Magnetofluorescent Fe3O4/carbon quantum dots coated single-walled carbon nanotubes as dual-modal targeted imaging and chemo/photodynamic/photothermal triple-modal therapeutic agents

Zhang, Ming; Wang, Wentao; Cui, Yaya; Chu, Xiaohong; Sun, Baohong; Zhou, Ninglin; Shen, Jian

doi:10.1016/j.cej.2018.01.081

Cited by 117 publications

(49 citation statements)

References 40 publications

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“…Figure 1C displays an HRTEM image of the sectional hybrid nanoparticles. As shown in Figure 1C, HRTEM image of Fe 3 O 4 @CDs nanocomposite with the lattice spacing around 0.343 nm, corresponding to the (220) plane of the Fe 3 O 4 (Zhang et al, 2018), and the lattice spacing around 0.211 nm, agreeing well with the crystallographic (002) spacing of carbon (Justin et al, 2016). The results show that the CDs are successfully loaded on the surface of Fe 3 O 4 .…”

Section: Synthesis and Characterization Of Fe 3 O 4 @Cdssupporting

confidence: 73%

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Kuang

Zhang

Xiong

et al. 2020

Front. Bioeng. Biotechnol.

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Alzheimer’s disease (AD) is the most common neurodegenerative disease, which seriously affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are considered a possible target for AD treatment. Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Aβ-mediated neurotoxicity by inhibiting Aβ aggregation. However, the efficiency of targeted cellular uptake and bioavailability of CUR is very low due to its poor stability and water-solubility. In order to better improve the cell uptake efficiency and bioavailability of CUR and reduce the cytotoxicity of high-dose CUR, a novel CUR delivery system for AD therapy has been constructed based on the employment of the Fe3O4@carbon dots nanocomposite (Fe3O4@CDs) as the carrier. CUR-Fe3O4@CDs have a strong affinity toward Aβ and effectively inhibit extracellular Aβ fibrillation. In addition, CUR-Fe3O4@CDs can inhibit the production of reactive oxygen species (ROS) mediated by Aβ fibrils and the corresponding neurotoxicity in PC12 cells. More importantly, it can restore nerve damage and maintained neuronal morphology. These results indicate that the application of CUR-Fe3O4@CDs provides a promising platform for the treatment of AD.

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Section: Synthesis and Characterization Of Fe 3 O 4 @Cdssupporting

confidence: 73%

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Kuang

Zhang

Xiong

et al. 2020

Front. Bioeng. Biotechnol.

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“…81 The CQDs have also been used for drug delivery in other researches, including passivated CQDs with polyaminecontaining organosilane molecules for delivery of DOX, 105 organophilic CQDs for anticancer drug curcumin delivery with high loading efficiency and rapid penetration into the HeLa cells, 178 CQDs synthesized through hydrothermal treatment of pasteurized milk for delivery of lisinopril (Lis) to HeLa cells, 179 CQDs/calcium alginate hydrogel lm for delivery of glycopeptides antibiotic vancomycin in the gastrointestinal tract, 180 CQDs/mesoporous silica nanocarriers for delivery of DOX, 181 functionalized and surface passivated CQDs for delivery of DOX to the MCF-7 cells, 182 and CQDs/hydroxyapatite hybrid nanorods for delivery of DOX to the HeLa cells and human prostatic cancer (PC-3) cells. 183 The CQDs have been used in multifunctional platforms for drug delivery and magnetic delivery and/or MRI agents and/or simultaneous co-delivery of two or more drugs, including multi-functional DDS of CQDs and DOX and heparin as an auxiliary medicine for delivery to the A549 cells, Fe 3 O 4 @CQDs coated single-walled carbon nanotubes loaded with DOX and conjugated with an sgc8c aptamer as a platform for combining cancer photothermal therapy, chemotherapy, and photodynamic therapy, 185 and magnetic gadolinium oxide-iron oxide core, mesoporous silica shell gated with boronic acid functionalized CQDs for drug delivery of anticancer drug 5-uorouracil to HePG2 cancer cells which the platform acts as MRI agent and optical imaging agent as well as stimuli-responsive DDS. 186…”

Section: Drug Deliverymentioning

confidence: 99%

Carbon quantum dots and their biomedical and therapeutic applications: a review

2019

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“…To prove that DDNPs also have higher targeting specificity and binding stability than do single or non-targeted NPs in vivo and can significantly improve the imaging effect of mixed thrombus under high shear force in vivo, it is necessary to select a suitable imaging modality for visualization research. In addition, the visualization of the delivery and distribution of NPs could play a guiding role in disease therapy 43–45. However, one of the greatest conundrums of selection is that modalities with the highest sensitivity have relatively poor resolution, while those with high resolution have relatively poor sensitivity 46.…”

Section: Resultsmentioning

confidence: 99%

<p>Polydopamine-modified dual-ligand nanoparticles as highly effective and targeted magnetic resonance/photoacoustic dual-modality thrombus imaging agents</p>

Zhong¹,

Ye²,

Xu³

et al. 2019

IJN

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Background Platelet activation and subsequent aggregation are the initial stages of thrombosis. A molecular probe that specifically targets activated platelets and remains retained under high shear stress in vivo can enhance the imaging effect to achieve early and accurate diagnosis. Methods and materials In this study, we constructed nanoparticles (NPs) using polydopamine to carry two peptides that simultaneously bind integrin αIIbβ3 and P-selectin on activated platelets to enhance the targeting of NPs to thrombus. Results The targeting specificity and binding stability of the NPs on red and white thrombi were demonstrated in vitro using a simulated circulatory device and the targeting effect of the NPs on mixed thrombus was studied by magnetic resonance (MR)/photoacoustic (PA) dual-modality imaging in vivo. NPs that were surface modified with both peptides have higher selectivity and retention to red and white thrombi in vitro than NPs with a single or no peptide, and the targeting effect was closely related to the number and distribution of activated platelets as well as the structure and type of thrombus. The NPs also have MR/PA dual-modality imaging functionality, significantly enhancing the imaging of mixed thrombus in vivo. Conclusion These dual-targeted NPs have improved targeting specificity and binding stability to different thrombi under high shear stress and are beneficial for the early diagnosis of thrombosis.

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Magnetofluorescent Fe3O4/carbon quantum dots coated single-walled carbon nanotubes as dual-modal targeted imaging and chemo/photodynamic/photothermal triple-modal therapeutic agents

Cited by 117 publications

References 40 publications

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

A Novel Nanosystem Realizing Curcumin Delivery Based on Fe3O4@Carbon Dots Nanocomposite for Alzheimer’s Disease Therapy

Carbon quantum dots and their biomedical and therapeutic applications: a review

<p>Polydopamine-modified dual-ligand nanoparticles as highly effective and targeted magnetic resonance/photoacoustic dual-modality thrombus imaging agents</p>

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