Magnetic Resonance Imaging of the Breast: Present and Future Roles

Harms, Steven E.; Flamig, Duane P.; Evans, W. Phil; Cheek, J. Harold; Peters, G.; Knox, Sally M.; Grant, Michael D.; Savino, Daniel A.; Jones, Stephen E.

doi:10.1080/08998280.1994.11929863

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…RODEO imaging can equally detect invasive carcinoma as well as ductal carcinoma in situ [24][25][26][27][28][29]. The remarkable ability of MR imaging to detect tumor margins and extent of disease indicates its potential for successful imaging control during ILP [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Mr Imagingmentioning

confidence: 99%

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Magnetic Resonance-Guided Interstitial Laser Photocoagulation for the Treatment of Breast Cancer

Harms¹

1999

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Section: Mr Imagingmentioning

confidence: 99%

“…The RODEO pulse sequence has accurately identified the cancers and margins in all cases [15][16][17][18][19][20][21][22][23][24][25].…”

Section: Mr Imagingmentioning

confidence: 99%

Magnetic Resonance-Guided Interstitial Laser Photocoagulation for the Treatment of Breast Cancer

Harms¹

1999

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“…MRI using rotating delivery of excitation off‐resonance (RODEO) of breast masses has recently been shown to more accurately diagnose and determine the extent of local breast cancer. Validation studies comparing RODEO breast MRI to serially sectioned mastectomy specimens have shown a high degree of correlation in the ability of this type of MRI to predict the extent of the disease (7–14). RODEO MRI has been used for more accurate measurement of the tumor in order to achieve a negative margin at the time of the lumpectomy (15–18).…”

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confidence: 99%

Assessment of Proliferating Cell Nuclear Antigen Activity Using Digital Image Analysis in Breast Carcinoma Following Magnetic Resonance-Guided Interstitial Laser Photocoagulation

Korourian¹,

Klimberg²,

Henry-Tillman³

et al. 2003

Breast Journal

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This study examines proliferative activity in tumor cells of patients with histologically documented invasive breast carcinoma treated with magnetic resonance-guided interstitial laser photocoagulation (MR-GILP). Immunohistochemical marker for proliferating cell nuclear antigen (PCNA), a nuclear protein abundant in actively proliferating cells, is used. The study demonstrates the effectiveness of MR-GILP in ablating tumor cells of infiltrating breast cancer. The diagnosis of infiltrating breast carcinoma was confirmed by core needle biopsies. Using a specially designed magnetic resonance imaging (MRI) device, rotating delivery of excitation off-resonance (RODEO), tumors were measured ranging from 1.8 to 4.0 cm in greatest dimension. Seven formalin-fixed, paraffin-embedded archival tissues from seven patients with infiltrating carcinoma, status post-MR-GILP, were analyzed. Using PCNA immunoperoxidase (Biomeda Corp.), the proliferative capability of the remaining tumor cells around the focus of laser photocoagulation was determined. The lesions were digitally acquired using a Nikon Eclipse E800 microscope with an automated stage. Images were analyzed using Cool SNAP image editing software (version 1.0). Appropriate thresholds were set for positive staining and limited concentric radial measurements of equal area between all samples were compared at radial millimeter intervals from the center of laser ablation. The integrated area occupied by PCNA-positive cells per radial millimeter from the charcoal site (the center of the laser) increased as the distance from this site increased (a mean average at each radial measurement revealed: at the 1 mm radius the positive integrated area was 0.0024 mm2; at 2 mm, 0.0145 mm2; at 3 mm, 0.0351 mm2; at 4 mm, 0.0696 mm2; at 5 mm, 0.1025 mm2; and at 6 mm, 0.1263 mm2). MR-GILP is an effective mean of ablating breast carcinoma. This treatment option may represent an alternative to lumpectomy for a single lesion < or =1 cm, or make patients with two separate lesions eligible for lumpectomy.

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Magnetic Resonance Imaging of the Breast: Present and Future Roles

Cited by 2 publications

References 18 publications

Magnetic Resonance-Guided Interstitial Laser Photocoagulation for the Treatment of Breast Cancer

Magnetic Resonance-Guided Interstitial Laser Photocoagulation for the Treatment of Breast Cancer

Assessment of Proliferating Cell Nuclear Antigen Activity Using Digital Image Analysis in Breast Carcinoma Following Magnetic Resonance-Guided Interstitial Laser Photocoagulation

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