Current Opinion in Lipidology volume 25, issue 5, P367-373 2014 DOI: 10.1097/mol.0000000000000109 View full text
Jan Van den Bossche, Annette E. Neele, Marten A. Hoeksema, Menno P.J. de Winther

Abstract: We recap epigenetic features of distinct enhancers and describe the role of Jumonji domain-containing protein 3 (Jmjd3) and Hdac3 as crucial mediators of macrophage differentiation, activation and polarization. We hypothesize that epigenetic enzymes could serve as the link between environment, cellular metabolism and macrophage phenotype. To conclude, we propose epigenetic intervention as a future pharmacological target to modulate macrophage polarization and to treat inflammatory diseases such as atherosclero…

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