Magnetic Resonance Imaging Findings in a Patient with Nuclear Oculomotor Palsy

Orengo-Nania, Silvia; Horowitz, Barry L.; Oram, Osman

doi:10.1097/00041327-199603000-00030

Cited by 2 publications

(3 citation statements)

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“…Oni se uglavnom odnose na dimenzije ispitivanih jedara i ćelija koje ih grade [3][4][5][6], dok se stereološki podaci ne nalaze. S druge strane, opisana su brojna oboljenja koja izazivaju promjene na ćelijama ekstraokularnih motornih jedara, što dovodi do odreĎenih kliničkih simptoma [15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Materijal I Metodeunclassified

Stereological analysis of neurons of extraocular motor nuclei

Sladojević¹,

Krivokuća²,

Bućma³

et al. 2009

Scripta Medica

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Sažetak. Neuroni ekstraokularnih motornih jedara (nucleus nervi oculomotorii principalis, nucleus nervi trochlearis et nucleus nervi abducentis) su zaobljeni multipolarni, rjeđe fuziformni ili ovalni motoneuroni, blijedog jedra i nepravilno raspoređenih Nisslovih tjelašaca. Cilj rada je da se odrede stereološki parametri neurona ekstraokularnih motornih jedara (volumenska i površinska gustina, i apsolutni broj po mm² površine). Istraživanje je obavljeno na 30 moždanih stabala čovjeka, oba pola, bez dijagnostikovanih neuroloških oboljenja, stratificiranim prikupljanjem uzoraka u transverzalnoj ravni. Semiserijski parafinski rezovi (debljine 0,3 µm) su bojeni Mallory metodom. Uz korišćenje mikroskopa na histološkim presjecima su identifikovana ekstraokularna motorna jedra i pomoću digitalne kamere slikano je intermitentno svako drugo vidno polje pod uvećanjem 400x. Dobijene slike su analizirane pomoću programa ImageJ, verzija 1.42e (National Institutes of Health, Bethesda, USA) uz korišćenje testnog sistema A 100. Statistička analiza je obavljena uz upotrebu programa SPSS (verzija 16.0) uz nivo značajnosti razlike od 5%. Statistički značajna razlika (p<0,05) postojala je u volumenskoj i površinskoj gustini, i apsolutnom broju neurona po mm² površine između nc.nervi oculomotorii principalis i nc.nervi trochlearis. Između nc.nervi oculomotorii principalis i nc.nervi abducentis statistički značajna razlika postoji u volumenskoj gustini, dok se između nc.nervi trochlearis i nc.nervi abducentis razlika pronalazi u vrijednosti površinske gustine i apsolutnog broja neurona po mm² površine.

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Section: Materijal I Metodeunclassified

Stereological analysis of neurons of extraocular motor nuclei

Sladojević¹,

Krivokuća²,

Bućma³

et al. 2009

Scripta Medica

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“…8,10,13,18,23,30,42,63,69,71,98,99,105 Bilateral ptosis is explained by damage of a single midline subnucleus at the caudal end of the oculomotor nucleus complex innervating both levator palpebrae superioris muscles. 8,10,12,42,63,69,71,99,105 Axons to the superior rectus muscle are crossed and pass through the superior rectus subnucleus of the other side. A lesion at that side would damage crossed axons from the contralateral superior rectus subnucleus, which project to the superior rectus muscle on the side of the lesion, and superior rectus motoneurons on the side of the lesion, which project to the contralateral rectus superior muscle.…”

Section: Anatomical Considerationsmentioning

confidence: 99%

“…A lesion at that side would damage crossed axons from the contralateral superior rectus subnucleus, which project to the superior rectus muscle on the side of the lesion, and superior rectus motoneurons on the side of the lesion, which project to the contralateral rectus superior muscle. 8,13,18,23,30,69,71,98,99,105 Clinical signs of an oculomotor palsy as the sole manifestation of MRI-documented oculomotor nucleus lesions are uncommon. 52,91,100 Lesions confined to the abducens nucleus produce a conjugate gaze paralysis to the side of the lesion.…”

Section: Anatomical Considerationsmentioning

confidence: 99%

Isolated cranial nerve palsies due to brainstem lesions

Thömke¹

1999

Muscle Nerve

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Isolated cranial nerve palsies are often attributed to lesions of the respective nerves along their extraaxial courses. There are a significant number of reports of individual patients with cranial nerve palsies, mostly of the 3rd and 6th nerves, as the sole manifestation of brainstem lesions proven by magnetic resonance imaging (MRI) or computer‐assisted tomography (CT). An intraaxial basis may still be underestimated if based on MRI only, as electrophysiological abnormalities indicating brainstem lesions (masseter reflex, blink reflex, DC electrooculography) may be independent from MRI‐documented morphological lesions. This article reviews the evidence that ischemic and demyelinating brainstem lesions are an important and underestimated cause of clinically isolated cranial nerve palsies. Especially in middle‐aged and elderly people with 3rd and 6th nerve palsies, small pontine and mesencephalic infarctions seem to be more frequent than small‐vessel ischemic infarctions of the extraaxial nerves. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1168–1176, 1999

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Magnetic Resonance Imaging Findings in a Patient with Nuclear Oculomotor Palsy

Cited by 2 publications

References 0 publications

Stereological analysis of neurons of extraocular motor nuclei

Stereological analysis of neurons of extraocular motor nuclei

Isolated cranial nerve palsies due to brainstem lesions

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