2004
DOI: 10.1007/s00280-004-0899-6 View full text |Buy / Rent full text
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Abstract: The Mg loss associated with cisplatin treatment was mainly the result of lowered intestinal absorption and not, as presently thought, the result of increased renal elimination. Instead, an increased renal reabsorption capacity was observed in response to decreased intestinal absorption. The study further showed that Mg and K metabolism are subject to predictable changes in intestinal absorption and renal excretion with each cisplatin treatment, and that knowledge of these changes can be used in planning supple… Show more

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“…16 In a study of K and Mg metabolism after repeated cisplatin treatments in rats it was found that cisplatin treatment exerted a negative effect on total K balance, although the difference between cisplatin-treated and control rats was not significant at the end of the follow-up. 3 Serum Mg levels showed an obvious and progressive decline in our patients. This finding is supported by similar reports in the literature.…”
Section: Discussionmentioning
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“…16 In a study of K and Mg metabolism after repeated cisplatin treatments in rats it was found that cisplatin treatment exerted a negative effect on total K balance, although the difference between cisplatin-treated and control rats was not significant at the end of the follow-up. 3 Serum Mg levels showed an obvious and progressive decline in our patients. This finding is supported by similar reports in the literature.…”
Section: Discussionmentioning
“…Lajer et al investigated changes in renal and intestinal homeostasis of Mg and K during repeated cisplatin treatments in rats. 3 Cisplatin exerted a significant negative effect on total Mg balance. This effect was cumulative.…”
Section: Discussionmentioning
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“…2 It is known to cause urinary magnesium wasting leading to hypomagnesemia and hypocalcemia. 3 Spironolactone, an antagonist of the adrenal mineralocorticoid (aldosterone), is known to have hypotensive properties and has been used in the treatment of congestive heart failure. 4 In primary hyperaldosteronism it rapidly corrects the biochemical abnormalities and usually restores the blood pressure to normal.…”
Section: Introductionmentioning