Major Birth Defects at King Fahd Hofuf Hospital: Prevalence, Risk Factors and Outcome

Refat, Mamdouh; Al-Moghanem, Mohamed; McDonald, P.; Reyes, Lourdes Narcio

doi:10.5144/0256-4947.1995.339

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…However this increased frequency of congenital anomalies in infants of GDM mothers is in concordance with studies conducted by many other researchers 15 .…”

Section: Discussionsupporting

confidence: 81%

“…Even though our data showed a steady increase in the frequency of anomalies in women with higher parity, the association was not signifi cant. In contrast to our fi ndings, both advanced maternal age and increasing parity have been implicated in other studies with higher occurrences of birth defects, and this is especially signifi cant in the Arab region where women continue child-bearing until menopause 6,8,15 . A Case-Control study in Saudi Arabia of 30,159 live born infants, found mothers of neonates with chromosomal malformations, were older and of greater parity than control groups 15 .…”

Section: Discussioncontrasting

confidence: 56%

“…The percentage of low (≤ 2.4kg) and high (≥ 4.0kg) birth weights were Congenital Anomalies at Birth: A Hospital Based Study in UAE similar at 5.5% (67) and 5.6% (68) respectively, and again majority of births 88.9% (1079) fell in the normal birth weight range (2.5 -3.9kg). One minute APGAR scores were generally normal (≥ 7) in over 98.8% (1198) of the population and less than 1.2% (15) showing scores 6 or less.…”

Section: Resultsmentioning

confidence: 99%

“…This association can be explained in terms of the conditions that predispose an infant to be born with a high birth weight. Large for Gestation Age and Macrosomic infants are regularly seen in multiparous women or those with GDM; and these maternal variables have a proven association with increased rates of congenital anomalies 15 . There are also several well recognized types of congenital anomalies that are seen in infants with high birth weight: genetic syndromes such as Beckwith Wiedemann and Perlman syndromes, hip subluxation, talipes, brachial plexus injuries 24 , certain cardiac and CNS defects and omphalocele 25 .…”

Section: Discussionmentioning

confidence: 99%

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Congenital Anomalies at Birth: A Hospital Based Study in UAE

Aryasinghe

Moezzi

et al. 2012

J. Nepal Paedtr. Soc.

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“…However this increased frequency of congenital anomalies in infants of GDM mothers is in concordance with studies conducted by many other researchers 15 .…”

Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Congenital Anomalies at Birth: A Hospital Based Study in UAE

Aryasinghe

Moezzi

et al. 2012

J. Nepal Paedtr. Soc.

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“…This rate is higher than that reported in studies from many high-income countries, as those reported by EUROCAT (261/10 000 births),11 British Isles Network of Congenital Anomaly Registers (BINOCAR) (206/10 000 births)12 and the Bradford study (305/10 000) 13. This prevalence of CAs is also higher than that previously reported from Saudi Arabia (115 to 257 per 10 000 live births) 14–16. Although some studies report an even higher prevalence, for example, such as an antenatal CA prevalence of 521/10 000 pregnancies screened, and a prevalence among live births of 465/10 000,17 these figures may be overestimates of the true prevalence because of the inclusion of mothers referred from other institutions.…”

Section: Discussionmentioning

confidence: 58%

Congenital anomalies and associated risk factors in a Saudi population: a cohort study from pregnancy to age 2 years

et al. 2019

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ObjectiveTo assess the three key issues for congenital anomalies (CAs) prevention and care, namely, CA prevalence, risk factor prevalence and survival, in a longitudinal cohort in Riyadh, Saudi Arabia.SettingTertiary care centre, Riyadh, Saudi Arabia.ParticipantsSaudi women enrolled during pregnancy over 3 years and their 28 646 eligible pregnancy outcomes (births, stillbirths and elective terminations of pregnancy for foetal anomalies). The nested case-control study evaluated the CA risk factor profile of the underlying cohort. All CA cases (1179) and unaffected controls (1262) were followed through age 2 years. Referred mothers because of foetal anomaly and mothers who delivered outside the study centre and their pregnancy outcome were excluded.Primary outcome measuresPrevalence and pattern of major CAs, frequency of CA-related risk factors and survival through age 2 years.ResultsThe birth prevalence of CAs was 412/10 000 births (95% CI 388.6 to 434.9), driven mainly by congenital heart disease (148 per 10 000) (95% CI 134 to 162), renal malformations (113, 95% CI 110 to 125), neural tube defects (19, 95% CI 25.3 to 38.3) and chromosomal anomalies (27, 95% CI 21 to 33). In this study, the burden of potentially modifiable risk factors included high rates of diabetes (7.3%, OR 1.98, 95% CI 1.04 to 2.12), maternal age >40 years (7.0%, OR 2.1, 95% CI 1.35 to 3.3), consanguinity (54.5%, OR 1.5, 95% CI 1.28 to 1.81). The mortality for live births with CAs at 2 years of age was 15.8%.ConclusionsThis study documented specific opportunities to improve primary prevention and care. Specifically, folic acid fortification (the neural tube defect prevalence was >3 times that theoretically achievable by optimal fortification), preconception diabetes screening and consanguinity-related counselling could have significant and broad health benefits in this cohort and arguably in the larger Saudi population.

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Individualized medicine enabled by genomics in Saudi Arabia

et al. 2015

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The biomedical research sector in Saudi Arabia has recently received special attention from the government, which is currently supporting research aimed at improving the understanding and treatment of common diseases afflicting Saudi Arabian society. To build capacity for research and training, a number of centres of excellence were established in different areas of the country. Among these, is the Centre of Excellence in Genomic Medicine Research (CEGMR) at King Abdulaziz University, Jeddah, with its internationally ranked and highly productive team performing translational research in the area of individualized medicine. Here, we present a panorama of the recent trends in different areas of biomedical research in Saudi Arabia drawing from our vision of where genomics will have maximal impact in the Kingdom of Saudi Arabia. We describe advances in a number of research areas including; congenital malformations, infertility, consanguinity and pre-implantation genetic diagnosis, cancer and genomic classifications in Saudi Arabia, epigenetic explanations of idiopathic disease, and pharmacogenomics and personalized medicine. We conclude that CEGMR will continue to play a pivotal role in advances in the field of genomics and research in this area is facing a number of challenges including generating high quality control data from Saudi population and policies for using these data need to comply with the international set up.

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Major Birth Defects at King Fahd Hofuf Hospital: Prevalence, Risk Factors and Outcome

Cited by 4 publications

References 14 publications

Congenital Anomalies at Birth: A Hospital Based Study in UAE

Congenital Anomalies at Birth: A Hospital Based Study in UAE

Congenital anomalies and associated risk factors in a Saudi population: a cohort study from pregnancy to age 2 years

Individualized medicine enabled by genomics in Saudi Arabia

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