Magnetically Engineered Semiconductor Quantum Dots as Multimodal Imaging Probes

Jing, Lihong; Ding, Ke; Kershaw, Stephen V.; Kempson, Ivan M.; Rogach, Andrey L.; Gao, Mingyuan

doi:10.1002/adma.201402296

Cited by 150 publications

(144 citation statements)

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“…Synthesis of Magnetic Core/Silica Shell/Plasmonic Nanoparticles Silica is a common choice for coating the magnetic nanoparticles as it is biocompatible, can be functionalised with a variety of surface functional groups and aids internalisation of the nanoparticles into cells [10]. Silica can act as in important mediator layer between an inner magnetic core (e.g., Fe 3 O 4 ) and an outer plasmonic layer (e.g., gold)-the silica allows the seeding of small gold nanoparticles onto its surface, thus allowing for the further reduction of a gold layer, negating the difficulty of reducing gold directly onto magnetite which is difficult due to the mismatch between the crystal lattices of the two materials [11].…”

Section: Coprecipitation Techniquesmentioning

confidence: 99%

“…An external magnetic field and targeted functionalisation can be used to deliver the multimodal magnetic nanocomposites to the desired area, to hold them there until the diagnostic or treatment is complete and to eradicate them at the end. Importantly, all of these steps and processes can be monitored by MRI, CT (computed tomography) and other imaging techniques potentially allowing full control over the medical procedures [10][11][12]. New multimodal magnetic nanostructures have also found applications in molecular-imaging [13,14], as PET-MRI (positron emission tomography-magnetic resonance imaging) contrast agents [15], thermal therapy [16,17] targeted drug delivery and many others [18].…”

Section: Introductionmentioning

confidence: 99%

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Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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Magnetic plasmonic nanomaterials are of great interest in the field of biomedicine due to their vast number of potential applications, for example, in molecular imaging, photothermal therapy, magnetic hyperthermia and as drug delivery vehicles. The multimodal nature of these nanoparticles means that they are potentially ideal theranostic agents-i.e., they can be used both as therapeutic and diagnostic tools. This review details progress in the field of magnetic-plasmonic nanomaterials over the past ten years, focusing on significant developments that have been made and outlining the future work that still needs to be done in this fast emerging area. The review describes the main synthetic approaches to each type of magnetic plasmonic nanomaterial and the potential biomedical applications of these hybrid nanomaterials.

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Section: Coprecipitation Techniquesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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“…Quantum dots are luminescent semiconducting nanocrystals whose emission wavelength is intimately to their size, that is, they can be fabricated with different sizes emitting in different spectral regions. 44 Quantum dots show broad absorption spectra, narrow and size-tuneable emission peaks and large Stokes shifts. These features make quantum dots perfect donors in fluorescence resonance energy transfer (FRET).…”

Section: Fluorescent Nanosensorsmentioning

confidence: 99%

“…[41][42][43] Semiconducting nanoparticles show size-dependent emission properties that cover the whole visible spectrum. 44,45 Nanomaterials have been a true game changer in the field of solution-based sensing due to their easy functionalization, chemical reactivity and outstanding physical properties.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25] A key factor for the development of complex sensing approaches is that these nanomaterials can be decorated with myriads of biomolecules, [26][27][28] nanoparticles show size-dependent emission properties that cover the whole visible spectrum. 44,45 Nanomaterials have been a true game changer in the field of solution-based sensing due to their easy functionalization, chemical reactivity and outstanding physical properties. In this manuscript we will review different solution-based strategies for the naked-eye detection of analytes with nanomaterials.…”

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confidence: 99%

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Solution-based nanosensors for in-field detection with the naked eye

Paterson

Rica

2015

Analyst

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This version is available at https://strathprints.strath.ac.uk/52490/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output.Journal Name Nanomaterials are revolutionising analytical applications with low-cost tests that enable detecting a target molecule in a few steps and with the naked eye. With this approach, nonexperts can perform analyses on-site and without utilising electronic readers. This is advantageous in point-of-care diagnostics, in-field measurements and analyses performed in resource-constrained settings. Here we review the main strategies adopted for detecting analytes with the naked eye and at the point of need using plasmonic nanosensors, catalytic nanoparticles and fluorescent nanomaterials. Examples of the detection of ions, glucose, small molecules, peptides and proteins with the nanosensors are explained in detail. IntroductionThe design of sensors for in-field measurements has been a central issue of analytical chemistry for decades. From the diagnosis of diseases at the point of care 1 to the detection of hazardous levels of pollutants 2,3 and the identification of pathogens in food samples, 4,5 there is a growing need for obtaining accurate information about the composition of a sample rapidly and at the point of need. For many years electrochemical sensors have dominated the area of in-field sensing due to the possibility of fabricating all the elements of the sensor with well-known microfabrication techniques. 6,7 These fabrication methods generate portable, compact devices in which the transducers are directly integrated with the circuitry. 8,9 However, although microchips containing electrochemical transducers can be mass-produced, the manufacturing cost of these devices is still too high for certain applications in which the sensor cannot be reutilised or recycled. Electrical readers are also expensive, and therefore their utilisation can only be justified in routine tests, for example in diagnostic tests r...

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Ultrasmall Quantum Dots with Broad‐Spectrum Metal Doping Ability for Trimodal Molecular Imaging

Tian

Shen

Zhou

et al. 2019

Adv Funct Materials

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Development of efficient targeting nanomaterials is extremely challenging due to the nonspecific accumulation in immune tissues, such as the liver and the spleen. Ultrasmall nanoparticles (USNPs) could possess small molecule-like in vivo pharmacokinetic profiles, coupled with integrated functions capacity, improving the molecular imaging efficiency, particularly in oncology. For nuclear imaging, radiometals are often incorporated into the structures of USNPs using chelator and chelator-free strategies. However, the incorporated chelator may change the surface properties and in vivo behavior of UNSPs, while chelator-free labeling strategies either involve complicated resynthesis or rely on the active properties of the metal ions. Herein, a novel chelator-free and postsynthetic strategy for broad-spectrum metal ion attachment is reported. The ultrasmall Ag 2 Se quantum dots (QDs) are developed with an active oxygen layer on the surface, allowing for facile incorporation of both active and inert metals with high labeling efficiency. The particles enable fluorescence, magnetic resonance imaging, and positron emission tomography (PET) trimodality imaging. After conjugation with targeting peptide, the probe yields a high tumor-to-muscle ratio of nine in PET imaging. Importantly, the QDs are predominantly excreted from body through the renal route within 12 h. This chelator-free strategy opens an avenue for exploring broad-spectrum radiometal isotope labeling and USNP-based renal-excreting imaging probes.

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Magnetically Engineered Semiconductor Quantum Dots as Multimodal Imaging Probes

Cited by 150 publications

References 314 publications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Solution-based nanosensors for in-field detection with the naked eye

Ultrasmall Quantum Dots with Broad‐Spectrum Metal Doping Ability for Trimodal Molecular Imaging

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