Macrophage-related diseases of the gut: a pathologist's perspective

Tousseyn, Thomas; Hertogh, Gert De; Geboes, Karel

doi:10.1007/s00428-012-1244-9

Cited by 28 publications

(30 citation statements)

References 103 publications

(88 reference statements)

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“…In the histopathology of small intestinal biopsy specimens, other possible causes of PAS-positive staining of macrophages must be considered (e.g., Mycobacterium avium infection, systemic histoplasmosis, or macroglobulinemia) [52]. This might be difficult in some cases even in endoscopy as Mycobacterium avium infection might also mimic the enteroscopic pattern of Whipple's disease [53, 54].…”

Section: Differential Diagnosismentioning

confidence: 99%

Whipple’s Disease: Our Own Experience and Review of the Literature

Bureš

Kopáčová

Douda

et al. 2013

Gastroenterology Research and Practice

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Whipple's disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei. Nondeforming arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever. Possible neurologic symptoms (up to 20%) might be associated with worse prognosis. Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material. Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases. This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre. Patients were treated using i.v. penicillin G or amoxicillin-clavulanic acid + i.v. gentamicin for two weeks, followed by p.o. doxycycline (100 mg per day) plus p.o. salazopyrine (3 g per day) for 1 year. Full remission was achieved in all our patients.

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Section: Differential Diagnosismentioning

confidence: 99%

Whipple’s Disease: Our Own Experience and Review of the Literature

Bureš

Kopáčová

Douda

et al. 2013

Gastroenterology Research and Practice

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“…Macrophages are important residents in all tissues and are central mediators of the immune system that contribute to the initiation and resolution of inflammation and that regulate tissue homeostasis; additionally, macrophages are critically involved in diseases that are caused by chronic inflammation (e.g., arthritis, multiple sclerosis, diabetic ulcers, inflammatory bowel diseases, cardiovascular disease) [9], [10], [11], [12], [13]. In solid tumors, macrophages are also major determinants of immune suppression [9].…”

Section: Introductionmentioning

confidence: 99%

Apigenin Induces the Apoptosis and Regulates MAPK Signaling Pathways in Mouse Macrophage ANA-1 Cells

et al. 2014

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Apigenin is a naturally occurring plant flavonoid that possesses antioxidant, anti-cancer and anti-inflammatory properties. However, there are few reports has been done on the ability of apigenin to induce apoptosis in macrophages. In this study, mouse macrophage ANA-1 cells were incubated with different concentrations of apigenin. The cell viability was determined by an MTT assay. The cell apoptosis were analyzed by flow cytometric analysis. Apoptosis were also analyzed using a TUNEL assay and a DNA ladder. The level of intracellular ROS was detected using a dichlorofluorescein -diacetate probe. The expression levels of apoptosis-related proteins were detected by western blot analysis. The results showed that apigenin decreased the viability of ANA-1 cells and induced apoptosis in a dose- and time-dependent manner. Apigenin increased the level of intracellular ROS, downregulated the expression of Bcl-2 and upregulated the expression of caspase-3 and caspase-8 in ANA-1 cells. Furthermore, apigenin downregulated the expression of phospho-ERK and phospho-JNK, upregulated the expression of phospho-p38 and had no significant effect on the expression of Bax, ERK, JNK and p38. The results suggested that apigenin induced cell apoptosis in mouse macrophage ANA-1 cells may via increasing intracellular ROS, regulating the MAPK pathway, and then inhibiting Bcl-2 expression.

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“…The enlarged macrophages containing small vacuoles, or foamy macrophages seen in the present material, likely represent activated macrophages. Such macrophages may contain various types of materials (Sagaert, Tousseyn, De Hertogh, & Geboes, ). In this study, the presence, in foamy macrophages, of acidic and neutral mucins may imply that foamy macrophages engulfed mucins.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous enteritis in rainbow trout (Oncorhynchus mykiss) associated with soya bean meal regardless of water dissolved oxygen level

Mosberian-Tanha

Landsverk

Press

et al. 2017

Journal of Fish Diseases

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This study investigated morphological changes associated with soya bean meal-induced enteritis (SBMIE) in distal intestine (DI) of rainbow trout (Oncorhynchus mykiss) fed a soya bean meal (SBM)-based diet and exposed to normoxia or hypoxia created by optimal and low water flow rates, respectively. A 28-day adaption period was followed by a 42-day challenge period where 600 fish were subjected to dietary challenge and/or hypoxia. Twelve tanks each containing 50 juvenile trout were assigned randomly in triplicate to each treatment. Histopathological and immunohistochemical evaluation revealed pathological features that have not previously been described in association with SBMIE. Vacuolar degeneration of epithelial cells mainly at the base of mucosal folds, epithelial cysts, epithelial dysplasia, necrosis, shedding of necrotic cells, and granulomatous inflammation including infiltration of enlarged, sometimes finely vacuolated or "foamy" macrophages, multinucleated giant cells and increased proliferation of fibroblasts were observed. Acid-fast bacteria were not detected in enlarged macrophages; however, these cells contained AB-PAS- and sometimes cytokeratin-positive material, which was interpreted to be of epithelial/goblet cell origin. Hypoxia did not affect the morphological changes in DI. These results suggest that SBM was associated with a granulomatous form of enteritis in DI of rainbow trout regardless of water oxygen level.

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Macrophage-related diseases of the gut: a pathologist's perspective

Cited by 28 publications

References 103 publications

Whipple’s Disease: Our Own Experience and Review of the Literature

Whipple’s Disease: Our Own Experience and Review of the Literature

Apigenin Induces the Apoptosis and Regulates MAPK Signaling Pathways in Mouse Macrophage ANA-1 Cells

Granulomatous enteritis in rainbow trout (Oncorhynchus mykiss) associated with soya bean meal regardless of water dissolved oxygen level

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