Macrophages undergo a behavioural switch during wound healing in zebrafish

Protectins: Their biosynthesis, metabolism and structure-functions

“…Elucidating the biosynthetic pathways and receptor effects are important in order to understand and appreciate the bioactivities of the protectins, but are also highly relevant for the resolution pharmacology field [73]. Today this an attractive and rapidly maturing field of biomedical research, exemplified by recent findings [74,75,76]. For example, Nguyen-Chi and co-workers discovered that during wound healing in Zebra fish, PD1 mediated a macrophage phenotype switch to the M2 phenotype that is required for wound healing [74].…”

“…Today this an attractive and rapidly maturing field of biomedical research, exemplified by recent findings [74,75,76]. For example, Nguyen-Chi and co-workers discovered that during wound healing in Zebra fish, PD1 mediated a macrophage phenotype switch to the M2 phenotype that is required for wound healing [74]. This process was governed by 15-LOX, the key enzyme in the biosynthesis of PD1 [74].…”

“…For example, Nguyen-Chi and co-workers discovered that during wound healing in Zebra fish, PD1 mediated a macrophage phenotype switch to the M2 phenotype that is required for wound healing [74]. This process was governed by 15-LOX, the key enzyme in the biosynthesis of PD1 [74]. Earlier Yao and co-workers reported that PDX increased the survival rates of mice suffering sepsis and that the percentage of M2 macrophages in peritoneum of septic mice was elevated [75].…”

Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators

“…Enhanced post-surgical general and memory functions by inhibiting activation of the microglia and astrocytes. Promoted activation of M2 macrophages signifying NPD1 anti-inflammatory, and pro-resolving effects [237] ,also this phenotypic switch which was essential for wound healing, was accelerated by PD1 as seen in zebra fish model [238] . NPD1/PD1 leads to neural plasticity via regulation of TRPV1/TNF-α- pathway also helps in reducing pain via TRPV1 modulation [239] .…”

Multiple Shades of Gray—Macrophages in Acute Allograft Rejection

“…Due to their highly plastic properties, macrophages can assist in all steps of inflammation starting from the initial inflammatory mounting phase and ranging to the resolution phase where tissue regeneration and repair is finalized [60]. In a zebrafish fin amputation model, it could be shown that macrophages were attracted to the wound in a single wave and changed their shape and behavior depending on the requirements directly at the wounded site [61]. The same study also provided a link to lipid metabolism, by showing the implication of polyunsaturated fatty acid (PUFA) metabolism and 15-lipoxygenase on the morphology and polarization of macrophages.…”