Macular Structures, Optical Components, and Visual Acuity in Preschool Children after Intravitreal Bevacizumab or Laser Treatment

Lee, Yung-Sung; See, Lai‐Chu; Chang, Shu‐Hao; Wang, Nan-Kai; Hwang, Yih-Shiou; Lai, Chi-Chun; Chen, Kuan‐Jen; Wu, Wei‐Chi

doi:10.1016/j.ajo.2018.05.002

Cited by 47 publications

(43 citation statements)

References 36 publications

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“…We observed that eyes with LP exhibited smaller FAZ and greater CFT than that with IVR ( table 1 , figure 2 ), which is consistent with the previous study. 16 Vogel et al 4 reported that LP was associated with extrusion of the inner retinal layers. The LP leads to the destruction of the avascular retina which prevents the peripheral migration and reorganisation of inner retinal cells, whereas the inner retinal cells in the IVR-treated eyes continue to migrate.…”

Section: Discussionmentioning

confidence: 99%

“…The LP leads to the destruction of the avascular retina which prevents the peripheral migration and reorganisation of inner retinal cells, whereas the inner retinal cells in the IVR-treated eyes continue to migrate. 16 This implies that LP contributes to the smaller FAZ area and thicker CFT.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the central foveal area is defined as the small circle (red zone) with 1 mm in diameter and centred at the fovea; the foveal area is defined as the large circle with 3 mm in diameter and centred at the fovea; the parafoveal area is defined as the annular area (green zone) in which the large circle without the small central circle ( figure 1 ). 16 The total parameters using OCTA mode were as follows: central foveal VLD and PD, parafoveal VLD and PD, foveal the VLD and PD, FAZ area, as well as FAZ MI. The CFT was measured using cross-sectional OCT. All children’s visual acuity and refraction data were recorded.…”

Section: Methodsmentioning

confidence: 99%

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Comparison of OCT angiography in children with a history of intravitreal injection of ranibizumab versus laser photocoagulation for retinopathy of prematurity

Zhao

Lam

et al. 2020

Br J Ophthalmol

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PurposeTo compare the foveal microvascular structure characteristics in children with a history of intravitreal injection of ranibizumab (IVR) versus laser photocoagulation (LP) for retinopathy of prematurity by optical coherence tomography angiography (OCTA).MethodsIn this cross-sectional study, a total of 17 children (28 eyes) underwent IVR and 20 children (37 eyes) underwent LP were recruited. The age of doing OCTA examination of the two groups are 5.4±1.1 years and 6.3±1.8 years, respectively (p=0.07). Spectral-domain OCTA was performed for all the eyes with a scan size of 3×3 mm. The data of the superficial retinal layer were analysed. The foveal avascular zone (FAZ) and vessel density (including vessel length density (VLD) and perfusion density (PD)) were measured using the software of OCTA (Cirrus AngioPlex 5000, Carl Zeiss, Meditec, Dubin, California, USA). The central foveal thicknesses (CFT) were measured by cross-sectional OCT.ResultsIn the central fovea, the retinal VLD and PD of patients with IVR were 13.82±2.99 mm/mm2 and 0.25±0.05 mm2/mm2, respectively, which were significantly lower than those of the LP group (15.64±2.71 mm/mm2 and 0.28±0.05 mm2/mm2, p=0.01 and p=0.006). The FAZ area of patients with IVR and LP were 0.13±0.09 mm2 and 0.09±0.07 mm2, respectively (p=0.048). The CFT of patients with IVR and LP were 200.7±16.7 µm and 220.9±22.7 µm, respectively (p<0.01). The logarithm of the minimal angle of resolution best-corrected visual acuity of patients with IVR and LP were 0.2±0.1 and 0.1±0.1, respectively (p=0.01). There was no significant difference in the parafoveal and foveal VLD and PD, FAZ morphological index and spherical equivalent refraction (SER) between the two groups.ConclusionThe IVR might contribute to microvascular changes in the macular zone, such as reducing the central foveal VLD and PD, while the LP might contribute to microstructural changes, such as smaller FAZ and thicker CFT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of OCT angiography in children with a history of intravitreal injection of ranibizumab versus laser photocoagulation for retinopathy of prematurity

Zhao

Lam

et al. 2020

Br J Ophthalmol

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“…Twenty-three relevant studies were included for a qualitative synthesis by table and plot. Two RCTs (Geloneck 2014 [44]; O'Keeffe 2016 [45]) and 5 NRSs (Harder 2013 [8]; Gunay 2015 [22]; Hwang 2015 [10]; Isaac 2015 [11]; Lee 2018 [46]), including a total of 272 eyes treated by IVB and 247 eyes treated by laser, were ultimately included for a quantitative synthesis by meta-analysis. Two of 7 studies implemented comparisons in Zone I and Zone II ROP classifications [10, 44].…”

Section: Resultsmentioning

confidence: 99%

“…From the 7 studies, data of astigmatism from 3 NRSs (Harder 2013 [8]; Hwang 2015 [10]; Lee 2018 [46]) were available for Meta-analysis. A total of 76 eyes treated by IVB and 79 eyes treated by laser were included.…”

Section: Resultsmentioning

confidence: 99%

Development of refractive error in children treated for retinopathy of prematurity with anti-vascular endothelial growth factor (anti-VEGF) agents: A meta-analysis and systematic review

2019

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ObjectiveTo investigate refractive error development in preterm children with severe retinopathy of prematurity (ROP) treated with anti-vascular endothelial growth factor (anti-VEGF) agents and laser photocoagulation.MethodsSelection criteria were comparative studies that compared the refractive errors in children, birthweights ≤1500 grams and gestational ages ≤30 weeks, and treatments for Type I ROP with intravitreal bevacizumab (IVB) versus laser photocoagulation. Studies were identified using PubMed, Google Scholar, and published reviews. Meta-analyses were performed on the post-treatment outcomes of spherical equivalent (SEQ), cylindrical power, and prevalence of high myopia. Longitudinal development of refractive error in IVB, or in laser-treated children, or in normal full-term children was visually summarized.ResultsTwo randomized controlled trials and 5 non-randomized studies, including a total of 272 eyes treated by IVB and 247 eyes treated by laser, were included in this study. Compared with laser-treated children, IVB-treated children have less myopic refractive error (P<0.001), lower prevalence of high myopia (P<0.05), and less astigmatism (P = 0.02).ConclusionsTreatment with IVB is associated with less myopia and astigmatism than laser treatment for infants with severe ROP. Given the complexity of ROP and the variability of dosing, our review supports close monitoring of refractive error outcomes in children treated with IVB.

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Epidemiologie und Anatomie der Myopie

Jonas

Panda‐Jonas²

2019

Ophthalmologe

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Macular Structures, Optical Components, and Visual Acuity in Preschool Children after Intravitreal Bevacizumab or Laser Treatment

Cited by 47 publications

References 36 publications

Comparison of OCT angiography in children with a history of intravitreal injection of ranibizumab versus laser photocoagulation for retinopathy of prematurity

Comparison of OCT angiography in children with a history of intravitreal injection of ranibizumab versus laser photocoagulation for retinopathy of prematurity

Development of refractive error in children treated for retinopathy of prematurity with anti-vascular endothelial growth factor (anti-VEGF) agents: A meta-analysis and systematic review

Epidemiologie und Anatomie der Myopie

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