Magnetic nanoparticle-linked colorimetric aptasensor for the detection of thrombin

Zhang, Zhanxia; Wang, Zhongjun; Wang, Xiaolei; Yang, Xiurong

doi:10.1016/j.snb.2010.02.013

Cited by 105 publications

(52 citation statements)

References 34 publications

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“…Many colorimetric biosensors employing enzyme mimics rely on the catalytic oxidation of peroxidase substrates, such as tetramethylbenzidine (TMB), in the presence of H 2 O 2 . Based on this process, colorimetric biosensors for trypsin, DNA, thrombin and glucose have been developed with enzyme mimics such as gold nanoclusters, carboxyl‐modified graphene oxide, Fe 3 O 4, CuS, and Co x Fe 3− x O 4 NPs. For example, Yan and co‐workers discovered that biologically and chemically inert Fe 3 O 4 magnetic NPs exhibit peroxidase‐like activity .…”

Section: Enzyme Mimics and Their Applicationsmentioning

confidence: 99%

Enzyme Mimics: Advances and Applications

Kuah

Toh

Yee

et al. 2016

Chemistry A European J

277

151

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Enzyme mimics or artificial enzymes are a class of catalysts that have been actively pursued for decades and have heralded much interest as potentially viable alternatives to natural enzymes. Aside from having catalytic activities similar to their natural counterparts, enzyme mimics have the desired advantages of tunable structures and catalytic efficiencies, excellent tolerance to experimental conditions, lower cost, and purely synthetic routes to their preparation. Although still in the midst of development, impressive advances have already been made. Enzyme mimics have shown immense potential in the catalysis of a wide range of chemical and biological reactions, the development of chemical and biological sensing and anti-biofouling systems, and the production of pharmaceuticals and clean fuels. This Review concerns the development of various types of enzyme mimics, namely polymeric and dendrimeric, supramolecular, nanoparticulate and proteinic enzyme mimics, with an emphasis on their synthesis, catalytic properties and technical applications. It provides an introduction to enzyme mimics and a comprehensive summary of the advances and current standings of their applications, and seeks to inspire researchers to perfect the design and synthesis of enzyme mimics and to tailor their functionality for a much wider range of applications.

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Section: Enzyme Mimics and Their Applicationsmentioning

confidence: 99%

Enzyme Mimics: Advances and Applications

Kuah

Toh

Yee

et al. 2016

Chemistry A European J

277

151

View full text Add to dashboard Cite

show abstract

“…Nanostructures, such as Fe 3 O 4 nanoparticles, sheet-like FeS nanostructure [12], single-wall carbon nanotubes [13], polymer coated CeO 2 nanoparticles [14], BiFeO 3 nanoparticles [15] and bimetallic alloy nanoparticles [16], were found to exhibit similar peroxidase or oxidase-like activity to that found in natural peroxidases and have been used as peroxidase mimics for the detection of H 2 O 2 [17], and thrombin [18]. Recently, Jv et al reported that positively charged gold nanoparticles ((+)AuNPs) possess intrinsic peroxidase mimicking activity and can catalyze the oxidation of a peroxidase substrate, 3,3,5,5-tetramethylbenzidine (TMB) by H 2 O 2 , which provides a simple and fast colorimetric method for the detection of H 2 O 2 [19].…”

Section: Introductionmentioning

confidence: 99%

Optimization of positively charged gold nanoparticles synthesized using a stainless-steel mesh and its application for colorimetric hydrogen peroxide detection

Han

Khan

Lee

2014

Journal of Industrial and Engineering Chemistry

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“…A novel colorimetric aptasensor for the detection of thrombin using chitosan-modified Fe 3 O 4 MNPs as a peroxidase mimic in the color reaction of H 2 O 2 /TMB solution was developed by Wang et al [105]. They demonstrated that the absorption values at 652 nm increased with the thrombin concentrations in a linear range of 1-100 nmol/L, and obtained a detection limit of 1 nmol/L thrombin.…”

Section: Magnetic Catalystmentioning

confidence: 99%