Magnetisation transfer measurements of the subcortical grey and white matter in Parkinson's disease with and without dementia and in progressive supranuclear palsy

Hanyu, Haruo; Asano, Teita; Sakurai, Hirofumi; Takasaki, M; Shindo, Hiroaki; Abe, Kimihiko

doi:10.1007/s002340100558

Cited by 39 publications

(23 citation statements)

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“…27–32,63 These include diseases in the neurodegenerative spectrum, disorders of myelination and inflammation and mood and psychotic disorders. 26,28,29,31–33,63 In these disorders, lower MTR has been demonstrated in neocortical, subcortical and limbic regions, and include gray and white matter architecture.…”

Section: Discussionmentioning

confidence: 99%

Subcortical biophysical abnormalities in patients with mood disorders

et al. 2013

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Cortical–subcortical circuits have been implicated in the pathophysiology of mood disorders. Structural and biochemical abnormalities have been identified in patients diagnosed with mood disorders using magnetic resonance imaging-related approaches. In this study, we used magnetization transfer (MT), an innovative magnetic resonance approach, to study biophysical changes in both gray and white matter regions in cortical–subcortical circuits implicated in emotional regulation and behavior. Our study samples comprised 28 patients clinically diagnosed with major depressive disorder (MDD) and 31 non-depressed subjects of comparable age and gender. MT ratio (MTR), representing the biophysical integrity of macromolecular proteins within key components of cortical–subcortical circuits—the caudate, thalamic, striatal, orbitofrontal, anterior cingulate and dorsolateral regions—was the primary outcome measure. In our study, the MTR in the head of the right caudate nucleus was significantly lower in the MDD group when compared with the comparison group. MTR values showed an inverse relationship with age in both groups, with more widespread relationships observed in the MDD group. These data indicate that focal biophysical abnormalities in the caudate nucleus may be central to the pathophysiology of depression and critical to the cortical–subcortical abnormalities that underlie mood disorders. Depression may also accentuate age-related changes in the biophysical properties of cortical and subcortical regions. These observations have broad implications for the neuronal circuitry underlying mood disorders across the lifespan.

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Section: Discussionmentioning

confidence: 99%

Subcortical biophysical abnormalities in patients with mood disorders

et al. 2013

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“…In one study, no difference in MTR of the subcortical GM and WM has been found between patients with idiopathic PD and matched controls, whereas patients with PD and dementia had significantly lower MTR in the subcortical WM, including frontal WM and the genu of the corpus callosum, and those with progressive supranuclear palsy had significantly lower MTR in the subcortical GM, including the putamen, globus pallidus and thalamus. 152 In another study, lower MTR values in supratentorial WM and brainstem were found in PD patients without dementia, compared with controls. 153 Eckert et al 154 demonstrated changes in the MTR values in the globus pallidus, putamen, caudate nucleus, substantia nigra, and WM in idiopathic PD, in multiple system atrophy, and in progressive supranuclear palsy, matching the pathological features of the underlying disorder.…”

Section: Parkinson's Disease (Pd) and Allied Conditionsmentioning

confidence: 91%

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

Filippi

Rocca

2007

Neurotherapeutics

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Summary:Magnetic resonance imaging is highly sensitive in revealing CNS abnormalities associated with several neurological conditions, but lacks specificity for their pathological substrates. In addition, MRI does not allow evaluation of the presence and extent of damage in regions that appear normal on conventional MRI sequences and that postmortem studies have shown to be affected by pathology. Quantitative MR-based techniques with increased pathological specificity to the heterogeneous substrates of CNS pathology have the potential to overcome such limitations. Among these techniques, one of the most extensively used for the assessment of CNS disorders is magnetization transfer MRI (MT-MRI). The application of this technique for the assessment of damage in macroscopic lesions, in normal-appearing white and gray matter, and in the spinal cord and optic nerve of patients with several neurological conditions is providing important in vivo information-dramatically improving our understanding of the factors associated with the appearance of clinical symptoms and the accumulation of irreversible disability. MT-MRI also has the potential to contribute to the diagnostic evaluation of several neurological conditions and to improve our ability to monitor treatment efficacy in experimental trials.

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“…By using MTI in patients with neurodegenerative parkinsonian disorders, abnormalities of the basal ganglia and substantia nigra were reported in patients with Parkinson's disease, MSA and PSP [60,61,62 ]. The most recent of these studies investigated the potential of MTI in the differential diagnosis of neurodegenerative parkinsonism including 37 patients with different parkinsonian syndromes and 20 age-matched controls [62 ].…”

Section: Magnetization Transfer Imagingmentioning

confidence: 97%

An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism

Seppi¹,

Schocke

2005

Current Opinion in Neurology

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Research findings suggest that novel MRI techniques such as MTI, DWI and MRV have superior sensitivity compared to conventional MRI in detecting abnormal features in neurodegenerative parkinsonian disorders. Whether these techniques will emerge as standard investigations in the work-up of patients presenting with parkinsonism requires further prospective magnetic resonance studies during early disease stages.

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Magnetisation transfer measurements of the subcortical grey and white matter in Parkinson's disease with and without dementia and in progressive supranuclear palsy

Cited by 39 publications

References 0 publications

Subcortical biophysical abnormalities in patients with mood disorders

Subcortical biophysical abnormalities in patients with mood disorders

Magnetization Transfer Magnetic Resonance Imaging of the Brain, Spinal Cord, and Optic Nerve

An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism

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