Magnetic resonance spectroscopy and gadolinium enhancement assist in the diagnosis of nonalcoholic Marchiafava-Bignami disease with necrosis lesions: a case description

Zhou, Zhiwei; Li, Qinghui; Pan, Cheng-Yu; Tao, Liang; Zhang, Tijiang; Xu, Ping

doi:10.21037/qims-21-632

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…The temporary dysfunction of axons can explain the partial recovery of NAA/Cr ratio, and the decrease of Cho/Cr ratio is synchronized with the chronic phase of demyelinating. Lac was initially replaced by lipid peak in chronic phase, which was consistent with axonal injury [30,35]. Lac or lipid peaks were not obvious after nearly 1 year of symptoms.…”

Section: Marchiafava-bignami Diseasementioning

confidence: 86%

Characteristics of Magnetic Resonance Spectroscopy in Toxic Leukoencephalopathy

Zhou¹,

Xu²

2024

Frontiers in Neuroimaging

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Toxic leukoencephalopathy (TLE) refers to a series of diseases with central nervous system damage caused by poisoning of various toxic substances, including medications, gases, drugs, and ethanol as the main clinical manifestation. TLE mainly causes the damage to white matter fibers and subcortical gray matter nuclei, including basal ganglia nuclei, thalamus and brainstem nuclei (substantia nigra red nucleus), as well as cerebellar dentate nucleus, which manifests as altered mental status, epilepsy, paresthesia, hemiparesis, tetraparesis, or even death. Magnetic resonance spectroscopy (MRS) has contributed to understanding the etiology and stage of TLE. Moreover, the change of brain metabolites, which can be evaluated by MRS, provides additional information for confirming diagnosis, monitoring disease progression, and informing treatment response. In order to describe the MRS characteristics of TLE caused by different etiologies, we will review the spectroscopy change of TLE which is associated with psychoactive substances, immunosuppressant, chemotherapy, and environment (PICE). Therefore, we reviewed the MRS characteristics of heroin-induced TLE, methadone-induced TLE, oxycodone-induced TLE, Wernicke encephalopathy, Marchiafava-Bignami disease, methotrexate-related TLE, metronidazole-induced TLE, carbon monoxide-related encephalopathy, and toluene TLE in this chapter.

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Section: Marchiafava-bignami Diseasementioning

confidence: 86%

Characteristics of Magnetic Resonance Spectroscopy in Toxic Leukoencephalopathy

Zhou¹,

Xu²

2024

Frontiers in Neuroimaging

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“…MBD is a rare demyelinating disease mainly related to alcohol abuse but also reported in the malnourished [2,3]. Although pathologic features of MBD are salient, the diagnosis of MBD is challenging because of the lack of specific symptoms or signs [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…Pathological characteristics of MBD include symmetrical demyelination, necrosis, and atrophy of the corpus callosum (CC). Extracallosal white matter can also be simultaneously affected, even the cortex [2]. Clinical manifestations of MBD lack specificity but generally include unconsciousness, confusion, delirium, mutism, seizures, and brain disconnection syndrome [3].…”

Section: Introductionmentioning

confidence: 99%

Marchiafava–Bignami disease after the white matter lesions: A case report

Zhou,

Chu,

et al. 2023

iRADIOLOGY

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Marchiafava–Bignami disease (MBD) is an uncommon alcoholism‐related neuropsychiatric disorder, featured with symmetrical demyelination of part or whole corpus callosum (CC). Previous studies reported follow‐up neuroimaging changes with necrosis, cystic degeneration, and atrophy of the CC after the diagnosis of MBD, but it is unclear whether the white matter is damaged before MBD. We report a case of alcoholic MBD whose magnetic resonance imaging revealed structural lesions in the white matter before the typical demyelination of CC during MBD, which support the prior hypothesis that chronic hazardous drinking may initially lead to microstructure abnormalities of the white matter and CC through some possible mechanisms, then microstructure lesions in the CC, and white matter deterioration into extensive demyelination, that is MBD. In future clinical practice, when patients with chronic alcoholism seek treatment for neuropsychiatric disorders, they may need to undergo repeated MRI scans to reveal progressive neuroimaging features before and after MBD.

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Magnetic resonance spectroscopy and gadolinium enhancement assist in the diagnosis of nonalcoholic Marchiafava-Bignami disease with necrosis lesions: a case description

Cited by 2 publications

References 18 publications

Characteristics of Magnetic Resonance Spectroscopy in Toxic Leukoencephalopathy

Characteristics of Magnetic Resonance Spectroscopy in Toxic Leukoencephalopathy

Marchiafava–Bignami disease after the white matter lesions: A case report

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