Magnetic resonance diffusion-weighted imaging in the characterization of pancreatic mucinous cystic lesions

Fatima, Zareen; Ichikawa, Tomoaki; Motosugi, Utarou; Muhi, Ali; Sano, Katsuhiro; Sou, Hironobu; Haradome, Hiroki; Kiryu, Shigeru; Araki, Tsutomu

doi:10.1016/j.crad.2010.10.004

Cited by 40 publications

(26 citation statements)

References 16 publications

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“…In another study, ADC value in intraductal papillary mucinous neoplasms (IPMNs) was significantly higher than in mucinous cystic neoplasms (MCNs) [20]. Although both IPMNs and MCNs contain mucinous cystic contents, IPMNs tend to have free flow due to cystic dilatation of the pancreatic duct and communication with the [20]. In our study, ADC value tended to be lower in the Breflux^kidney although it was not significant.…”

Section: Discussioncontrasting

confidence: 60%

“…Thus, measurement of ADC value can noninvasively assess salivary gland function [19]. In another study, ADC value in intraductal papillary mucinous neoplasms (IPMNs) was significantly higher than in mucinous cystic neoplasms (MCNs) [20]. Although both IPMNs and MCNs contain mucinous cystic contents, IPMNs tend to have free flow due to cystic dilatation of the pancreatic duct and communication with the [20].…”

Section: Discussionmentioning

confidence: 99%

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Intravoxel incoherent motion magnetic resonance imaging to predict vesicoureteral reflux in children with urinary tract infection

et al. 2015

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Intravoxel incoherent motion magnetic resonance imaging to predict vesicoureteral reflux in children with urinary tract infection

et al. 2015

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“…However, although serous cysts may lack visible internal complexity, they have micro-septations that may restrict the movement of water molecules inside the cyst. Moreover, as Fatima et al, previously hypothesized, IPMNs fluid may move more freely due to the presence of ductal communication, and may result in unexpectedly high ADC values (28). …”

Section: Discussionmentioning

confidence: 98%

“…DWI has been highly effective in identifying malignancy in solid lesions, but its role in pancreatic cysts is not well determined (21-29). Prior studies have evaluated the feasibility of DWI in pancreatic cystic lesions, with conflicting results (21-28). Some authors reported no differences between mucin-producing and serous cysts (21,22).…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere

Gutiérrez

Corona‐Villalobos

et al. 2016

Journal of Computer Assisted Tomography

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Objective To evaluate the feasibility and the reproducibility of diffusion-weighted imaging (DWI) in distinguishing between mucin-producing and serous pancreatic cysts. Methods Forty-four pancreatic cysts (43 patients; 27 females; mean age 57 years-old; 26 mucin-producing cysts; 18 serous cysts) underwent histological examination or cyst analysis after DW-MRI were retrospectively reviewed. Three blinded readers independently evaluated SI and ADC. Intra-observer and inter-observer agreements were calculated. Fisher's exact test and Welch's t test were used to compare SI and ADC values respectively, to pathological results. ROC analysis was used to determine diagnostic accuracy of various thresholds for ADC. A p value < 0.05 was considered statistically significant. Results Mean ADC value of the mucin-producing cysts was 3.26 ×10−3 mm2/sec, 3.27 ×10−3 mm2/sec and 3.35 ×10−3 mm2/sec for the three readers, respectively. Mean ADC value of the serous cysts was 2.86 ×10−3 mm2/sec, 2.85 ×10−3 mm2/sec and 2.85 ×10−3 mm2/sec for the three readers, respectively. Difference in ADC values between the two cyst groups was 12.4%, 12.9% and 14.8% for the three readers, respectively (p<0.001). Intra-observer and inter-observer agreement was excellent. A threshold ADC of 3×10−3 mm2/sec resulted in correct identification of cysts in 77-81% of cases, with sensitivity and specificity ranging between 84-88% and 66-72%, respectively. Conclusions DWI may be a helpful tool in distinguishing between mucin-producing and serous pancreatic cysts.

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“…DWI can provide qualitative and quantitative information reflecting changes at a cellular level and yields unique insights into tumor cellularity and the integrity of cell membranes (12). Recently, studies have suggested that quantitative measurement of the apparent diffusion coefficient (ADC) may have potential value for the characterization of cystic pancreatic lesions (13)(14)(15)(16). However, there is no consensus on the true value of ADC measurement appropriate for the evaluation of malignancy of IPMN.…”

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confidence: 99%

Value of apparent diffusion coefficient for predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas

Zhang

Rao²,

Xu³

et al. 2016

Diagn Interv Radiol

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Magnetic resonance diffusion-weighted imaging in the characterization of pancreatic mucinous cystic lesions

Cited by 40 publications

References 16 publications

Intravoxel incoherent motion magnetic resonance imaging to predict vesicoureteral reflux in children with urinary tract infection

Intravoxel incoherent motion magnetic resonance imaging to predict vesicoureteral reflux in children with urinary tract infection

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Value of apparent diffusion coefficient for predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas

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