Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer

Abstract

The booming development of nanomedicine offers great opportunities for cancer diagnostics and therapeutics. Herein, a magnetic targeting-enhanced cancer theranostic strategy using a multifunctional magnetic-plasmonic nanoagent is developed, and a highly effective in vivo tumor photothermal therapy, which is carefully planed based on magnetic resonance (MR)/photoacoustic (PA) multimodal imaging, is realized. By applying an external magnetic fi eld (MF) focused on the targeted tumor, a magnetic targeting mediated enhanced permeability and retention (MT-EPR) effect is observed. While MR scanning provides tumor localization and reveals time-dependent tumor homing of nanoparticles for therapeutic planning, photoacoustic imaging with higher spatial resolution allows noninvasive fi ne tumor margin delineation and vivid visualization of three dimensional distributions of theranostic nanoparticles inside the tumor. Utilizing the near-infrared (NIR) plasmonic absorbance of those nanoparticles, selective photothermal tumor ablation, whose effi cacy is predicted by real-time infrared thermal imaging intra-therapeutically, is carried out and then monitored by MR imaging for post-treatment prognosis. Overall, this study illustrates the concept of imaging-guided MF-targeted photothermal therapy based on a multifunctional nano-agent, aiming at optimizing therapeutic planning to achieve the most effi cient cancer therapy.

Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy

“…The routine blood parameters of the treated group fell well in the normal range with no significant difference from those in controlled group (Table S1), suggesting the function of blood was not disrupted by the administration of the nanomaterial. These preliminary data demonstrated a satisfactory in vivo safety of the nanocapsules for biomedical applications, which was consistent with previously reported nanoagents consisting of gold and ferrite. , …”

“…As indicated in Figure , a considerable amount of nanocapsules was accumulated in tumors at 24 h postinjection, likely owing to the enhanced permeability and retention (EPR) effect. , Additionally, the nanocapsules were mainly distributed in liver and spleen, which were reticuloendothelial organs and responsible for the clearance of foreign nanoparticles . With the assistance of magnetic targeting, the amount of GNR@IOs-DOX in tumors was considerably enhanced (12.4% of injection dose compared with that of 5.6% from nontargeted tumors), which could be ascribed to the magnetic field promoted EPR effect . This efficient accumulation of the nanoagents at tumor site may facilitate the increase of local drug concentration as well as local photothermal heating for synergetic in vivo cancer therapy.…”

Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic‐Guided Chemotherapy

“…The standard treatment for NMIBC is a transurethral resection followed by an intravesical therapy . In these cases, the magnetic guiding of magnetic and drug‐containing nanoparticles can greatly enhance the delivery efficacy …”

Mesoporous Silica Coated Single‐Walled Carbon Nanotubes as a Multifunctional Light‐Responsive Platform for Cancer Combination Therapy

“…injection of SWNT@MS‐PEG/DOX into 4T1 tumor‐bearing mice, remarkably darken appearance was observed in the tumor region of mice from in vivo MR imaging, suggesting high tumor accumulation of those nanoparticles after systemic administration (Figure d). The quantitative MR imaging results based on region‐of‐interest (ROI) quantification further verify the T2 signals were obviously decreased in the tumor region after i.v. injection of SWNT@MS‐PEG for 24 hours (Figure e).…”