Magnetic lanthanum-doped hydroxyapatite/chitosan scaffolds with endogenous stem cell-recruiting and immunomodulatory properties for bone regeneration

Wang, Qiyang; Tang, Yaqi; Ke, Qinfei; Yin, Wenwu; Zhang, Changqing; Guo, Ya‐Jun; Guan, Junjie

doi:10.1039/d0tb00342e

Cited by 58 publications

(35 citation statements)

References 46 publications

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“…Hydroxyapatite, one form of calcium phosphate coating, has been widely used as a biocompatible scaffold for bioengineered bone implants (Wang et al, 2020;Yu et al, 2020;Zhu et al, 2020). However, it seems to have some certain type of acidity, whereas most reports have indicated that an alkaline environment inhibits the production of osteoclasts and promotes the proliferation of osteoblasts, thus reducing bone resorption (Arnett and Dempster, 1986;Arnett, 2008;Galow et al, 2017).…”

Section: Characterization and In Vitro Mineralization Of B-bgsmentioning

confidence: 99%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B2O3 (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO2. For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects.

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Section: Characterization and In Vitro Mineralization Of B-bgsmentioning

confidence: 99%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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“…[ 63 ] In addition, the incorporation of functional molecules or agents in scaffolds to modulate recruited macrophages has also drawn the interest of researchers. Biomolecules such as 25‐hydroxyvitamin D3, [ 64 ] SEW2871, [ 65 ] aspirin‐triggered resolvin D1, [ 66 ] polymerizable fucoidan and carrageenans, [ 67 ] lanthanum, [ 68 ] and sericin [ 69 ] capable of promoting M2 macrophage polarization or anti‐inflammatory processes were applied and investigated. Surface coatings for immune evasion have been widely investigated on synthetic material‐derived grafts as stealth coatings.…”

Section: Immunocompatibility Of Engineered Tissue or Organ‐based Implantsmentioning

confidence: 99%

Tissue Engineering for Mimics and Modulations of Immune Functions

Tao

Wang

2021

Adv Healthcare Materials

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In the field of regenerative medicine, advances in tissue engineering have surpassed the reconstruction of individual tissues or organs and begun to work towards engineering systemic factors such as immune objects and functions. The immune system plays a crucial role in protecting and regulating systemic functions in the human body. Engineered immune tissues and organs have shown potential in recovering dysfunctions and aplasia of the immune system and the evasion from immune‐mediated inflammatory responses and rejection elicited by engineered implants from allogeneic or xenogeneic sources are also being pursued to facilitate clinical transplantation of tissue engineered grafts. Here, current progress in tissue engineering to mimic or modulate immune functions is reviewed and elaborated from two perspectives: 1) engineering of immune tissues and organs per se and 2) immune evasion of host immunoinflammatory rejection by tissue‐engineered implants.

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“…In fact, the cytocompatibility and biodegradability of chitosan even when mixed with gold [72], silver [73] and iron oxide nanoparticles proposed this natural polymer as a suitable candidate for tissue engineering. CS is largely used in a mixture with several materials [74], including hydroxyapatite [75]. For example, it is possible to promote an in situ precipitation procedure to obtain very uniform and homogenous chitosan/hydroxyapatite and chitosan/hydroxyapatite/MNPs scaffolds using genipin with the double role of biocompatible material for improving the osteointegration and as a crosslinker agent [76].…”

Section: Mnps Enriched Scaffolds Without the Application Of An Externmentioning

confidence: 99%

“…In vivo tests, performed on bone defects induced in rabbit radius, showed that the bone regeneration process was accelerated with an increase in bone mineral density, percentage of bone volume/tissue volume ratio and new bone area formation in the presence of MNPs and an external magnetic field. The in vivo bioactivity of bone scaffold based on CS/n-HA was further increased using lanthanum doping [75], even though this biological mechanism is not still completely clear. In particular, SrFe12O9 M-type hexagonal ferrite was used to give magneto-responsive behavior to lanthanum doped CS/n-HA (MNPs-La-CS/n-HA) scaffolds.…”

Section: Mnps Enriched Scaffolds With the Application Of External Magmentioning

confidence: 99%

“…The live/dead cell staining evidenced a higher number of living BMSCs on MNPs-La-CS/n-HA than those ones observed on La-CS/n-HA and CS/n-HA. The influence of the effect of the magnetic nanoparticles and The in vivo bioactivity of bone scaffold based on CS/n-HA was further increased using lanthanum doping [75], even though this biological mechanism is not still completely clear. In particular, SrFe 12 O 9 M-type hexagonal ferrite was used to give magneto-responsive behavior to lanthanum doped CS/n-HA (MNPs-La-CS/n-HA) scaffolds.…”

Section: Mnps Enriched Scaffolds With the Application Of External Magmentioning

confidence: 99%

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Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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Magnetic lanthanum-doped hydroxyapatite/chitosan scaffolds with endogenous stem cell-recruiting and immunomodulatory properties for bone regeneration

Abstract: Magnetic lanthanum hydroxyapatite/chitosan scaffolds can better repair bone defects through stem cell recruitment and immunomodulation.

Cited by 58 publications

References 46 publications

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Tissue Engineering for Mimics and Modulations of Immune Functions

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

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