Macrophages as Effectors of Cell-Mediated Immunity

Nelson, David S.; Solotorovsky, Morris

doi:10.3109/10408417209103871

Cited by 49 publications

(25 citation statements)

References 234 publications

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“…The protection against lethal injection which is nortnally induced by transfer of lymphoid cells from immunised donors to immunised recipients can he abolished if the recipients are irradiated prior to cell trati.sfer (Tripath) or are given a course of \-inblastin (North, 1970) or cyclophosphamide (McGregor and Ko.ster, 1971), treatments known to interfere with the production of monocytes. Similar experiments l)v a number of other workers ha\{' supported the idea that the process of macrophage activation plays an important role in the defenc-e against tnany pathogens (Nelson, 1972;Anderson and Remington, 1974).…”

Section: Introductionsupporting

confidence: 63%

The Role of Thymus‐derived Cells in Immunity to Salmonella Infection

Davies

Kotlarski

1976

Aust J Exp Biol Med

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Summary The ability of thymus‐derived (T) cell depleted mice to eliminate a dose of the normally avirulent 11RX strain of Salmonella enteritidis was compared to that of normal mice by following the fate of the challenge organisms in the liver and spleen of both types of mice. Although the mice did not require normal numbers of T cells to survive infection with Salmonella enteritidis 11RX, T cell depiction reduced the ability of mice effectively to eliminate the organism from their tissues. In addition, T cell depletion abolished the ability of live Salmonella enteritidis 11RX vaccine to protect mice against a subsequent challenge with the virulent C5 strain of Salmonella typhimurium.

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Section: Introductionsupporting

confidence: 63%

The Role of Thymus‐derived Cells in Immunity to Salmonella Infection

Davies

Kotlarski

1976

Aust J Exp Biol Med

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“…This situation is, however, clearly different from that which we have studied and there is no real conflict of data or interpretation. There is evidence that acquired cellular resistance to certain infections depends more upon the activation of monocytes newly produced, in increasing numbers, in the bone marrow than upon proliferation of mature macrophages [26,38], The ability of locally resident macrophages to proliferate may, however, provide a useful reserve or amplifying mechanism [9,22], Changes were also noted in lymphocyte counts in the peritoneal cavi ties and blood of challenged mice, both normal and immunized. In the peritoneal cavities of immunized mice there was a fall in the total lym phocyte count from 24 to 72 h, and a transient rise in blood lymphocyte counts at 4 h. In normal mice there was a fall in the peritoneal lympho cyte counts from 24 to 96 h while the blood lymphocyte counts showed a transient fall at 24 h followed by a rise from 48 to 96 h. Little or nothing is known of the kinetics of lymphocytes in the unstimulated peritoneal cavity.…”

Section: Discussionmentioning

confidence: 97%

“…Proliferation of cells of the mononuclear phagocytic system is a fea ture of a variety of inflammatory reactions, especially those associated with cell-mediated immunity (CMI) [22,37]. The proliferation can in volve monocyte precursors in the bone marrow [36,38] macrophages which have recently entered lesions [1] and mature resident macrophages, e.g.…”

Section: Introductionmentioning

confidence: 99%

Further Observations on the Immunological Induction of DNA Synthesis in Mouse Peritoneal Macrophages

Izumi¹,

Penrose²,

More³

et al. 1975

Int Arch Allergy Immunol

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Subcutaneous injection of ovalbumin (OA) into mice immunized with OA in Freund’s complete adjuvant was followed by an increase in the numbers of peritoneal macrophages synthesizing DNA, determined by autoradiography. The effect was immunologically specific. The increase was followed by an increase in the numbers of peritoneal macrophages; the numbers of peritoneal lymphocytes also increased. Injection of OA into immunized or normal mice was followed by a blood monocytosis. Increased DNA synthesis, determined by liquid scintillation counting, occurred in spleen or lymph node cells from immunized mice, cultured with OA. Diluted supernatants from such cultures, injected intravenously into normal mice, caused increases in the numbers of DNA-synthesizing peritoneal macrophages. Similarly, supernatants from concanavalin A stimulated spleen cells, freed of Con A, also caused an increase in DNA-synthesizing macrophages.

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“…As macrophages activated in various ways have anti-tumour activity (Hibbs, 1973;Keller, 1973; Alexander, 1972, 1976) it should not be surprising if the converse were true and tumour immunity were accompanied by macrophage activation. A DNA synthetic response of macrophages in the unstimulated peritoneal cavity has been found to accompany cell-mediated immune reactions (More et al, 1973) though it is not an inevitable accompaniment of activation, in the sense of intracellular microbicidal activity (North, 1970;Nelson, 1972). It remains to be determined whether tumour growth brings about activation in this strict sense.…”

Section: Discussionmentioning

confidence: 99%

Macrophages and lymphoid tissues in mice with concomitant tumour immunity

Nelson¹,

Kearney²

1976

Br J Cancer

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Summary.-The growth in mice of subcutaneous isografts of any of 5 methylcholanthrene-induced fibrosarcomas was associated with macrophage stimulation, reflected in an increased incidence of DNA-synthesizing cells among macrophages in the uninjected peritoneal cavity. This occurred at some stage with 4 tumours that induced concomitant immunity and one that did not. Some degree of splenomegaly also occurred with all 5 tumours. The spleens of all the tumour-bearing mice showed histological evidence of increased haemopoietic activity. Histological changes in the lymphoid elements of the spleen were very different with different tumours, ranging from lymphoid stimulation to lymphoid atrophy. The lymph nodes draining the sites of primary isografts which induced concomitant immunity showed signs of stimulation in the paracortical areas, followed by plasmacytopoiesis in the medullary areas. Stimulation of the paracortical areas was not detected in the nodes draining sites of injection of a tumour not inducing concomitant immunity. Nodes draining the sites of challenge isografts in mice exhibiting concomitant immunity showed plasmacytopoiesis.

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Macrophages as Effectors of Cell-Mediated Immunity

Cited by 49 publications

References 234 publications

The Role of Thymus‐derived Cells in Immunity to Salmonella Infection

The Role of Thymus‐derived Cells in Immunity to Salmonella Infection

Further Observations on the Immunological Induction of DNA Synthesis in Mouse Peritoneal Macrophages

Macrophages and lymphoid tissues in mice with concomitant tumour immunity

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