Macroporous Adhesive Nano‐Enabled Hydrogels Generated from Air‐in‐Water Emulsions

Xie, Manshan; Zheng, Zhiwen; Pu, Shiheng; Jia, Yong‐Guang; Wang, Lin; Chen, Yunhua

doi:10.1002/mabi.202100491

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…However, the physical hemostatic barrier form by hydrogel‐based powder is usually weak and cannot achieve effective hemostatic in major bleeding. Sponge [ 6,52,60 ] and aerogel [ 83,103 ] are the other two varieties of adhesive hemostatic hydrogels (Figure 7f). The hemostasis of acute or major bleeding wounds can be achieved by enriching coagulation factors and platelets.…”

Section: Commonly Used Forms and Hemostatic Evaluation Models Of The ...mentioning

confidence: 99%

Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface

Zhang

Shi

Xiao

et al. 2022

Advanced NanoBiomed Research

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Adhesive hemostatic hydrogels, as one of the most important wound dressings, have attracted tremendous attention because of their unique advantages in injured tissue. Many intensive efforts are devoted to designing ingenious adhesive hemostatic hydrogels based on interfacial interactions with tissue surfaces, such as covalent bonds, hydrogen bonds, electrostatic interactions, cation–π interactions, and π–π stacking interactions. Herein, an overview of the recent progress in adhesive hemostatic hydrogels is provided, especially focusing on diverse covalent/noncovalent interfacial interactions between the active groups of adhesive hydrogels and tissue surface. The commonly used forms and the hemostatic evaluation models of the adhesive hydrogels are also summarized. Finally, the critical issues that should be concerned for current adhesive hemostatic hydrogels and the developing directions toward practical applications are discussed.

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Section: Commonly Used Forms and Hemostatic Evaluation Models Of The ...mentioning

confidence: 99%

Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface

Zhang

Shi

Xiao

et al. 2022

Advanced NanoBiomed Research

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“…Fourth, their relatively weak mechanical properties. The introduction of macropores generally reduces the total solids content of the hydrogel, and its stiffness and fatigue resistance further decrease with increasing pore size [ 29 , 30 ]. Fifth, tissue-like biomimetic structures and physical hierarchies in tissues are important for the regulation of cell behavior.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Wang

et al. 2022

Gels

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Hydrogels have been extensively used as scaffolds in tissue engineering for cell adhesion, proliferation, migration, and differentiation because of their high-water content and biocompatibility similarity to the extracellular matrix. However, submicron or nanosized pore networks within hydrogels severely limit cell survival and tissue regeneration. In recent years, the application of macroporous hydrogels in tissue engineering has received considerable attention. The macroporous structure not only facilitates nutrient transportation and metabolite discharge but also provides more space for cell behavior and tissue formation. Several strategies for creating and functionalizing macroporous hydrogels have been reported. This review began with an overview of the advantages and challenges of macroporous hydrogels in the regulation of cellular behavior. In addition, advanced methods for the preparation of macroporous hydrogels to modulate cellular behavior were discussed. Finally, future research in related fields was discussed.

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“… 8 Therefore, nanoclay is often used to cross-link various polymers, such as polydopamine (PDA), and interact with them to form hydrogels with a double network structure, improving physical and mechanical properties. 12 PDA is a black-brown coating produced by the aerobic weak base environment of dopamine with extremely strong adhesion properties and various active functional groups. 13 , 14 Among them, the highly transitive catechol and amine functional groups on the PDA chains not only enhance the interfacial interactions between the clay nanosheets and the polymer network through physical cross-linking but also achieve functional coating loading by non-covalent and covalent chemical reactions with the substrate.…”

Section: Introductionmentioning

confidence: 99%

Multidynamic Osteogenic Differentiation by Effective Polydopamine Micro-Arc Oxide Manipulations

Zhou¹,

Wang²,

Wang³

et al. 2022

IJN

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Introduction The nanostructural modification of the oral implant surface can effectively mimic the morphology of natural bone tissue, allowing osteoblasts to achieve both proliferation and differentiation capabilities at the bone interface of the dental implant. To improve the osteoinductive activity on the surface of titanium implants for rapid osseointegration, we prepared a novel composite coating (MAO-PDA-NC) by micro-arc oxidation technique and immersion method and evaluated the proliferation, adhesion, and osteogenic differentiation of osteoblasts on this coating. Methods The coatings were prepared by micro-arc oxidation (MAO) technique and immersion method, and characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) for different coatings; the loading of PDA was examined using Fourier transform infrared spectroscopy (FTIR); the ion release capacity of the coatings was determined by inductively coupled plasma emission spectrometry (ICP-OES); the interfacial bonding of the coatings was examined using nanoscratch experiment strength. The cytotoxicity of the coating was examined by live/dead staining kit; cell proliferation viability was examined by CCK-8 kit; adhesion and osteogenic effect of the coating were examined by immunofluorescence staining and RT-PCR; osteogenic differentiation was examined by alkaline phosphatase staining. Results The surface morphology of titanium implants was modified by micro-arc oxidation technology, and a new MAO-PDA-NC composite coating was successfully prepared. The results showed that the MAO-PDA-NC coating not only optimized the physical and chemical properties of the titanium implant surface but also significantly stimulated the biological properties of osteoblast adhesion, proliferation, and osteogenic differentiation on the coating surface. Conclusion These results show that MAO-PDA-NC composite coating can significantly improve the surface properties of titanium implants and achieve a stable bond between implant and bone tissue, thus accelerating early osseointegration.

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Macroporous Adhesive Nano‐Enabled Hydrogels Generated from Air‐in‐Water Emulsions

Cited by 11 publications

References 35 publications

Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface

Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface

Recent Advances in Macroporous Hydrogels for Cell Behavior and Tissue Engineering

Multidynamic Osteogenic Differentiation by Effective Polydopamine Micro-Arc Oxide Manipulations

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