an Illness: A Qualitative Systematic Review of the Experiences and Perspectives of Hwabyung Patients in Korea

et al. 2021

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Background: In the clinical field, anger has generally been studied in terms of aggressive behavior. However, in Asians, anger suppression is more common than anger expression. Hwabyung is a culture-related anger syndrome in Korea and is known to occur due to the continued repression of anger. Investigating Hwabyung should lead to a better understanding of the multiple dimensions of anger. To explore Hwabyung patients' experiences and perspectives, a meta-aggregation approach was used to conduct a systematic review and a qualitative synthesis.Methods: A systematic search was conducted in MEDLINE/PubMed, EMBASE, Allied and Complementary Medicine Database (AMED), Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycARTICLES, and four Korean databases [Korean Medical Database (KMbase), Korean Studies Information Service System (KISS), National Digital Science Library (NDSL), and Oriental Medicine Advanced Searching Integrated System (OASIS)] in September 2020. Studies were included if they collected and analyzed qualitative data from Hwabyung patients. Qualitative research findings on the experiences and perspectives of Hwabyung patients in Korea were critically appraised and synthesized using the Joanna Briggs Institute methodology.Results: Seven eligible studies were included. The findings from those studies (i.e., theme or subtheme of qualitative research) were aggregated into categories (a group of similar findings) and synthesized findings (a group of categorized findings). Ultimately, 116 findings were aggregated into 15 categories. Finally, four synthesized findings were derived from the 15 categories: (i) anger arousal, (ii) blame, (iii) uncontrollable physical and emotional symptoms, and (iv) compromise and temporary coping.Conclusions: Patients with Hwabyung experience chronic anger through the complex cognitive processes involved in blame. Hwabyung negatively affects patients' physical, psychological, and social functions. Because Hwabyung patients feel as if they are losing control, due to emotional dysregulation and physical symptoms, professional support should be provided to facilitate their coping strategies. Further studies on Hwabyung can serve as a new model of pathological anger.

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A multicenter registry of neuropsychiatric outpatients in Korean medicine hospitals (KMental): Protocol of a prospective, multicenter, registry study

Suh

Moon

et al. 2022

Medicine

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Introduction: Mental health is an important global health concern. In Korea, many people visit Korean medicine clinics due to Stagnation syndrome and Hwabyung (cultural idioms of distress). Methods and analysis:We established a research collaboration comprising of professionals from 8 Korean medicine hospitals and planned a prospective, multicenter registry study. Demographic, socioeconomic, and clinical data will be collected from patients with mental disorders visiting the Korean medicine neuropsychiatric department of Korean medicine hospitals. We will include major psychiatric diagnoses related to neurosis and Korean traditional mental disorders such as Stagnation syndrome and Hwabyung.We expect to identify comprehensive characteristics of participants, measure the severity of their symptoms or distress, and investigate patterns of Korean medicine interventions and treatment responses for both the short-term and long-term (at least 4 years). Additionally, this study will include Health Insurance Review & Assessment Service data to analyze the medical use of registered patients before and after registration, in case the participant submits the consent form for personal information collection and use.To analyze the effectiveness of Korean medicine treatment for the participants, stratified or corrected analyses of age, sex, and diagnosis will be performed. The difference in the change in the psychometric measurements, quality of life measured by short form 36, and quality-adjusted life years will be calculated to evaluate the effectiveness of Korean medicine treatment.Abbreviations: AE = adverse events, CAM = complementary and alternative medicine, CM = concomitant drugs, DSM = diagnostic and statistical manual of mental disorders, IRB = institutional review board, KSCL95 = Korean version of the checklist-90-revised, MDD = major depressive disorder, SCL-90-R = checklist-90-revised, SF-36 = short form 36, STAI = state-trait anxiety inventory, STAXI = state-trait anger expression inventory.

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Major Depression in Chinese Medicine Outpatients with Stagnation Syndrome: Prevalence and the Impairments in Well‐Being

Cited by 4 publications

References 36 publications

Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial

Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial

How Suppressed Anger Can Become an Illness: A Qualitative Systematic Review of the Experiences and Perspectives of Hwabyung Patients in Korea

A multicenter registry of neuropsychiatric outpatients in Korean medicine hospitals (KMental): Protocol of a prospective, multicenter, registry study

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